Karakus, Gulderen2019-07-272019-07-282019-07-272019-07-2820151309-0801https://hdl.handle.net/20.500.12418/8022Poly(maleic anhydride-co-styrene) (MAST), poly(maleic anhydride-co-vinyl acetate) (MAVA), poly(maleic anhydride-co-methyl methacrylate) (MAMMA), poly(maleic anhydride-co-allyl phenyl ether) (MAAFE) and poly(maleic anhydride-alt-acrylic acid) (MAAA) copolymers were synthesized by free radical chain polymerization reaction. Modification/derivatization of the copolymers with active pharmaceutical ingredients, in amine form (-NH2), was performed by the ring opening reaction. Structural characterization of the copolymers and the conjugated products was carried out by Fourier Transform Infrared (FTIR) and Nuclear Magnetic Resonance (H-1-NMR). The FTIR and H-1-NMR spectra, confirmed that pharmaceutically active agents were covalently bonded to the MAVA copolymer in a succesfull manner. Furthermore cytotoxicity on healthy fibroblast cell lines, antiproliferative activity on cancer cell lines and antibacterial activity on bacterial strains were also investigated in-vitro for synthesized conjugates. MAVA copolymer was also selected the most suitable carrier for modification/derivaritization process by comparing its affinity to the pharmaceutically active agents.trinfo:eu-repo/semantics/closedAccessCopolymer modificationring opening reactionantiproliferative activityantibacterial activitystructural characterizationArticle192125121WOS:000361222900006N/A