Dahili Tıp Bilimleri Bölümü Makale Koleksiyonu

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https://hdl.handle.net/20.500.12418/282

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Zihinsel Engelliliği Olan Ergenlerde Cinsel Davranışların Değerlendirilmesi
(Gaziosmanpaşa Üniversitesi Tıp Fakültesi Dergisi, 2022) Nemnezi Karaca, Sanem; Uzun Çiçek, Ayla
Objectives: Adolescents with intellectual disability (ID) are more likely than the general population to exhibit inappropriate and unsafe sexual behaviors and sexual behavior problems. However, few studies have investigated sexual behavior problems in these adolescents. Thus, the present study aimed to examine the types, frequency, and associated clinical features of inappropriate sexual behaviors in adolescents with ID. Material and Methods: This study included 74 adolescents diagnosed with ZE between the ages of 12-18, registered in the child and adolescent psychiatry outpatient clinic. A questionnaire form via Google documents was shared with the parents through the access networks that they could reach by contacting the parents, and the parents were asked to fill it out in order to obtain sociodemographic data and sexual behavior characteristics of the participants. Results: In our sample, the prevalence of sexual behavior problems was 35.1% and the rate of inappropriate sexual behavior in the community was 27%. Masturbation was the most commonly observed sexual behavior. Sexual behavior problems did not differ according to age and gender. However, the ID degree was significantly more severe in the group with sexual behavior problems. The rate of parents giving sexual education to their children was 18.9%, and the rate of having received sexual education by any professional for sexual behavior problems was 8.1%. Conclusion: Our results support the finding that adolescents with ID have a high risk of experiencing sexual behavior problems. In addition, it is clearly seen that there is a need for comprehensive sexual education and intervention for adolescents with ID and their families. Clinicians, psychologists, and teachers should all be aware of this.
Epidemiology and Nature of Suicide Attempts in Children and Adolescents at the Tertiary Care Pediatric Hospitals; a Multicentre Retrospective Study in Turkey
(Journal of Critical and Intensive Care, 2022) Saraç Sandal, Özlem; Ongun, Ebru Atike; Uzun Çiçek, Ayla; Sarı, Seda Aybüke; Temel, Özlem; Ceylan, Gökhan
Introduction: Suicide and suicide attempts are among the leading causes of morbidity and mortality in the youth population worldwide, with drastically increased rates over the past years. Objectives: We aimed to investigate the major risk factors, sociodemographic characteristics, and prevalence of psychiatric comorbidities in children that hospitalized in pediatric intensive care units (PICUs) for selfpoisoning suicide attempts through drug overdose. Methods: We performed a descriptive, cross-sectional retrospective study, including all the cases of suicide attempts that hospitalized at pediatric intensive care unit between January 2015 and December 2020. Results: In the study period, 356 children of self-poisoning suicide occurred, 20 cases were excluded from the study. The mean age of the study population was 14.98 ± 1.53 years. Seventy (20.8%) children were within 10-13 years with the predominance of female gender (female/male sex ratio: 3.35/1). Suicidal attempts were more common in females (p = 0.001). Considering the nature of attempt, toxic drug overdose (95.5%) appeared as the most frequent method of suicide, followed by intake of pesticides (4.5%). Antipyretics and antidepressants were the common pharmaceuticals involved in drug toxicity (21%, 19.3%). Conclusions: The present results showed that the majority of suicide attempts occurred during adolescence, with an increase in pre-adolescence at a considerable rate. Overall, it is important to increase the knowledge of pediatricians about suicide attempts in children and provide psychosocial support for children and their families as a preventive measure after their first attempt.
