Determination of anticancer properties and inhibitory effects of some metabolic enzymes including acetylcholinesterase, butyrylcholinesterase, alpha-glycosidase of some compounds with molecular docking study

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dc.authoridErden, Yavuz/0000-0002-2807-6096
dc.authoridCelebioglu, Hasan Ufuk/0000-0001-7207-2730
dc.authoridTaslimi, Parham/0000-0002-3171-0633
dc.authoridGulcin, ilhami/0000-0001-5993-1668
dc.authoridTUZUN, BURAK/0000-0002-0420-2043
dc.contributor.authorTurkan, Fikret
dc.contributor.authorTaslimi, Parham
dc.contributor.authorAbdalrazaq, Sakar Mubarak
dc.contributor.authorAras, Abdulmelik
dc.contributor.authorErden, Yavuz
dc.contributor.authorCelebioglu, Hasan Ufuk
dc.contributor.authorTuzun, Burak
dc.date.accessioned2024-10-26T18:11:05Z
dc.date.available2024-10-26T18:11:05Z
dc.date.issued2021
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractInhibitory effect of the complexes on some metabolic enzyme demonstrated that the enzymes inhibited by ligand and it's complex molecules at the micromolar level. The best inhibition effect for alpha-glycosidase (alpha-Gly) enzyme against cobalt complex with Ki value of 3.77 +/- 0.58 mu M. For achethylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes against SM-Co complex, Ki values of 74.23 +/- 5.02 mu M and 101.21 +/- 12.84 mu M Ki were observed, respectively. Molecular docking studies were performed to compare the biological activities of ligands and ligand complexes against enzymes whose names are AChE for ID 4M0E, BChE for ID 5NN0, alpha-Gly for ID 1XSI respectively. Also, anticancer properties of the complexes studied. The doses of all compounds caused significant reductions in MCF-7 cell viability. Zr compound showed the best cytotoxic activity against the MCF-7 cell. SM ligand administered to PC-3 cells exhibited a more pronounced cytotoxic effect than the SM-Co and Zr compounds. Communicated by Ramaswamy H. Sarma
dc.description.sponsorshipScientific Research Project Fund of Sivas Cumhuriyet University [RGD-020]
dc.description.sponsorshipThis work is supported by the Scientific Research Project Fund of Sivas Cumhuriyet University under project number RGD-020.
dc.identifier.doi10.1080/07391102.2020.1768901
dc.identifier.endpage3702
dc.identifier.issn0739-1102
dc.identifier.issn1538-0254
dc.identifier.issue10
dc.identifier.pmid32406329
dc.identifier.scopus2-s2.0-85087055373
dc.identifier.scopusqualityQ2
dc.identifier.startpage3693
dc.identifier.urihttps://doi.org/10.1080/07391102.2020.1768901
dc.identifier.urihttps://hdl.handle.net/20.500.12418/30507
dc.identifier.volume39
dc.identifier.wosWOS:000542889300001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofJournal of Biomolecular Structure & Dynamics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAnticancer
dc.subjectenzyme inhibition
dc.subjectmolecular docking
dc.subjectmacrocyclic compounds
dc.subjectacetylcholinesterase
dc.subjectbutyrylcholinesterase
dc.subjectalpha-glycosidase
dc.titleDetermination of anticancer properties and inhibitory effects of some metabolic enzymes including acetylcholinesterase, butyrylcholinesterase, alpha-glycosidase of some compounds with molecular docking study
dc.typeArticle

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