Taşkın Kafa, Ayşe HümeyraTüzün, GamzeGüney, ElifAslan, RukiyeSayın, KorayTüzün,BurakAtaseven, Hilmi2023-06-222023-06-22Ağustos 20https://hdl.handle.net/20.500.12418/13965Newly designed nicotinamide derivatives were synthesized and characterized using spectral techniques (IR, 1H-NMR, 13C-NMR, and MS). Moreover, these compounds are investigated computationally. B3LYP/6–31 + G(d,p) level is selected as the calculation level in this study. Experimental and calculated IR spectrum were compared to each other. Electronic properties of synthesized compounds are examined using HOMO/LUMO contour plot and MEP maps. Antibacterial activity and antibiofilm properties are investigated experimentally. Additionally, antibacterial properties of studied compounds are investigated by molecular docking analyses. As a result, ND4 was found as the best inhibitor candidate against Enterococcus faecalis.eninfo:eu-repo/semantics/openAccessArticle2-s2.0-85127576509N/AWOS:000778056600004Q3