Browsing by Author "Yildirim, S"
Now showing items 1-20 of 24
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Aging impairs nitric oxide-mediated relaxant responses of rabbit corporal smooth muscle
Utkan, T; Yildirim, S; Sarioglu, Y; Yildiz, F; Yildirim, K (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2002)Aging has been reported to cause impotence, the mechanism of which is unknown. Therefore, we investigated the effect of aging on electrical stimulation-induced neurogenic, carbachol-induced, endothelium-dependent, and ... -
Corporal reactivity to adenosine and prostaglandin E-1 in alloxan-induced diabetic rabbit corpus cavernosum, and the effect of insulin therapy
Ayan, S; Yildirim, S; Ucar, C; Sarioglu, Y; Gultekin, Y; Butuner, C (BLACKWELL SCIENCE LTD, 1999)Objective To investigate the changes in corporal reactivity to adenosine and prostaglandin E-1 (PGE(1)) in corpus cavernosal strips from alloxan-induced diabetic rabbits and to determine the effects of insulin therapy. ... -
Does diabetes mellitus affect the progress of tolerance to isosorbide dinitrate (ISDN) in corporal tissue?
Yildirim, S; Ayan, S; Sarioglu, Y; Gultekin, Y; Uma, S (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2000)For erection to take place, the penile arteries and sinusoids have to dilate, thereby increasing the blood flow into the penis. There is increasing evidence that release of L-arginine derived nitric oxide (NO) from ... -
Effect of additional testosterone on purinergic responses in isolated rabbit corpus cavernosum strips
Kaya, T; Sarioglu, Y; Goksu, OC; Yildirim, S; Yildirim, K (ACADEMIC PRESS LTD, 1998)Recently, it has been demonstrated that the endothelium of corpus cavernosum (CC) plays an important role on smooth muscle relaxation, which is crucial to initiate and maintain erection. We investigated the effect of ... -
Effect of chronic renal failure on the purinergic responses of corpus cavernosal smooth muscle in rabbits
Kilicarslan, H; Yildirim, S; Bagcivan, I; Ayan, S; Sarac, B; Sarioglu, Y (WILEY, 2002)Objective To examine purinergic relaxation responses in chronic renal failure (CRF) in an experimental rabbit model, and thus evaluate the possible involvement of the purinergic system in erectile dysfunction with CRF. ... -
Effect of hypothyroidism on the nitrergic relaxant responses of corpus cavernosal smooth muscle in rabbits
Sarac, B; Yildirim, MK; Bagcivan, I; Kaya, K; Kilicarslan, H; Yildirim, S (WILEY, 2006)Background: The incidence of hormonal dysfunction as a cause of impotence remains controversial. However, several recent studies have reported evidence of hormonal abnormalities in 25-35% of impotent men. Hypothyroidism ... -
Effects of castration on adrenergic, cholinergic and nonadrenergic, noncholinergic responses of isolated corpus cavernosum from rabbit
Yildirim, MK; Yildirim, S; Utkan, T; Sarioglu, Y; Yalman, Y (BLACKWELL SCIENCE LTD, 1997)Objective To investigate the effects of castration and testosterone on the constricting effect of phenylephrine and endothelium-dependent and -independent relaxing effects of different agonists in the corpus cavernosum of ... -
Effects of exogenous testosterone on isolated rabbit corpus cavernosum penis
Yildirim, S; Utkan, T; Yildirim, K; Sarioglu, Y (ACTA PHARMACOLOGICA SINICA, 2000)AIM: To study the effects of exogenous excess of testosterone on the constricting effect of phenylephrine and endothelium-dependent and -independent relaxing effects of different:agonists in the corpus cavernosum penis ... -
The effects of long-term oral administration of L-arginine on the erectile response of rabbits with alloxan-induced diabetes
Yildirim, S; Ayan, S; Sarioglu, Y; Gultekin, Y; Butuner, C (BLACKWELL SCIENCE LTD, 1999)Objective To investigate the effects of the long-term oral administration of L-arginine on the impaired neurogenic and endothelium-dependent relaxation responses of corpus cavernosum smooth muscle from alloxan-induced ... -
The effects of long-term oral L-arginine on the erectile response of rabbits with alloxan-induced diabetes - Reply
