Pektas, Ayse NurKorkmaz, Ertan Mahir2025-05-042025-05-0420251028-60201477-2213https://doi.org/10.1080/10286020.2024.2448011https://hdl.handle.net/20.500.12418/35411Antimicrobial peptides are crucial components of the immune systems of both vertebrates and invertebrates. Here, defensins, the most studied class of antimicrobial molecules in arthropods were investigated in four coleopteran insect species: Harpalus rufipes (DeGeer, 1774), Mylabris quadripunctata (Linnaeus, 1767), Sphaeridium marginatum (Linnaeus, 1758), and Ocypus mus (Brull & eacute;, 1832). The peptides synthesized with over 95% purity and their antimicrobial activities were evaluated by MIC test method. As a result, it was determined that Mylabris quadripunctata defensin (MqDef) showed high antimicrobial activity against Staphylococcus aureus and MRSA, whereas Sphaeridium marginatum (SmDef) and Harpalus rufipes (HrDef) defensins against Candida tropicalis.en10.1080/10286020.2024.2448011info:eu-repo/semantics/closedAccessantimicrobial peptideAMPanticandidal activityColeopteradefensinMICArticle397867932-s2.0-85214680758Q2WOS:001392894100001Q3