Browsing by Author "Durmus, Nedim"
Now showing items 1-20 of 24
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Alterations in spontaneous contractions of rat ileum and jejunum after peritonitis
Koyluogu, Gokhan; Bageivan, Ihsan; Karadas, Baris; Guney, Cengiz; Durmus, Nedim; Altun, Ahmet; Kaya, Tijen (ELSEVIER SCIENCE BV, 2008)The aim of this study was to investigate the effects of peritonitis on spontaneous contractions of ileum and jejunum smooth muscles isolated from rats. Peritonitis was induced by cecal ligation and puncture in 8 rats. ... -
Attenuation of morphine antinociceptive tolerance by cannabinoid CB1 and CB2 receptor antagonists
Altun, Ahmet; Yildirim, Kemal; Ozdemir, Ercan; Bagcivan, Ihsan; Gursoy, Sinan; Durmus, Nedim (SPRINGER JAPAN KK, 2015)Cannabinoid CB1 and CB2 receptor antagonists may be useful for their potential to increase or prolong opioid analgesia while attenuating the development of opioid tolerance. The aim of this study was to investigate the ... -
Changes in spontaneous contractions of rat ileum by aflatoxin in vitro
Gursoy, Nevcihan; Sarac, Bulent; Durmus, Nedim; Parlak, Ahmet; Yildirim, Sahin; Kaya, Tijen; Bagcivan, Ihsan (PERGAMON-ELSEVIER SCIENCE LTD, 2008)Aflatoxins are a group of mycotoxins produced by toxigenic strains of Aspergillus flavus, Aspergillus parasiticus and Aspergillus nomius as secondary metabolites. Most of the studies on the aflatoxins have focused mainly ... -
Chemical Composition, Antioxidant, Antimicrobial and Antispasmodic Activities of the Essential Oil of Juniperus excelsa subsp excelsa
Atas, Ahmet Duran; Goze, Ismihan; Alim, Ahmet; Cetinus, Senay Akkus; Durmus, Nedim; Vural, Nilufer; Cakmak, Osman (TAYLOR & FRANCIS LTD, 2012)In this study, chemical composition, antioxidant, antimicrobial and antiospasmodic activities of the essential oil of the berries Juniperus excelsa Bieb. subsp. excelsa were evaluated in vitro. GC and GS-MS analysis of the ... -
Effects of alpha 2-adrenoceptor agonists dexmedetomidine and guanfacine on morphine analgesia and tolerance in rats
Gursoy, Sinan; Ozdemir, Ercan; Bagcivan, Ihsan; Altun, Ahmet; Durmus, Nedim (TAYLOR & FRANCIS LTD, 2011)Background. Alpha 2 (alpha(2))-adrenoceptor agonists may be useful for their potential to increase or prolong opioid analgesia while attenuating the development of opioid tolerance. The purpose of this study was to investigate ... -
Effects of Cannabinoid Agonists on Sheep Sphincter of Oddi in vitro
Sarac, Bulent; Durmus, Nedim; Altun, Ahmet; Turan, Mustafa; Kaya, Tijen; Sencan, Mehmet; Bagcivan, Ihsan (ELSEVIER SCIENCE BV, 2011)Background/Aims: According to recent studies, the endocannabinoid system plays an important role in both physiological and pathophysiological situations. The purpose of the present study was to investigate the effects of ... -
The effects of endocannabinoid receptor agonist anandamide and antagonist rimonabant on opioid analgesia and tolerance in rats
Altun, Ahmet; Ozdemir, Ercan; Yildirim, Kemal; Gursoy, Sinan; Durmus, Nedim; Bagcivan, Ihsan (GENERAL PHYSIOL AND BIOPHYSICS, 2015)The role of the cannabinoid (CB) system in the tolerance to analgesic effect of opioid remains obscure. The aim of the present study was to evaluate the effects of the endocannabinoid nonselective receptor agonist anandamide ... -
Effects of formoterol and BRL 37344 on human umbilical arteries in vitro in normotensive and pre-eclamptic pregnancy
Karadas, Baris; Kaya, Tijen; Cetin, Meral; Parlak, Ahmet; Durmus, Nedim; Bagcivan, Ihsan; Gulturk, Sefa (ELSEVIER SCIENCE INC, 2007)Alterations in vascular responses to beta-adrenoceptor agonists in normotensive pregnancy and pre-eclampsia are not fully understood. Thus, we studied changes in vasodilator responses to beta(2)-adrenoceptor agonist ... -
Evaluation of effects of T and N type calcium channel blockers on the electroencephalogram recordings in Wistar Albino Glaxo/Rij rats, an absence epilepsy model
Durmus, Nedim; Gulturk, Sefa; Kaya, Tijen; Demir, Tuncer; Parlak, Mesut; Altun, Ahmet (MEDKNOW PUBLICATIONS & MEDIA PVT LTD, 2015)Objectives: It is suggested that excessive calcium entry into neurons is the main triggering event in the initiation of epileptic discharges. We aimed to investigate the role of T and N type calcium channels in absence ... -
Evaluation of urinary bladder function after acute spinal cord injury: an experimental study
Oztemur, Zekeriya; Tezeren, Guenduez; Bagcivan, Ihsan; Sarac, Buelent; Durmus, Nedim; Egilmez, Reyhan (TURKISH JOINT DISEASES FOUNDATION, 2010)Objectives: The aim of this study was to evaluate the efficacy of early surgical decompression of acute spinal cord injury through the evaluation of urinary bladder function in rabbits. Materials and methods: The study was ... -
