Browsing by Author "Bagcivan, Ihsan"
Now showing items 21-40 of 43
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Evaluation of urinary bladder function after acute spinal cord injury: an experimental study
Oztemur, Zekeriya; Tezeren, Guenduez; Bagcivan, Ihsan; Sarac, Buelent; Durmus, Nedim; Egilmez, Reyhan (TURKISH JOINT DISEASES FOUNDATION, 2010)Objectives: The aim of this study was to evaluate the efficacy of early surgical decompression of acute spinal cord injury through the evaluation of urinary bladder function in rabbits. Materials and methods: The study was ... -
In vitro evaluation of nebivolol effects on nonadrenergic noncholinergic responses in rabbit corpus cavernosum
Aydin, Kaya; Gokcen, Kaan; Yildirim, Sahin; Bagcivan, Ihsan; Parlak, Mesut; Gokce, Goekhan (WILEY, 2018)The purpose of this study was to compare the effects of nebivolol on nonadrenergic noncholinergic (NANC) relaxation functions that are mediated by electric field stimulation (EFS) in rabbit corpus cavernosum smooth muscle ... -
Ineffective Doses of Dexmedetomidine Potentiates the Antinociception Induced by Morphine and Fentanyl in Acute Pain Model
Unal, Mumin; Gursoy, Sinan; Altun, Ahmet; Duger, Cevdet; Kol, Iclal Ozdemir; Kaygusuz, Kenan; Bagcivan, Ihsan; Mimaroglu, Caner (KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, 2013)The aim of this study was to evaluate the synergistic potentiation effect of ineffective doses of dexmedetomidine on antinociception induced by morphine and fentanyl in acute pain model in rats. Seventy albino Wistar rats ... -
Investigating the effects of the Rho-kinase enzyme inhibitors AS1892802 and fasudil hydrochloride on the contractions of isolated pregnant rat myometrium
Ergul, Merve; Turgut, Nergiz H.; Sarac, Bulent; Altun, Ahmet; Yildirim, Sahin; Bagcivan, Ihsan (ELSEVIER SCIENCE BV, 2016)Objectives: Rho-kinases (ROCKs), are one of the dynamic structures of the actin cytoskeleton and they mediate different biological processes, including regulation of calcium sensitivity of smooth muscle contraction. The ... -
Investigation of acute effects of aflatoxin on rat proximal and distal colon spontaneous contractions
Gursoy, Nevcihan; Durmus, Nedim; Bagcivan, Ihsan; Sarac, Bulent; Parlak, Ahmet; Yildirim, Sahin; Kaya, Tijen (PERGAMON-ELSEVIER SCIENCE LTD, 2008)Aflatoxins are one of the most potent toxic, mutagenic, teratogenic, cancerogenic, and immunosuppresive substances that naturally Occurring contaminants of food. There are some studies in various animal species that have ... -
Investigation of Relaxant Effects of New Agents Affecting Nitric Oxide/Cyclic Guanosine Monophosphate Pathway on Sheep Oddi Sphincter
Sarac, Bulent; Durmus, Nedim; Bagcivan, Ihsan; Altun, Ahmet; Turan, Mustafa; Sencan, Mehmet (LIPPINCOTT WILLIAMS & WILKINS, 2010)Objectives: Nitric oxide (NO) is a potent nonadrenergic, noncholinergic mediator of gastrointestinal smooth muscle. We aimed to investigate the effects of new NO/cyclic guanosine monophosphate (cGMP) pathway-affecting ... -
Investigation of relaxant effects of propofol on sheep sphincter of Oddi
Bagcivan, Ihsan; Gursoy, Sinan; Yildirim, M. Kemal; Temiz, Tijen Kaya; Yildirim, Sahin; Yilmaz, Abdulkerim; Turan, Mustafa (KARGER, 2007)Background/Aims: Intravenous anesthetics are often used for conscious sedation in endoscopic retrograde cholangio-pancreatography ( ERCP) and endoscopic sphincter of Oddi ( SO) manometry. This study was designed to investigate ... -
Investigation of the Cardiac Effects of Pancuronium, Rocuronium, Vecuronium, and Mivacurium on the Isolated Rat Atrium
Gursoy, Sinan; Bagcivan, Ihsan; Durmus, Nedim; Kaygusuz, Kenan; Kol, Iclal Ozdemir; Duger, Cevdet; Yildirim, Sahin; Mimaroglu, Caner (ELSEVIER SCIENCE INC, 2011)BACKGROUND: Pancuronium, vecuronium, rocuronium, and mivacurium are nondepolarizing neuromuscular blocking agents that affect the cardiovascular system with different potencies. Their cardiovascular effects are clinically ... -
Investigation of the Relaxant Effect Mechanism of Ketamine on Normal and Ovalbumin-Induced Trachea in Guinea Pigs
Sarac, Bulent; Altun, Ahmet; Yildirim, Sahin; Yildirim, Mustafa Kemal; Temiz, Tijen Kaya; Bagcivan, Ihsan; Sencan, Mehmet (ORTADOGU AD PRES & PUBL CO, 2011)Objective: The aim of this study was to investigate of effects and the possible mechanisms of effects of ketamine on the isolated trachea preparations from control and ovalbumin sensitized guinea pigs. Material and Methods: ... -
Investigation of the relaxant effects of pancuronium, rocuronium, vecuronium and mivacurium on rat thoracic aorta
Gursoy, Sinan; Bagcivan, Ihsan; Durmus, Nedim; Kaygusuz, Kenan; Kol, Iclal Ozdemir; Yildirim, Sahin; Mimaroglu, Caner (LIPPINCOTT WILLIAMS & WILKINS, 2009)Background and objective Pancuronium, vecuronium, mivacurium and rocuronium are nondepolarizing neuromuscular blocking agents, which are competitive antagonists against acetylcholine at nicotinic receptors, and considered ... -