SIRT1, MMP-9 and TIMP-1 levels in children with specific learning disorder
(Elsevier, 2022) Mercan Işık, Cansu; Uzun Çiçek, Ayla; Ülger, Dilara; Bakır, Sevtap
ackground: Specific Learning Disorder (SLD) is a common developmental and neurobiological disorder of childhood characterized by impairment of functionality in one or more areas such as reading, writing, mathematics, listening, speaking, and reasoning. The etiology of SLD is still not fully understood. The aim of this study was to evaluate children with SLD to investigate the potential role of MMP-9, TIMP-1 and SIRT-1, which have important roles in synaptic plasticity, cognitive functions, learning and memory, and are known to be associated with various psychiatric disorders. Methods: The study was conducted with 44 outpatients aged 8-14 years who were diagnosed with SLD according to DSM-5 in the outpatient clinic and a control group of 44 age, gender and education level-matched healthy children. The groups were compared in respect of serum levels of MMP-9, TIMP-1 and SIRT-1, evaluated using the ELISA method. Results: Serum MMP-9 levels were significantly lower in children in the SLD group than in the control group, while TIMP-1 was higher. No difference was determined between the groups in respect of the SIRT1 levels. SLD severity was negatively correlated with MMP-9 levels and positively correlated with TIMP-1 levels. Conclusions: MMP-9 appear to contribute to hippocampal-dependent memory and learning by modulating long-term synaptic plasticity. The findings of this study also reinforce the idea that deregulation of the MMP-9/TIMP-1 ratio may impact learning and play a role in SLD. These findings will help to elucidate the etiology of SLD. Furthermore, understanding molecular pathways can contribute to the discovery of certain biomarkers in SLD pathogenesis and the development of new treatment possibilities.
Evaluation Of The Effect Of Adenotonsillectomy On Emotional And Behavioral Problems in Children
(KBB-Forum, 2023) Bora, Adem; Uzun Çiçek, Ayla
Objective: The aim of this study is to evaluate the effect of tonsillectomy and/or adenoidectomy (T&A) applied to children and adolescents with adenotonsillar hypertrophy (ATH) on externalizing and internalizing problems. Material and Methods: Physical and psychiatric symptoms that may be associated with ATH were evaluated with a questionnaire created by the researchers twice, before T&A surgery and at the 3rd month after surgery. Physical symptoms included the loss of appetite, snoring, and excessive daytime sleepiness. Psychiatric symptoms were enuresis (5 years and above), difficulty falling asleep, sleep talking, teeth grinding, difficulty waking up in the morning, hyperactivity, irritability and anger, damaging property, belligerent behavior, anxious mood, being tearful or sad, tics, attention deficit and concentration problems, language, speech and communication problems. Results: In the preoperative evaluation of symptoms that may be related to ATH, the most frequently reported physical symptom was the loss of appetite, while the most common psychiatric symptom was attention deficit and concentration problems. In postoperative evaluation, the symptoms showing the highest recovery rates were snoring and excessive daytime sleepiness. In addition, recovery rates for physical symptoms were higher than those for psychiatric symptoms. Conclusion: This study indicated that T&A has a curative effect on many psychiatric symptoms, especially snoring and excessive daytime sleepiness, seen in children with ATH. Still, further longitudinal studies are needed to confirm our findings to draw firm conclusions.
The Effect of Methylphenidate Treatment on Olfactory Function in Children and Adolescents With ADHD
(Journal of Attention Disorders, 06.05.2023) Mercan Işık,Cansu; Uzun Çiçek, Ayla; Altuntas, Emine Elif; Bora, Adem; Sarı, Seda Aybüke; Akkuş, Serdar
Objective: This study aimed to research whether there is an olfactory disorder in ADHD, and if so, what is the effect of methylphenidate on this condition. Method: This is a cross-sectional study aiming to evaluate olfactory threshold, identification, discrimination and threshold, discrimination, and identification (TDI) scores in 109 children and adolescents, 33 of whom have ADHD without medication, 29 with ADHD with medication and 47 control groups. Result: In the post hoc tests, the mean odor discrimination test, the mean odor identification test, and the mean TDI scores of the unmedicated ADHD group were significantly lower than those of the other two groups, and that the mean odor threshold test scores of the medicated ADHD group were significantly lower than those of the control and unmedicated groups. Conclusion: Olfactory function could be a useful tool to monitor treatment effects and may be a promising candidate as a biomarker in ADHD.
