Dogdus, MustafaDindas, FerhatYenercag, MustafaYildirim, ArafatAbacioglu, Ozge OzcanKilic, SalihYavuz, Fethi2024-10-262024-10-2620230003-31971940-1574https://doi.org/10.1177/00033197221129356https://hdl.handle.net/20.500.12418/30637As inflammation plays a significant role in the development of coronary artery disease, we hypothesized that there may be a relation between the systemic immune inflammation index (SII) and saphenous vein graft disease (SVGD). The study population consisted of 716 consecutive patients who underwent elective coronary angiography (CAG) >1 year after bypass grafting. The patients were divided into 2 groups depending on the extent of SVG patency. SII value was significantly higher in the SVGD(+) group compared with the SVGD(-) group (P < .001). In multivariate logistic regression analysis, SII (P < .001, odds ratio (OR) = 3.27, 95% CI = 1.94-5.65) and neutrophil-to-lymphocyte ratio (NLR) (P < .001, OR = 2.08, 95% CI = 1.59-3.11) were found to be independent predictors of SVGD. An SII value of >935 (x10(3)/ml) has 89.2% sensitivity and 70.6% specificity for the prediction of the SVGD, and an NLR value of >4.15 has 54.6% sensitivity and 68.5% specificity for the prediction of the SVGD. The AUC of SII was found to be greater than the AUC of NLR (P = .002), platelet-to-lymphocyte ratio (PLR) (P = .009), lymphocyte-to-monocyte ratio (LMR) (P = .013), MPV (P = .011), and C-reactive protein (CRP) (P = .034) in predicting SVGD. In conclusion, we demonstrated that SII, which is among the new inflammation indexes, is a more reliable predictor in determining SVGD than the NLR, PLR, and LMR.en10.1177/00033197221129356info:eu-repo/semantics/closedAccesssystemic immune inflammation indexneutrophil-to-lymphocyte ratioplatelet-to-lymphocyte ratiolymphocyte-to-monocyte ratiosaphenous vein graft diseaseArticle746586579361544932-s2.0-85139132465Q2WOS:000859264100001Q3