Ocal, PelinSahmay, SezaiCetin, MeralIrez, TulayGuralp, OnurCepni, Ismail2019-07-272019-07-282019-07-272019-07-2820111058-0468https://dx.doi.org/10.1007/s10815-011-9627-4https://hdl.handle.net/20.500.12418/9396Objective To evaluate predictive role of day-3 serum anti-Mullerian hormone (AMH) levels and antral follicle count (AFC) in ovarian hyperstimulation syndrome (OHSS) in patients undergoing IVF/ICSI cycles. Materials and methods Forty-one women with moderate/severe OHSS and 41 age matched women without OHSS were compared to evaluate the predictive value of certain risk factors for OHSS. AFC, and E(2), FSH, LH, AMH, inhibin-B levels measured on day 3 of the menstrual cycle before controlled ovarian hyperstimulation. Results Mean FSH was significantly lower (p < 0.0001); and mean LH, AFC and AMH were significantly higher in women with OHSS compared to women without OHSS (p = 0.049, p < 0.0001 and p < 0.0001, respectively). There was no significant difference in inhibin B (p = 0.112) and estradiol (p = 0.706) between the groups. The ROC area under curve (AUC) for AMH presented the largest AUC among the listed risk factors. AMH (AUC = 0.87) and AFC (AUC = 0.74) had moderate accuracy for predicting OHSS while Inhibin B (AUC = 0.58) and LH (AUC = 0.61) had low accuracy. The cut-off value for AMH 3.3 ng/mL provided the highest sensitivity (90%) and specificity (71%) for predicting OHSS. It's positive (PPV) and negative predictive values (NPV) were 61% and 94%, respectively. The cut-off value for AFC was 8 with 78% sensitivity, 65% specificity, 52% PPV and 86% NPV. Conclusion Measurement of basal serum AMH and AFC can be used to determine the women with high risk for OHSS.en10.1007/s10815-011-9627-4info:eu-repo/semantics/openAccessAntimullerian hormoneOvarian hyperstimulation syndromeAntral follicle countArticle281212031197218820172-s2.0-84355166699Q2WOS:000298228400011Q2