Evaluation of cognitive disengagement syndrome in children with obsessive-compulsive disorder: Clinical implications
(Clinical Child Psychology and Psychiatry, 18.04.2023) Uzun Çiçek, Ayla; Ucuz, İlknur; Mercan Işık, Cansu; Temelli, Gürkan
Cognitive disengagement syndrome (CDS) has been found to be associated with internalizing symptoms. Yet, no study thus far has focused on whether there is an association between obsessive- compulsive disorder (OCD) and CDS. The purpose of this study is to examine the symptom frequency and clinical implications of CDS in children with OCD. The study included sixty-one children with OCD and sixty-six typically developing children. Children were evaluated by a semi- constructed diagnosis interview, Obsessive-Compulsive Inventory, Barkley Child Attention Scale, and Stroop test. The frequency of elevated symptoms of CDS, and total time, total error, and total correction scores of the Stroop test were significantly higher in the OCD group compared to the controls. Elevated CDS symptoms were significantly associated with higher OCD symptom prevalence and poorer performance on the Stroop Test. Moreover, poor insight, hoarding symptoms, mental compulsions, and ADHD comorbidity were significantly higher in those with elevated CDS symptoms than in those without CDS in the OCD group. The findings of this study provide clinical implications that CDS symptoms may contribute to deficits in attentional orien- tation, conceptual flexibility, and cognitive processing speed in OCD.
Women's aesthetic perceptions of the genitalia and their association with anatomical measurements
(Springer-Verlag GmbH Germany, 18 February 2023) Derebaşınlıoğlu, Handan; Yıldız, Çağlar
Background: The purpose of this study is to determine women’s perceptions of the vulva with the criteria defned in the literature for the ideal vulva and determine their relationship with anatomical measurements to determine the extent to which women’s perceptions of normal align with our aesthetic standards of normality. Methods: First of all, a questionnaire was given to all participants. The items of the data collection form included personal information, obstetric and gynecological information, their perceptions of their external genitalia and any physical, sexual, psychological, and hygiene problems they experience. Then examination and measurements of the external genitalia were performed. Results: The majority of participants considered their genitalia normal (n=101, 89.4%), while 12 participants (10.6%) considered them abnormal. Statistical analyses showed that women’s perception of their genitalia as normal in appearance and size was associated with labia minora asymmetry (p=0.023 and p=0.006, respectively) and hyperpigmentation (p=0.010 and p=0.047, respectively) but not with labia minora measurements or protrusion (p>0.05). Conclusions: Although there is a tendency in the feld of aesthetic surgery to defne ideals and aesthetic standards for all parts of the body, our defnitions of normality do not always coincide with those of the individual. The appearance of the genitalia is as personal as the face, and an individual’s self-perception is more important than our ideal. Level IV Evidence obtained from multiple time series with or without the intervention, such as case studies. Dramatic results in uncontrolled trials might also be regarded as this type of evidence.
The Turkish version of the problem areas in diabetes-parents of teens (P-PAID-T): Cross-cultural adaptation, reliability, and validity
(2023) Sarı, Seda Atbüke; Ağadayı, Ezgi; Çelik, Nurullah; Karahan, Seher; Kömürlüoğlu Tan, Ayça; Döğer, Esra
Objective: To examine the Turkish validity and reliability of the Problem Areas in Diabetes- Parents of Teens (P PAID-T) scale and its psychometric properties for determining the parents’ diabetes-related distress. Methods: The study included the parents of 200 adolescents with T1DM for at least a year. P-PAID-T and a de mographic data form were used for data collection. Davis technique was used for the content validity of the scale. The scale’s reliability was tested using test-retest, and its internal reliability was analyzed with Cronbach’s alpha test. Exploratory Factor Analysis (EFA) was used to analyze the factor structure. Confirmatory Factor Analysis (CFA) was used to evaluate the fit of the scale. Results: 69.5% (n = 139) of the participants were mothers. Compared to the fathers, the mothers’ mean P-PAID-T score was significantly higher. Parents of sons, who used insulin injections for their children, and had a college degree or higher education level had higher P-PAID-T scores. The test-retest correlation coefficient of the scale was 0.977. The Cronbach α value of the scale was 0.901. The results of confirmatory factor analysis were x2/df = 2.931, GFI = 0.736, CFI = 0.711, NFI = 0.628, NNFI = 0.660, RMSEA = 0.141. Conclusion: The Turkish version of P-PAID-T was a valid and reliable screening tool for measuring diabetes stress in parents of adolescents with T1DM. Practice implications: Nurses could use the Turkish version of P-PAID-T to monitor parental diabetes distress and organize interventions; also Turkish P-PAID-T could facilitate research on diabetes distress for parents of ado lescents with T1DM.
