Coban Buyukbayraktar, ZeynepDoruk, CenkDogan, MansurErtas, Gokcan2024-10-262024-10-2620221434-52931615-6714https://doi.org/10.1007/s00056-021-00316-zhttps://hdl.handle.net/20.500.12418/29434Purpose This parallel trial aimed to evaluate the changes in nasal mucociliary clearance (MCC) after a rapid maxillary expansion (RME) protocol or an alternating rapid maxillary expansion and constriction (Alt-RAMEC) protocol in orthodontic patients. Methods This trial included 36 patients with a mean age of 14.38 years, with a narrow maxillary arch, bilateral posterior crossbite, no narrowing of the mandibular arch, no previous orthodontic treatment, and no nasal or systemic disease. Patients were randomly distributed into two groups (n = 18 each)-one group was treated with the RME protocol and the other group was treated with the Alt-RAMEC protocol. MCC was evaluated using the saccharine transit time (STT) test, which was measured for each individual before expansion (T0), after expansion (T1), and after a 4-month retention phase (T2). The study was single blinded, and blinding was applied only to the outcome assessor. The primary objective was to evaluate the effect of the Alt-RAMEC and RME protocols on MCC. The secondary objective was to determine the relationship between age, sex, and MCC. The chi (2) test and independent samples t-test were used to evaluate the data. Results The STT decreased after expansion and retention in the RME group. In the Alt-RAMEC group, the STT decreased after expansion and slightly increased after retention. When the RME and Alt-RAMEC groups were compared, the STT showed a significant difference after expansion and retention (p < 0.05). No significant relationship was observed between age and sex and STT (p > 0.05). Conclusion This study demonstrated that the Alt-RAMEC protocol improved MCC and had a positive effect on nasal physiology by increasing the nasal volume more than that achieved by RME.en10.1007/s00056-021-00316-zinfo:eu-repo/semantics/closedAccessCorrective orthodonticsSaccharine transit time testPalatal expansion techniqueRetrognathiaJaw abnormalitiesArticle836402395341910342-s2.0-85108960983Q1WOS:000668438700001Q3