Tutar, UğurGezegen, Hayreddin2024-03-082024-03-0802.10.2023https://hdl.handle.net/20.500.12418/15083In this study aimed to the synthesis of novel bis-nicotinonitrile derivatives starting from 1,3-bis-chalcones and investigate their antimicrobial activity potentials. Bis-nicotinonitrile derivatives were synthesized from 1,3-bis-chalcone derivatives reacted with malononitrile in ethanol in the presence of potassium carbonate. Characterization of the obtained compounds was carried out by spectroscopic methods. In total, 12 new 1,3- phenylene-bis-nicotinonitrile derivatives were synthesized. Finally, the antimicrobial and antibiofilm activities of synthesized 1,3-phenylene-bis-nicotinonitrile derivatives were tested against 5 microorganisms. As a result, it was observed that the synthesized new nicotinonitrile derivatives were quite active especially in terms of antibiofilm activity.eninfo:eu-repo/semantics/restrictedAccessAntibiofilm · Antifungal · Antimicrobial · 1,3-Bischalcone · NicotinonitrileArticle2-s2.0-85173753749N/AWOS:001074815900001Q3