Yildirim, S; Ayan, S; Sarioglu, Y; Gultekin, Y; Butuner, C (BLACKWELL SCIENCE LTD, 1999)… -
Effects of the specific phosphodiesterase inhibitors on alloxan-induced diabetic rabbit cavernous tissue in vitro
Utkan, T; Yildirim, MK; Yildirim, S; Sarioglu, Y (NATURE PUBLISHING GROUP, 2001)An experimental study was done to examine a potential role of phosphodiesterase (PDE) inhibitors in the treatment of diabetic erectile dysfunction, Relaxant effect of specific PDE inhibitors were measured in strips of ... -
Enhancement of EFS-induced contractions, by agmatine, in guinea pig gallbladder smooth muscle strips
Yildirim, S; Aydin, C; Koyuncu, A; Bagcivan, I; Sarac, B; Sarioglu, Y (SPRINGER TOKYO, 2005)Background. Electrical field stimulation of gallbladder muscle strips produces frequency-dependent contractions by activating cholinergic nerves. The cholinergic motor function of the gallbladder and enteric system is also ... -
Evidence of relaxant effect of omeprazole in rabbit corpus cavernosum in vitro
Sarioglu, Y; Yildirim, S; Utkan, T; Yildirim, MK; Uma, S (PERGAMON-ELSEVIER SCIENCE LTD, 2000)The present experiments were designed to investigate the effects of omeprazole, a H+-K+ ATPase inhibitor, on corporal smooth muscle tone in vitro. All spontaneous contractile activity in the corpus cavernosum was blocked ... -
Hydrogen-potassium ATPase inhibitors induce relaxation on rabbit prostatic strips in vitro
Bagcivan, I; Gokce, G; Ayan, S; Yildirim, S; Sarac, B; Kilicarslan, H; Sarioglu, Y (WILEY, 2002)Background: To determine the relaxant effect of omeprazole and lansaprazole, hydrogen-potassium (H+ -K+ ) ATPase inhibitors, on rabbit prostatic tissue in vitro . Methods: Male New Zealand white rabbits were sacrificed and ... -
Impaired contraction and relaxation in the aorta of streptozotocin-diabetic rats
Utkan, T; Sarioglu, Y; Yildirim, S (KARGER, 1998)It is known that diabetes mellitus alters the vascular responsiveness to several vasoconstrictors and vasodilators. Endothelium-derived nitric oxide is a potent endogenous nitrovasodilator, and endothelin-1 (ET-1) is a ... -
Inhibitor effect of omeprazole in isolated human myometrial smooth muscle
Yildirim, K; Sarioglu, Y; Kaya, T; Cetin, A; Yildirim, S (PERGAMON-ELSEVIER SCIENCE LTD, 2001)The aim of the present study was to investigate the effect of omeprazole, an H+-K+-ATPase inhibitor, in myometrial smooth muscle strips from women undergoing elective caesarean section at term. Isolated myometrial strips ... -
Investigation of the mechanism of nicotine induced relaxation in rabbit corpus cavernosum in vitro
Bagcivan, I; Gokce, G; Yildirim, S; Sarioglu, Y (SPRINGER, 2004)In order to determine whether nicotine acts on corporal smooth muscle, the mechanism of its effect on strips of rabbit corpus cavernosum was studied in vitro. Rabbit corpus cavernosum muscle strips were mounted in an organ ... -
Relaxant effect of omeprazole and lansoprazole in guinea pig gallbladder muscle strips in vitro
Aydin, C; Sarac, B; Koyuncu, A; Yildirim, S; Sen, M; Sarioglu, Y (SPRINGER JAPAN KK, 2003)Background. The aim of this study was to investigate the role of omeprazole and lansoprazole, H+-K+ ATPase inhibitors, in gallbladder smooth muscle contractility in vitro. Methods. Gallbladder muscle strips obtained from ... -
Relaxant effects of some benzothiazolinone derivatives on isolated rabbit corpus cavernosum
Yildirim, S; Simek, R; Ayan, S; Gokce, G; Sarioglu, Y; Safak, C (SPRINGER-VERLAG, 2001)In the present study, two 6-(fluorobenzoyl)-3-piperazinomethyl-2benzothiazoline ne derivatives were synthesized and their relaxant effects on isolated rabbit corpus cavernosum investigated. Compounds Y-16 and Y-21 can alter ... -
Relaxation effects of adrenomedullin in carbachol-precontracted rabbit internal anal sphincter
Koyuncu, A; Yildirim, S; Aydin, C; Bagcivan, I; Sarac, B (SPRINGER-VERLAG TOKYO, 2003)Background The internal anal sphincter is a specialized continuation of the circular smooth muscle layer of the rectum. It has been found that internal anal sphincter tonus is significantly increased in the majority of ...