Psychometric Properties of the Turkish Validity and Reliability of the Parent Diabetes Distress Scale
(2023) Karahan, Seher; Ağadayı, Ezgi; Sarı, Seda Atbüke; Çelik, Nurullah; Kömürlüoğlu Tan, Ayça; Döğer, Esra
Abstract Objective: The aim of this study was to evaluate the validity and reliability of the Turkish translation of the Parent Diabetes Distress Scale (PDDS). Methods: The PDDS is a 5-point Likert-type scale with 20 items. After obtaining permission from the scale developers, the study commenced. First, a systematic adaptation of the scale into the Turkish language was performed including translation, expert panel review, back translation, and pilot study. Test-retest was applied to 35 participants. After these procedures, data collection was undertaken using the adapted PDDS and a demographic data collection form. The collected data were analyzed for reliability, including stability of the scale with test-retest and internal consistency of the scale (Cronbach’s α), and validity including construct validity of the scale with confirmatory factor analysis (CFA). Results: The parents of 210 teenagers, aged >11 and <18 years, who had been diagnosed with type 1 diabetes mellitus for at least one year were included. Of these parents, 71.9% (n=151) were mothers and 53.3% (n=112) of the children were girls. The Cronbach’s α value was 0.906. The results of the CFA were χ2 /df=4.406, p<0.001, comparative fit test 0.704, and goodness of fit tests 0.749. The mean total PDDS score was 2.2±0.7. These results indicate that scores of 1.6 points or less was evaluated as “little or no distress” 1.7- 2.4 as “moderate distress,” and >2.4 points as “high distress”. This showed that the majority of the parents in the study experienced moderate or severe diabetes-related distress. Conclusion: The Turkish version of the PDDS fulfilled the validity and reliability tests at an acceptable level
Sleep quality and glycemic control in children and adolescents with type 1 diabetes mellitus
(2023) Berk, Erhan; Celik, Nurullah
Abstract. – OBJECTIVE: This study aimed to investigate the frequency of sleep disorders, and the relationship between glycemic control and sleep characteristics in diabetic children and adolescents. PATIENTS AND METHODS: Sixty-one pa tients followed for at least one year for type 1 diabetes mellitus (T1DM) aged 6-16 years old, and eighty-three group-matched healthy con trols were included in the study. Time in range (TIR) and hypoglycemia episode numbers were recorded using the freestyle libre sensor data. The sleep characteristics were evaluated using the Sleep Disturbance Scale for Children (SDSC) validated survey. The diabetic patients were tri chotomized according to SDSC scores, as low, medium, and high score groups. RESULTS: Sleep duration, SDSC total score, and subgroup scores except for sleep hyperhi drosis (3.11±1.53 vs. 2.16±0.85, p<0.001, respec tively) were similar (p>0.05) between the dia betic and control group. According to the sur vey, 1.6% of diabetic cases and 6.1% of the con trol group had clinically significant sleep distur bances (p>0.05). Duration of diabetes (DD) was lower (p=0.01), and the level of HbA1C was high er (p=0.02) in the high-score group than the oth ers. Regression analysis revealed that TIR was the only independent determinant for the SDSC score (β=-1.27, t=-1.90; p=0.012). CONCLUSIONS: Sleep habits and problems should be routinely evaluated in diabetic chil dren and adolescents.
Troponin-T value as a prognostic marker in neonates diagnosed with neonatal encephalopathy and receiving hypothermia treatment
(2023) Ünsal, Gülşah; Tunç, Gaffari; Taştanoğlu, Hüseyin; Çelik, Nurullah
Abstract. – OBJECTIVE: The aim of this study was to investigate the effect of Tropo nin-T levels on the prognosis of neonatal en cephalopathy (NE). PATIENTS AND METHODS: The study in cluded one hundred and eleven newborns diag nosed with NE and receiving hypothermia treat ment. The cases were separated into 2 groups according to the SARNAT classification as Stage 2 or Stage 3. The groups were compared in re spect of anthropometric characteristics, APGAR scores, and biochemical parameters. The cases were also separated into 3 groups according to the Troponin-T levels and were compared with respect to the clinical course. RESULTS: The serum Troponin-T (p=0.012), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) (p<0.0001), and lac tate levels (p=0.04) in the Sarnat Stage 3 group were statistically significantly higher than in the Sarnat stage 2 group. A significant positive correlation was determined between the Tropo nin-T level and the total duration of respirato ry support (r=0.20, p=0.03). A significant pos itive correlation was determined between the ALT/AST ratio and the length of stay in hos pital (r=0.29, p=0.001), duration of intubation (r=0.32, p=0.01), and total duration of respira tory support (r=0.36, p<0.001). A statistically significant difference was determined in mor tality rates between the 3 subgroups of Tropo nin-T levels; Group 1: 2.8%, Group 2:5.4%, and Group 3: 15.8%. (p=0.04, χ²=4.74). A cut-off val ue of 164 ng/L for Troponin-T was determined to predict mortality with 77% sensitivity and 67% specificity (AUC=0.73, p=0.023). When the groups were compared according to Troponin-T level, a statistically significant difference was determined in respect of length of stay in hos pital (p=0.03, χ²=6.95) and total duration of ox ygen support (p=0.01, χ²=9.12). CONCLUSIONS: The serum Troponin-T level can be evaluated as a prognostic marker in cas es followed up with a diagnosis of NE and re ceiving hypothermia treatment. There is a need for further prospective studies with larger sam ples on this subject.
