Major Depresif Bozuklukta Artmış High Mobility Group Box1 (HMGB1) Düzeyi
Küçük Resim Yok
Tarih
2015
Yazarlar
Süleyman Demir
Mahmut Bulut
Mehmet Cemal Kaya
Bünyamin Sevim
Özlem Demirpençe
Aslıhan İbiloğlu Okan
Mehmet Güneş
Abdullah Atlı
Yasin Bez
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Nükleer transkripsiyon faktörü olarak bilinen High Mobility Group Box1 (HMGB1)’in inflamasyonun geç göstergesi olduğu bildirilmiştir. HMGB1’in proinflamatuar göstergeler olan Tümör Nekroz Faktör-? (TNF-?), Interlökin (IL)-1? ve IL-8 aktivasyonunda önemli bir rolü olduğu düşünülmektedir. HMGB1 bağışıklık sistem hastalıklarının seyrinde, teşhis ve hastalık prognozunun belirlenmesinde rol oynamaktadır. Majör Depresif Bozukluğun (MDB) bağışıklık sistemi baskılamasının yanı sıra inflamatuar süreçlerde değişikliğe neden olduğu anlaşılmıştır. Depresyonda tanı, tedavi ve prognozu etkileyen biyolojik belirleyiciler oldukça sınırlıdır. Bu nedenle depresyon patofizyolojisini açıklamak için yeni etiyolojik modeller gerekmektedir. Literatürde insanlarda MDB’de HMGB1 düzeyini inceleyen çalışma bulunmamaktadır. Biz bu çalışmada MDB tanılı hastalarda HMGB1 düzeyini değerlendirerek inflamasyo- nun depresyon etiyolojisindeki yerini açıklamayı amaçladık Yöntem: Hasta grubu MDB tanılı 30 kişiden, kontrol grubu ise herhangi bir psikiyatrik rahatsızlığı olmayan sağlıklı 30 kişiden oluşmaktaydı. Katılımcılara bilgilendirilmiş gönüllü olur formu imzalatıldıktan sonra sosyodemografik bilgi formu ve Hamilton Depresyon Derecelendirme Ölçeği (HDDÖ), Klinik Global İzlem Ölçeği (KGİÖ) uygulandı. HMGB1 düzeyinin ölçümü için kan alındı. Bulgular: Hasta grubunun HMGB1 düzeyinin kontrol grubuna göre istatistiksel olarak anlamlı düzeyde yüksek olduğu görüldü (p<0.05). Sonuç: Bu çalışma MDB’de HMGB1 düzeyinin insanlarda araştırıldığı ilk çalışmadır. Sağlıklı kontrollerle karşılaştırıldığında HMGB1, MDB tanılı hastalarda daha yüksek bulunmuştur. Yüksek HMGB1, MDB etiyolojisinde inflamasyonun önemli bir etmen olabileceği görüşünü desteklemektedir.
Objective: It was reported that High Mobility Group Box 1 (HMGB1), also known as the nuclear transcription factor, is a late mediator of inflammation. It was thought that HMGB1 has a prominent role in the activation of Tumor Necrosis Factor-&#945; (TNF-&#945;), Interleukin (IL)-1&#946; and IL-8 which are proinflammatory mediators during inflammation. HMGB1 plays a role in progress, diagnosis and prognosis of immune system illnesses. Besides suppressing the immune system, Major Depressive Disorder (MDD) was indicated to cause changes in inflammatory processes. Biological determinants affecting the diagnosis, therapy, and prognosis of depression are quite limited. Therefore, new etiological models are needed to explain the pathophysiology of depression. There is no study in the literature investigating level of HMGB1 in MDD of the humans. This study aims to examine the role of inflammation in the etiology of depression based on the HMGB1 in patients with MDD. Methods: A total of 30 patients diagnosed with MDD were included in the study. The control group consisted of 30 healthy subjects without any psychiatric disorders. A socio-demographic information form, Hamilton Depression Rating Scale (HDRS) and Clinical Global Impression Scale (CGIS) were administered, and blood was taken for measurement of HMGB1 levels. Results: Significantly higher HMGB1 values were identified with the patient group when compared to the control group (p<0.05). Conclusion: Our study is the first in which HMGB1 level was investigated in MDD ot the humans. The findings of the study reveal that HMGB1 tends to be higher in patients with MDD, and a high HMGB1 value supports the view that inflammation might have a critical role in the etiology of MDD.
Objective: It was reported that High Mobility Group Box 1 (HMGB1), also known as the nuclear transcription factor, is a late mediator of inflammation. It was thought that HMGB1 has a prominent role in the activation of Tumor Necrosis Factor-&#945; (TNF-&#945;), Interleukin (IL)-1&#946; and IL-8 which are proinflammatory mediators during inflammation. HMGB1 plays a role in progress, diagnosis and prognosis of immune system illnesses. Besides suppressing the immune system, Major Depressive Disorder (MDD) was indicated to cause changes in inflammatory processes. Biological determinants affecting the diagnosis, therapy, and prognosis of depression are quite limited. Therefore, new etiological models are needed to explain the pathophysiology of depression. There is no study in the literature investigating level of HMGB1 in MDD of the humans. This study aims to examine the role of inflammation in the etiology of depression based on the HMGB1 in patients with MDD. Methods: A total of 30 patients diagnosed with MDD were included in the study. The control group consisted of 30 healthy subjects without any psychiatric disorders. A socio-demographic information form, Hamilton Depression Rating Scale (HDRS) and Clinical Global Impression Scale (CGIS) were administered, and blood was taken for measurement of HMGB1 levels. Results: Significantly higher HMGB1 values were identified with the patient group when compared to the control group (p<0.05). Conclusion: Our study is the first in which HMGB1 level was investigated in MDD ot the humans. The findings of the study reveal that HMGB1 tends to be higher in patients with MDD, and a high HMGB1 value supports the view that inflammation might have a critical role in the etiology of MDD.
Açıklama
Anahtar Kelimeler
Psikiyatri
Kaynak
Journal of Mood Disorders
WoS Q Değeri
Scopus Q Değeri
Cilt
5
Sayı
4