Kurt, BegumOksuz, Kerim E.Sahin-Inan, Zeynep D.Hepokur, Ceylan2024-10-262024-10-2620230009-7411https://doi.org/10.24875/CIRU.23000097https://hdl.handle.net/20.500.12418/26540Objective: In this study, we aimed to compare the anti-adhesive effects of contractubex and dicalcium phosphate dihydrate (DCPD) particles in rats treated with the uterine horn adhesion model. Materials and methods: Newly adult, 60 Wistar albino rats were used as experimental animals. The modified rat uterine horn adhesion model was used to induce intra-abdominal adhesion. Tumor necrosis factor (TNF)-?, interleukin (IL)-1, vascular endothelial growth factor (VEGF) and transforming growth factor (TGF)-?1 were studied for biochemical and immunohistochemical examination. Results: TNF-? decreased in each group, while it decreased more in G2 and G3 than in G1. IL-1? decreased in each group, while it decreased the most in G3. TGF-?1 and VEGF localization was less in the G2 compared to G1, the least TGF-?1 and VEGF immunolocalization was detected in the G3 and G4. For both antibodies, the least localization among all groups belonged to G3. From day 7 to day 21, the highest TGF-?1 immunolocalization was observed in G1, lesser localization in G2 and lowest in G3. Conclusion: DCPD nanoparticles show promise as a clinical antiadhesive agent and should be further evaluated in experimental animal models and human trials. © 2023 Academia Mexicana de Cirugía.en10.24875/CIRU.23000097info:eu-repo/semantics/openAccessDicalcium phosphate dihydrate; Gynecologic surgery; Nanoparticles; Wistar ratsArticle914467457376779532-s2.0-85170172437Q4