Does Involvement in Peer Bullying Invite Self-Injury? The Association Between Peer Bullying and Self-Injury in a Clinical Sample
(Lippincott, 2023) Uzun Çiçek, Ayla; Ucuz, İlknur; Sarı, Seda Aybüke; Cömertoğlu Arslan, Semiha; Doğru, Hicran
Previous studies have linked peer bullying to nonsuicidal self-injury (NSSI). However, the evidence is largely limited to population-based groups. This study examined whether there is a relationship between NSSI and being a victim of peer bullying among adolescents in a clinical sample and how this may be influenced by types of bullying. The sample consisted of 96 outpatients with NSSI and 107 healthy adolescents. The Inventory of Statements About Self-Injury, Peer Bullying Scale, and Rosenberg Self-Esteem Scale were applied. Whereas the scores of each bullying type of adolescents with NSSI were significantly higher, their self-esteem scores were significantly lower. Each victimization score of bullying had a negative correlation with NSSI-onset age and self-esteem scores and a positive correlation with self-injury scores. This study demonstrated that being a victim of any type of bullying is strongly associated with self-injury. It would be advisable to screen adolescents with self-injury for exposure to bullying, and vice versa.
The Role of Childhood Trauma on Prenatal Attachment: A Cross-Sectional Study
(Lippincott, 2023) Can Çağlayan, İlkin Seda; Uzun Çiçek, Ayla; Yılmaz, Yavuz; Şahin, Ayşe Ecem
Although the quality of prenatal attachment is a strong predictor of the quality of postnatal mother-infant attachment and mother-child interaction, little is known about the specific impacts of maternal exposure to childhood traumas, and it deserves more attention. This study was conducted to determine whether there is a relationship between childhood traumas and pren1atal attachment levels. Prenatal attachment and childhood trauma were evaluated in 104 pregnant women using the Prenatal Attachment Scale and Childhood Trauma Questionnaire. Our results showed that all kinds of childhood traumatic experiences were associated with lower prenatal attachment scores. Also, more severe childhood traumas were strongly associated with weaker prenatal attachment. This study contributes to the very limited literature on the prenatal attachment of expectant mothers with childhood traumas by emphasizing the importance of pregnant women's exposure to childhood traumas as a risk factor for low prenatal attachment.
Clinical characteristics according to sex and symptom severity in children with selective mutism: a four-center study
(Taylor & Francis Online, 2023) Doğru, Hicran; Ucuz, İlknur; Uzun Çiçek, Ayla; Cömertoğlu Arslan, Semiha
Introduction: Clinical information regarding selective mutism (SM), a persistent and debilitating psychiatric disorder, in children is extremely limited. We aimed to examine sociodemographic characteristics and comorbid psychiatric conditions and identify clinical variables associated with sex and SM severity among children with SM. Methods: We analyzed the medical records of 49 children who received treatment for SM in four different tertiary hospitals in Turkey between 2016 and 2021. Children's charts were reviewed to examine clinical characteristics, comorbidities, and response to treatment. Results: Thirty-one children were female, and 18 were male (female:male ratio is 1.7:1). Most children (73.5%) with SM displayed onset of SM in 3-6 years. However, most children (57.1%) were diagnosed between the ages of 7-11. The mean time from onset to diagnosis was 1.69 ± 1.37 years. Females displayed a later onset of SM (6.42 ± 2.40 vs. 4.89 ± 0.96; p= 0.013) and higher comorbidity rates (71% vs. 38.9%, p= 0.039) than males. The vast majority of children received two or more psychiatric diagnoses. Children in the severe group had a longer duration of illness, higher rates of psychiatric comorbidity, speech delay, and treatment resistance. Conclusion: Our study suggests that SM may have different clinical features according to sex and symptom severity of SM. More information about children with SM is needed to understand the development and maintenance of SM.