In Vitro Antimicrobial, Antioxidant, and Antispasmodic Activities and the Composition of the Essential Oil of Origanum acutidens (Hand.-Mazz.) Ietswaart
Goze, Ismihan; Alim, Ahmet; Cetinus, Senay Akkus; Cetin, Ali; Durmus, Nedim; Atas, Ahmet Turan; Vural, Nilufer (MARY ANN LIEBERT INC, 2010)The radical scavenging, antimicrobial, and antispasmodic activities and the composition of Origanum acutidens (Hand.-Mazz.) Ietswaart (Order Labiatte) essential oil were evaluated in vitro. Gas chromatography/mass spectrometry ... -
Investigation of acute effects of aflatoxin on rat proximal and distal colon spontaneous contractions
Gursoy, Nevcihan; Durmus, Nedim; Bagcivan, Ihsan; Sarac, Bulent; Parlak, Ahmet; Yildirim, Sahin; Kaya, Tijen (PERGAMON-ELSEVIER SCIENCE LTD, 2008)Aflatoxins are one of the most potent toxic, mutagenic, teratogenic, cancerogenic, and immunosuppresive substances that naturally Occurring contaminants of food. There are some studies in various animal species that have ... -
Investigation of Relaxant Effects of New Agents Affecting Nitric Oxide/Cyclic Guanosine Monophosphate Pathway on Sheep Oddi Sphincter
Sarac, Bulent; Durmus, Nedim; Bagcivan, Ihsan; Altun, Ahmet; Turan, Mustafa; Sencan, Mehmet (LIPPINCOTT WILLIAMS & WILKINS, 2010)Objectives: Nitric oxide (NO) is a potent nonadrenergic, noncholinergic mediator of gastrointestinal smooth muscle. We aimed to investigate the effects of new NO/cyclic guanosine monophosphate (cGMP) pathway-affecting ... -
Investigation of the Cardiac Effects of Pancuronium, Rocuronium, Vecuronium, and Mivacurium on the Isolated Rat Atrium
Gursoy, Sinan; Bagcivan, Ihsan; Durmus, Nedim; Kaygusuz, Kenan; Kol, Iclal Ozdemir; Duger, Cevdet; Yildirim, Sahin; Mimaroglu, Caner (ELSEVIER SCIENCE INC, 2011)BACKGROUND: Pancuronium, vecuronium, rocuronium, and mivacurium are nondepolarizing neuromuscular blocking agents that affect the cardiovascular system with different potencies. Their cardiovascular effects are clinically ... -
Investigation of the effects of magnetic field exposure on febrile seizure latency, seizure duration, and electroencephalographic recordings in a rat febrile convulsion model
Demir, Tuncer; Gulturk, Sefa; Demirkazik Cancalar, Ayse; Durmus, Nedim (TUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEY, 2014)Aim: To investigate the effects of a magnetic field (MF) on febrile seizure latency, seizure duration, and electroencephalographic (EEG) recordings in a rat febrile convulsion model. Materials and methods: Thirty-six rats ... -
Investigation of the relaxant effects of pancuronium, rocuronium, vecuronium and mivacurium on rat thoracic aorta
Gursoy, Sinan; Bagcivan, Ihsan; Durmus, Nedim; Kaygusuz, Kenan; Kol, Iclal Ozdemir; Yildirim, Sahin; Mimaroglu, Caner (LIPPINCOTT WILLIAMS & WILKINS, 2009)Background and objective Pancuronium, vecuronium, mivacurium and rocuronium are nondepolarizing neuromuscular blocking agents, which are competitive antagonists against acetylcholine at nicotinic receptors, and considered ... -
Mechanism of relaxation induced by nicotine in normal and ovalbumin-sensitized guinea-pig trachea
Cevit, Omer; Bagcivan, Ihsan; Sarac, Bulent; Parlak, Ahmet; Durmus, Nedim; Kava, Tiien (ELSEVIER SCIENCE BV, 2007)Nicotine is an irritant molecule in the cigarette that contributes airway hyper-reactivity. The aim of this study was to investigate the mechanism of these effects and effects of nicotine on the isolated trachea preparations ... -
Nifedipine Enhances the Relaxant Effects of Cyclo-Oxygenase Inhibitors on the Bovine Ciliary Muscle
Toker, Mustafa; Bagcivan, Ihsan; Topalkara, Aysen; Karadas, Baris; Durmus, Nedim; Parlak, Ahmet; Kaya, Tijen (MARY ANN LIEBERT, INC, 2008)Background/Aims: The inhibition of cyclo-oxygenase (COX) enzymes and the blockade of Ca2+ channels play an important role in the regulation of smooth muscle relaxation. This study was designed to investigate the relaxant ... -
The nitric oxide-cGMP signaling pathway plays a significant role in tolerance to the analgesic effect of morphine
Ozdemir, Ercan; Bagcivan, Ihsan; Durmus, Nedim; Altun, Ahmet; Gursoy, Sinan (CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS, 2011)Although the phenomenon of opioid tolerance has been widely investigated, neither opioid nor nonopioid mechanisms are completely understood. The aim of the present study was to investigate the role of the nitric oxide ... -
Ovariectomy enhances spike-wave discharges in WAG/Rij rats
Yildiz, Ozlem Kayim; Yildiz, Caglar; Durmus, Nedim; Gulturk, Sefa; Benek, Selim; Cetin, Ali (UNIVERSITATSVERLAG ULM GMBH, 2011)Objective: To determine the effect of withdrawal of ovarian hormones on the occurrence of absence seizures in WAG/Rij rats, a well-validated animal model for absence epilepsy. Methods: Two weeks after electroencephalography ...