Investigation of the relaxant effects of pinacidil and Cromakalim on the sheep sphincter of Oddi
Bagcivan, Ihsan; Kaya, Tijen; Yildirim, M. Kemal; Turan, Mustafa (KARGER, 2006)Background/Aims: ATP-sensitive K+ (KATP) channels play an important role in the regulation of smooth muscle membrane potential. This study was designed to investigate the effects of pinacidil and cromakalim, KATP-sensitive ... -
Investigation of the role of the NO-cGMP pathway on YC-1 and DEA/NO effects on thoracic aorta smooth muscle responses in a rat preeclampsia model
Turgut, Nergiz Hacer; Temiz, Tijen Kaya; Turgut, Bulent; Karadas, Baris; Parlak, Mesut; Bagcivan, Ihsan (CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS, 2013)The present study was designed to investigate the effects of YC-1, a nitric oxide (NO)-independent soluble guanylate cyclase (sGC) activator, and DEA/NO, a NO donor, on smooth muscle responses in the preeclampsia model ... -
Investigation of the vasorelaxant effects of 3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole (YC-1) and diethylamine/nitric oxide (DEA/NO) on the human radial artery used as coronary bypass graft
Berkan, Ocal; Bagcivan, Ihsan; Kaya, Tijen; Yildirim, Kemal; Yildirim, Sahin; Dogan, Kasim (NATL RESEARCH COUNCIL CANADA-N R C RESEARCH PRESS, 2007)The radial artery (RA) is used as a spastic coronary bypass graft. This study was designed to investigate the mechanism of vasorelaxant effects of YC-1 (3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole), a nitric oxide ... -
Investigation of the vasorelaxant effects of moxonidine and its relaxation mechanism on the human radial artery when used as a coronary bypass graft
Sarac, Bulent; Korkmaz, Ozge; Altun, Ahmet; Bagcivan, Ihsan; Goksel, Sabahattin; Yildirim, Sahin; Berkan, Ocal (OXFORD UNIV PRESS, 2015)In both low- and high-risk patients undergoing coronary artery bypass grafting, the internal mammary artery is the first choice of arterial graft, and the second choice is the radial artery (RA). Unfortunately, RA spasms ... -
Labetalol, nebivolol, and propranolol relax human radial artery used as coronary bypass graft
Korkmaz, Ozge; Sarac, Bulent; Goksel, Sabahattin; Yildirim, Sahin; Berkan, Ocal; Bagcivan, Ihsan (MOSBY-ELSEVIER, 2015)Objective: Beta-blockers are a heterogeneous class of agents that are used in the treatment of many cardiovascular diseases, especially hypertension and atherosclerosis, and that are commonly prescribed after cardiac ... -
Lack of nitrate tolerance in isosorbid dinitrate- and sodium nitroprusside-induced relaxation of rabbit internal anal sphincter
Koyuncu, Ayhan; Bagcivan, Ihsan; Sarac, Bulent; Aydin, Cengiz; Yildirim, Sahin; Sarioglu, Yusuf (BAISHIDENG PUBL GRP CO LTD, 2008)AIM: To investigate the tolerance development against the relaxant effect of nitric oxide donating drug isosorbide dinitrate (ISDN) and sodium nitropruside (SNP) in internal anal sphincter (IAS) smooth muscle. METHODS: ... -
Mechanism of relaxation induced by nicotine in normal and ovalbumin-sensitized guinea-pig trachea
Cevit, Omer; Bagcivan, Ihsan; Sarac, Bulent; Parlak, Ahmet; Durmus, Nedim; Kava, Tiien (ELSEVIER SCIENCE BV, 2007)Nicotine is an irritant molecule in the cigarette that contributes airway hyper-reactivity. The aim of this study was to investigate the mechanism of these effects and effects of nicotine on the isolated trachea preparations ... -
Nifedipine Enhances the Relaxant Effects of Cyclo-Oxygenase Inhibitors on the Bovine Ciliary Muscle
Toker, Mustafa; Bagcivan, Ihsan; Topalkara, Aysen; Karadas, Baris; Durmus, Nedim; Parlak, Ahmet; Kaya, Tijen (MARY ANN LIEBERT, INC, 2008)Background/Aims: The inhibition of cyclo-oxygenase (COX) enzymes and the blockade of Ca2+ channels play an important role in the regulation of smooth muscle relaxation. This study was designed to investigate the relaxant ... -
The nitric oxide-cGMP signaling pathway plays a significant role in tolerance to the analgesic effect of morphine
Ozdemir, Ercan; Bagcivan, Ihsan; Durmus, Nedim; Altun, Ahmet; Gursoy, Sinan (CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS, 2011)Although the phenomenon of opioid tolerance has been widely investigated, neither opioid nor nonopioid mechanisms are completely understood. The aim of the present study was to investigate the role of the nitric oxide ... -
Rho-kinase inhibitors Y-27632 and fasudil prevent agonist-induced vasospasm in human radial artery
Disli, Olcay Murat; Ozdemir, Ercan; Berkan, Ocal; Bagcivan, Ihsan; Durmus, Nedim; Parlak, Ahmet (CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS, 2009)Radial artery (RA) vasospasm remains a potential cause of early graft failure after coronary artery bypass graft surgery, despite pretreatment with alpha-adrenergic or calcium channel blockers. Our aim was to investigate ...