Sociodemographic variables, clinical characteristics, and treatments in children with trichotillomania in terms of age and gender: a multicenter study
(Taylor & Francis Online, 2023) Cömertoğlu Arslan, Semiha; Uzun Çiçek, Ayla; Ucuz, İlknur; Doğru, Hicran
Objective: Although trichotillomania (TTM) is a common, typically pediatric-onset disorder, data on the phenomenology of TTM in children, accompanying comorbid psychiatric disorders, and treatment options are extremely limited. In our study, it was aimed to investigate these variables and related factors in patients undergoing psychiatric evaluation and follow-up. Method: The study included 79 children and adolescents between the ages of 4 and 17 who were diagnosed with TTM and followed up in four different Child and Adolescent Psychiatry outpatient clinics between 2015 and 2020. The sociodemographic characteristics of these patients, clinical features of the disease, comorbid psychiatric disorders, and treatment approaches have been studied. Results: Our results showed that TTM was more common in girls, hair and eyebrow plucking was the most common, and symptoms and features accompanying TTM changed with age, but not with gender. Again, 79.7% of these children had at least one psychiatric comorbid disorder (most common being anxiety disorders and Attention Deficit/Hyperactivity Disorder), comorbidity was closely related to TTM severity, 93.7% used at least one pharmacotherapeutic agent, and positive response rates to treatment were found to be low. Moreover, TTM severity was found to increase with age and disease duration. Conclusion: Study findings support that clinical presentation, disease severity and comorbidity rates may change with age in children and adolescents with TTM, and early intervention is important to prevent clinical progression/worsening and mental health sequela.
Validation of low-density lipoprotein cholesterol equations in pediatric population
(2023) Halef Okan Dogan
Several studies have shown a high prevalence of dyslipidemia in children. Since childhood lipid concentrations continue into adulthood, recognition of lipid abnormalities in the early period is crucial to prevent the development of future coronary heart disease (CHD). Low density lipoprotein cholesterol (LDL-C) is one of the most used parameters in the initiation and follow-up of treatment in patients with dyslipidemia. It is a well known fact that LDL-C lowering therapy reduces the risk of future CHD. Therefore, accurate determination of the LDL-C levels is so important for the management of lipid abnormalities. This study aimed to validate different LDL-C estimating equations in the Turkish population, composed of children and adolescents. A total of 3,908 children below 18 years old at Sivas Cumhuriyet University Hospital (Sivas, Turkey) were included in this study. LDL-C was directly measured by direct homogeneous assays, i.e., Roche, Beckman, Siemens and estimated by Friedewald's, Martin/Hopkins', extended Martin-Hopkins' and Sampson's formulas. The concordances between the estimations obtained by the formulas and the direct measurements were evaluated both overall and separately for the LDL-C, triglycerides (TG) and non-high-density lipoprotein cholesterol (non-HDL-C) sublevels. Linear regression analysis was performed and residual error plots were generated between each estimation and direct measurement method. Coefficient of determination (R 2) and mean absolute deviations were also evaluated. The overall concordance of Friedewald, Sampson, Martin-Hopkins and the extended Martin-Hopkins formula were 64.6%, 69.9%, 69.4%, and 84.3% for the Roche direct assay, 69.8%, 71.6%, 73.6% and 80.4% for the Siemens direct assay, 66.5%, 68.8%, 68.9% and 82.1% for the Beckman direct assay, respectively. The extended Martin-Hopkins formula had the highest concordance coefficient in both overall and all sublevels of LDL-C, non-HDL-C, and TG. When estimating the LDL-C categories, the highest underestimation degrees were obtained with the Friedewald formula. Our analysis, conducted in a large pediatric population, showed that the extended Martin-Hopkins equation gives more reliable results in estimation of LDL-C compared to other equations.
