Joha, ZiadYıldırım, SahınHacısüleyman, LeventTaşkıran, Ahmet Şevki2024-10-262024-10-2620232587-26802587-246Xhttps://doi.org/10.17776/csj.1060972https://search.trdizin.gov.tr/tr/yayin/detay/1162880https://hdl.handle.net/20.500.12418/23440Despite the fact that narcotics and NSAIDs are the mainstays of nociceptive pain care, only a small proportion of neuropathic pain patients benefit from them. Cannabinoid agents could be a viable alternative to opioids in the management of chronic pain. The goal of our investigation was to assess the analgesic efficacy of SER 601 and L-759,633, cannabinoid receptor 2 (CB2) agonists, at various doses in a model of neuropathic pain generated in rat. The analgesic effect of CB2 agonists L-759,633 and SER 601 at various doses in a rat model of neuropathic pain created by partial sciatic nerve ligation was examined by the hot plate method. Furthermore, a comparison of analgesic effects of both drugs with pregabalin is also conducted. The two substances demonstrated a dose-dependent analgesic effect in this model. The analgesic response of SER601 and L-759,633 in the neuropathic pain model was higher compared to that of pregabalin. All in all, our data suggest that SER601 and L-759,633 may offer a beneficial treatment option for neuropathic pain in future.en10.17776/csj.1060972info:eu-repo/semantics/openAccessNeuropathic painL-759633SER 601Hot platePregabalin.Article44145411162880