Akkar, Ozlem BozokluSancakdar, EnverKarakus, SavasYildiz, CaglarAkkar, IsmailArslan, MuratSahin, Irfan OguzYenicesu, Ayse Gonca ImirCetin, Ali2019-07-272019-07-282019-07-272019-07-2820161643-3750https://dx.doi.org/10.12659/MSM.897983https://hdl.handle.net/20.500.12418/7377Background: The aim of this study was to evaluate the association of maternal serum 25-hydroxyvitamin D, paraoxonase 1, and neutrophil-to-lymphocyte ratio in women having early spontaneous preterm birth without clinical chorioamnionitis. Material/Methods: This study was prospectively administered in women referred to our obstetrics service with preterm labor that resulted in preterm birth (n=35) and term labor that ended in term birth (n=44). The maternal serum levels of 25-hydroxyvitamin D and paraoxonase 1 were measured and neutrophil-to-lymphocyte ratio was calculated. Results: The 25-hydroxyvitamin D and paraoxonase 1 levels of the preterm group were significantly lower than those of the term group (p<0.05). The neutrophil-to-lymphocyte ratio value of the preterm group was significantly higher than that of the term group (p<0.05). There was a significant but small positive correlation between the serum levels of 25-hydroxyvitamin D and paraoxonase 1 in the preterm group (r=0.35; p=0.021). Conclusions: Decreased maternal serum 25-hydroxyvitamin D and paraoxonase 1 levels and increased neutrophil-to-lymphocyte ratio may have a role in the etiology of spontaneous preterm birth.en10.12659/MSM.897983info:eu-repo/semantics/openAccess25-hydroxyvitamin DNeutrophil to Lymphocyte RatioParaoxonase 1Preterm BirthArticle2212431238270727802-s2.0-84963607010Q2WOS:000374178600001Q3