Assessment of semaphorin 3A and semaphorin 7A levels in primary Sjogren's syndrome
(Springer, 2023) Halef Okan Dogan
Sjogren's syndrome (SS) is a chronic autoimmune connective tissue disease. Varying rates of system involvements may be seen in the course of the disease. Semaphorins has multifunctions in several physiological and pathological processes such as immune system regulation. The association of Semaphorin 3A (Sema3A) and Semaphorin 7A (Sema7A), which are immune semaphorins, with autoimmune diseases is interesting for researchers. We aimed to compare serum Sema3A and Sema7A levels between primary SS and control subjects, and investigated Sema3A and Sema7A levels in disease subgroups and associated system involvements. 50 consecutive primary SS patients and 40 healthy subjects followed in the Rheumatology clinic of Cumhuriyet University Medical Faculty between 2017 and 2018 were included in the study. Inclusion criteria of patients were diagnosis of primary SS according to the 2016 ACR/EULAR classification criteria. Serum Sema3A and Sema7A levels were measured by commercial ELISA kit. Both groups were similar in terms of age, gender, and body mass index. Serum Sema3A and Sema7A levels were significantly lower in SS than in the controls (p = 0.001 and p = 0.005, respectively). Serum Sema3A levels were significantly lower in patients with renal involvement than in patients without (p = 0.03). Sema3A and Sema7A may play a role in the etiopathogenesis of SS and may be a potential serological marker for the diagnosis of SS and may be a target for treatment.
Determination of Ongoing Symptoms, Quality of Life Levels, and Risk Factors in Post-COVID-19 Patients
(MART 2022) GEDİKLİ, MUSTAFA ASIM; AKOVA, İREM
Objective: Studies have reported that most post-COVID-19 patients experience post-disease symptoms, but the results of these studies have not been interpreted correctly. The present study aimed to determine the ongoing symptoms and quality of life levels in post-COVID-19 patients. Materials and Methods: This cross-sectional research was carried out with 151 post-COVID-19 patients in Turkey. A sociodemographic data form and the general quality of life scale EQ-5D-5L were used. Results: Most of the participants completed outpatient COVID-19 treatment (93.4%). Of the participants, 84.7% had at least one post-COVID-19 symptom and 41.7% had six or more symptoms. Fatigue (70.9%), joint pain (45.7%), and muscle pain (38.4%) were the most common post-COVID-19 symptoms. The longest-lasting post-COVID-19 symptoms were hair loss (104.2±51.5 days), memory problem (101.9±53.3 days), and depression (96.3±48.6 days). The mean of the visual analog scale was 83.9±16.1 and lower in individuals with six or more post-COVID-19 symptoms (p=0.001). In female participants, post-COVID-19 symptoms increased by 2.7 times (p=0.020). The prevalence of certain COVID-19 symptoms was significantly higher in females (loss of smell, hair loss, and heart palpitation), those aged 40 years and older (intermittent fever), and obese individuals (heart palpitation and intermittent fever). Conclusion: Considering that post-COVID-19 symptoms can be seen in patients with mild illness at a high rate and for a long period of time, patient follow-up should be given importance especially for the females, elderly, and obese.
