Browsing by Author "Cevik, Ozge"
Now showing items 21-32 of 32
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N-acetylcysteine leads to greater ovarian protection than enoxaparin sodium in a rat ovarian torsion model
Ersoy, Gulcin Sahin; Eken, Meryem; Tal, Reshef; Oztekin, Deniz; Devranoglu, Belgin; Kaygusuz, Ecmel Isik; Cevik, Ozge (ELSEVIER SCI LTD, 2016)This study evaluated the effects of N-acetylcysteine (NAC) and enoxaparin on ovarian tissue preservation, ovarian reserve and oxidative damage following ovarian torsion/detorsion injury. Rats were divided into four groups ... -
Novel adipokines WISP1 and betatrophin in PCOS: relationship to AMH levels, atherogenic and metabolic profile
Ersoy, Gulcin Sahin; Ensari, Tugba Altun; Vatansever, Dogan; Emirdar, Volkan; Cevik, Ozge (TAYLOR & FRANCIS LTD, 2017)Objective: To determine the levels of WISP1 and betatrophin in normal weight and obese women with polycystic ovary syndrome (PCOS) and to assess their relationship with anti-Mullerian hormone (AMH) levels, atherogenic ... -
Platelets Proteomic Profiles of Acute Ischemic Stroke Patients
Cevik, Ozge; Baykal, Ahmet Tarik; Sener, Azize (PUBLIC LIBRARY SCIENCE, 2016)Platelets play a crucial role in the pathogenesis of stroke and antiplatelet agents exist for its treatment and prevention. Through the use of LC-MS based protein expression profiling, platelets from stroke patients were ... -
The preventive and curative effects of melatonin against abdominal aortic aneurysm in rats
Tekin, Gozde; Isbir, Selim; Sener, Goksel; Cevik, Ozge; Cetinel, Sule; Dericioglu, Okan; Arsan, Sinan; Cobanoglu, Adnan (MOSBY-ELSEVIER, 2018)Objective: Oxygen free radicals are important components involved in the histopathologic tissue alterations observed during abdominal aortic aneurysms (AAAs). This study examined whether melatonin has protective or therapeutic ... -
Protective effect of platelet-rich plasma on urethral injury model of male rats
Tavukcu, Hasan H.; Aytac, Omer; Atug, Fatih; Alev, Burcin; Cevik, Ozge; Bulbul, Nurdan; Yarat, Aysen; Cetinel, Sule; Sener, Goksel; Kulaksizoglu, Haluk (WILEY, 2018)Aims: Urethral stricture (US) formation is caused by fibrosis after excessive collagen formation following an injury or trauma to the urethra. In this study, we aimed to evaluate the effects of platelet-rich plasma (PRP) ... -
Resveratrol treatment may preserve the erectile function after radiotherapy by restoring antioxidant defence mechanisms, SIRT1 and NOS protein expressions
Sener, Tarik Emre; Tavukcu, Hasan Huseyin; Atasoy, Beste Melek; Cevik, Ozge; Kaya, Ozlem Tugce; Cetinel, Sule; Degerli, Ayse Dagli; Tinay, Ilker; Simsek, Ferruh; Akbal, Cem; Buttice, Salvatore; Sener, Goksel (NATURE PUBLISHING GROUP, 2018)Radiotherapy (RT) for prostate cancer (PC) can cause erectile dysfunction (ED) by damaging neurovascular structures with oxidative stress. In this study, we evaluated the effects of resveratrol, an antioxidant, on post-RT ... -
Riboflavin Treatment Reduces Apoptosis and Oxidative DNA Damage in a Rat Spinal Cord Injury Model
Sakarcan, Sinem; Ersahin, Mehmet; Eminoglu, Mehmet Emin; Cevik, Ozge; Ak, Esin; Ercan, Feriha; Sener, Goksel (AVES PRESS LTD, 2017)Objective: Spinal cord injury (SCI) leads to an inflammatory response and results in oxidative stress, which has deleterious effects on several organ systems. Riboflavin is an easily absorbed micronutrient that plays an ... -
Synthesis and Characterization of Celecoxib Derivatives as Possible Anti-Inflammatory, Analgesic, Antioxidant, Anticancer and Anti-HCV Agents
Kucukguzel, S. Guniz; Coskun, Inci; Aydin, Sevil; Aktay, Goknur; Gursoy, Sule; Cevik, Ozge; Ozakpinar, Ozlem Bingol; Ozsavci, Derya; Sener, Azize; Kaushik-Basu, Neerja; Basu, Amartya; Talele, Tanaji T. (MDPI, 2013)A series of novel N-(3-substituted aryl/alkyl-4-oxo-1,3-thiazolidin-2-ylidene)-4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl] benzenesulfonamides 2a-e were synthesized by the addition of ethyl alpha-bromoacetate ... -
Synthesis of Diflunisal Thiazolidinones as Anticancer Agents
Senkardes, Sevil; Ozakpinar, Ozlem B.; Ozsavci, Derya; Sener, Azize; Cevik, Ozge; Kucukguzel, S. Guniz (BENTHAM SCIENCE PUBL LTD, 2016)A series of diflunisal 4-thiazolidinones were synthesized. Some selected compounds were determined at one dose towards the full panel of 60 human cancer cell lines by National Cancer Institute. 2',4'-Difluoro-4-hydroxy-N ... -
Synthesis, Cytotoxicity, and Pro-Apoptosis Activity of Etodolac Hydrazide Derivatives as Anticancer Agents
Cikla, Pelin; Ozsavci, Derya; Bingol-Ozakpinar, Ozlem; Sener, Azize; Cevik, Ozge; Ozbas-Turan, Suna; Akbuga, Julide; Sahin, Fikrettin; Kucukguzel, S. Guniz (WILEY-V C H VERLAG GMBH, 2013)Etodolac hydrazide and a novel series of etodolac hydrazide-hydrazones 315 and etodolac 4-thiazolidinones 1626 were synthesized in this study. The structures of the new compounds were determined by spectral (FT-IR, 1H NMR, ... -
Tumor necrosis factor-alpha induced caspase-3 activation-related iNOS gene expression in ADP-activated platelets
Cevik, Ozge; Adiguzel, Zelal; Baykal, Ahmet Tarik; Sener, Azize (TUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEY, 2017)Platelets are sensitive cells and are easily activated by different stimulants in the circulation system. It is known that tumor necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine and plays a role in inflammation. ... -
WISP1 is a novel adipokine linked to metabolic parameters in gestational diabetes mellitus
Ersoy, Gulcin Sahin; Ensari, Tugba Altun; Subas, Seda; Giray, Burak; Simsek, Engin Ersin; Cevik, Ozge (TAYLOR & FRANCIS LTD, 2017)Objective: To investigate Wnt1-inducible signaling pathway protein-1 (WISP1) levels and their correlation with metabolic parameters in pregnant women with gestational diabetes mellitus (GDM) and non-GDM healthy pregnant ...