Kurt, BegumYildiz, CaglarKoc, TulayKurt-Ozkaya, NeseCelikgun, Serkan2024-10-262024-10-2620230009-7411https://doi.org/10.24875/CIRU.23000070https://hdl.handle.net/20.500.12418/26539Objective: This study was carried out to investigate the effect of autologous platelet-rich plasma (PRP) on intra-abdominal adhesion at the cesarean section incision line in the uterus. Material and methods: As experimental animals 16 white New Zealand rabbits, 5-months-old, unmated, were used. Animals were divided into two groups the control group and PRP application group. In each group, a transverse incision was made to the uterus to mimic the cesarean section and sutured. Relaparotomy was performed 21 days after the first operation. Results: When the groups were evaluated in terms of inflammation, there was a significant difference between the two groups. When the groups were evaluated in terms of Mason’s Trichrome staining and fibrosis, There was a significant difference between groups. When the groups were evaluated in terms of vascular endothelial growth factor-1, there was also a significant difference between the groups. In an experimental rabbit uterine horn adhesion model, PRP is effective in preventing post-operative adhesion formation. Conclusions: This result may guide clinical studies using autologous PRP to prevent post-operative adhesion formation after gynecological operations. © 2023 Academia Mexicana de Cirugía. Published by Permanyer. This is an open access article under the terms of the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).en10.24875/CIRU.23000070info:eu-repo/semantics/openAccessGynecological surgery; Platelet-rich plasma; Post-operative complications- Repeat cesarean sections; Surgical adhesionsArticle916779773380968772-s2.0-85179774527Q4