Clinical Characteristics and Outcome of COVID-19 in Turkish Hematological Malignancy Patients
(Turk J Hemato, 2022 şubat) CİVRİZ BOZDAĞ SİNEM; CENGİZ SEVAL GÜLDANE; YÖNAL HİNDİLERDEN İPEK; HİNDİLERDEN FEHMİ; ANDIÇ NESLİHAN; BAYDAR MUSTAFA; AYDIN KAYNAR LALE; TOPRAK SELAMİ KOÇAK; GÖKSOY HASAN SAMİ; BALIK AYDIN BERRİN; DEMİRCİ UFUK; CAN FERDA; ÖZKOCAMAN VİLDAN; GÜNDÜZ EREN; GÜVEN ZEYNEP TUĞBA; ÖZKURT ZÜBEYDE NUR; DEMİRCİOĞLU SİNAN; BEKSAÇ MERAL; İNCE İDRİS; YILMAZ UMUT; EROĞLU KÜÇÜKDİLER AYŞE HİLAL; ABİSHOV ELGÜN,; YAVUZ BORAN; ATAŞ ÜNAL; MUTLU YAŞA GÜL; BAŞ VOLKAN; ÖZKALEMKAŞ FAHİR; ÜSKÜDAR TEKE HAVA; GÜRSOY VİLDAN; ÇELİK SERHAT; ÇİFTÇİLER RAFİYE; YAĞCI ABDULLAH MÜNCİ; TOPÇUOĞLU PERVİN; ÇENELİ ÖZCAN; ABBASOV HAMZA; SELİM CEM; AR MUHLİS CEM; YÜCEL ORHAN KEMAL; SADRİ SEVİL; ALBAYRAK YAŞAR CANAN; DEMİR AHMET MUZAFFER; GÜLER NİL; KEKLİK MUZAFFER; TERZİ HATİCE; DOĞAN ALİ; YEGİN ZEYNEP ARZU; KURT YÜKSEL MELTEM; SADRİ SOĞOL; YAVAŞOĞLU İRFAN; Hüseyin Saffet Beköz; Tekin Aksu; Senem Maral; Veysel Erol; Leylagül Kaynar; İLHAN OSMAN; BOLAMAN ALİ ZAHİT; SEVİNDİK ÖMÜR GÖKMEN; AKYAY ARZU; ÖZCAN MUHİT; GÜRMAN GÜNHAN; CANGÜL ÜNAL ŞULE; YAVUZ YASEMİN; KÜÇÜKKAYA DİZ REYHAN; ÖZSAN GÜNER HAYRİ
Objective: Patients with solid malignancies are more vulnerable to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection than the healthy population. The outcome of SARS-CoV-2 infection in highly immunosuppressed populations, such as in patients with hematological malignancies, is a point of interest. We aimed to analyze the symptoms, complications, intensive care unit admissions, and mortality rates of patients with hematological malignancies infected with SARS-CoV-2 in Turkey. Materials and Methods: In this multicenter study, we included 340 adult and pediatric patients diagnosed with SARS-CoV-2 from March to November 2020. Diagnosis and status of primary disease, treatment schedules for hematological malignancies, time from last treatment, life expectancy related to the hematological disease, and comorbidities were recorded, together with data regarding symptoms, treatment, and outcome of SARS-CoV-2 infection. Results: Forty four patients were asymptomatic at diagnosis of SARS CoV-2 infection. Among symptomatic patients, fever, cough, and dyspnea were observed in 62.6%, 48.8%, and 41.8%, respectively. Sixty nine (20%) patients had mild SARS-CoV-2 disease, whereas moderate, severe, and critical disease was reported in 101 (29%), 71 (20%), and 55 (16%) patients, respectively. Of the entire cohort, 251 (73.8%) patients were hospitalized for SARS-CoV-2. Mortality related to SARS-CoV-2 infection was 26.5% in the entire cohort; this comprised 4.4% of those patients with mild disease, 12.4% of those with moderate disease, and 83% of those with severe or critical disease. Active hematological disease, lower life expectancy related to primary hematological disease, neutropenia at diagnosis of SARS-CoV-2, ICU admission, and first-line therapy used for coronavirus disease-2019 treatment were found to be related to higher mortality rates. Treatments with hydroxychloroquine alone or in combination with azithromycin were associated with a higher rate of mortality in comparison to favipiravir use. Conclusion: Patients with hematological malignancy infected with SARS-CoV-2 have an increased risk of severe disease and mortality.
Bioymifi suppresses Burkitt’s lymphoma cell line proliferation via cell cycle arrest and apoptosis
(Tropical Journal of Pharmaceutical Research, 2022 Ekim) Terzi Hatice; İnanır Merve
Purpose: To find a new treatment alternative for Burkitt’s lymphoma, one of the B cell-derived non Hodgkin's lymphomas that has an extremely aggressive growth profile with a high mortality rate. Methods: Bioymifi (death receptor agonist) was administered at various doses to Human Burkitt's Lymphoma Raji cell lines, and cell proliferation was evaluated using XTT analysis. Apoptosis induction and cell cycle analysis were assessed using flow cytometry. Results: Bioymifi exhibited good cytotoxicity in Raji cell lines with IC50 value of 29.5 µM. Furthermore, results of apoptosis induction and cell cycle analysis indicated that Bioymifi had potent anti-proliferative activity through sub-S cell cycle arrest and stimulation of apoptosis (p < 0.05). Conclusion: Bioymifi has anticancer potentials against Human Burkitt's Lymphoma Raji cell lines. Further pharmacological studies will be required to establish the mechanism of action.

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