Browsing by Author "Ozdemir, Ozturk"
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The effect of 3-methylcholanthrene and butylated hydroxytoluene on glycogen levels of liver, muscle, testis, and tumor tissues of rats
Polat, Fikriye; Dere, Egemen; Gul, Eylem; Yelkuvan, Izzet; Ozdemir, Ozturk; Bingol, Gunsel (TUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEY, 2013)This study examined the effects of separate and combined applications of 3-methylcholanthrene, a polycyclic aromatic hydrocarbon and potent carcinogenic agent, and butylated hydroxytoluene, the antioxidant food additive, ... -
Effects of the Chemokine Receptor 5 (CCR5)-Delta32 Mutation on Hepatitis C Virus-Specific Immune Responses and Liver Tissue Pathology in HCV Infected Patients
Yilmaz, Abdulkerim; Alagozlu, Hakan; Ozdemir, Ozturk; Arici, Sema (KOWSAR PUBL, 2014)Background: The specific antiviral T cells provide CC chemokine receptor 5 (CCR5) for the immune response during the hepatitis C virus (HCV) infection. Heterogenous and/or homozygous 32 base pair deletion in CCR5 gene (CCR5 ... -
eNOS G894T Polymorphism and Abdominal Aortic Aneurysms
Atli, Fahri Hayri; Manduz, Sinasi; Katrancioglu, Nurkay; Ozum, Unal; Disli, Olcay Murat; Atahan, Erhan; Ozdemir, Ozturk; Dogan, Kasim; Berkan, Ocal (SAGE PUBLICATIONS INC, 2010)Background: The genetic risk factors that contribute to the risk of developing abdominal aortic aneurysm ( AAA) are poorly understood. We assessed the association of endothelial nitric oxide synthase ( eNOS) gene polymorphism ... -
Evaluation of the cell death pathway and apoptosis-stunning effect relationship after low- and high-dose I-131 administrations in rat thyroid tissue
Turgut, Bulent; Babul, Aydan; Ozdemir, Ozturk; Erselcan, Taner (MARY ANN LIEBERT INC, 2006)Objectives: This study had two aims; (1) to describe the cell death pathway (apoptosis or necrosis) induced by a low and high dose of radioiodine (I-131) in rat thyroid tissue in in vivo conditions and (2) to determine the ... -
Evaluation of the p53 tumor suppressor gene mutation in normal rat salivary gland tissue after radioiodine application: An experimental study
Turgut, Bulent; Ozdemir, Ozturk; Erselcan, Taner (HEALTH COMMUNICATIONS INC, 2006)In this experimental study, investigators explored p53 tumor suppressor gene mutation induced by low and high doses of iodine-131 sodium iodide (I-131) in salivary gland tissue in rats. Group 1 consisted of 10 rats; low ... -
A Frame-Shift Mutation in the SLC34A2 Gene in Three Patients with Pulmonary Alveolar Microlithiasis in an Inbred Family
Dogan, Omer Tamer; Ozsahin, Sefa Levent; Gul, Eylem; Arslan, Sulhattin; Koksal, Binnur; Berk, Serdar; Ozdemir, Ozturk; Akkurt, Ibrahim (JAPAN SOC INTERNAL MEDICINE, 2010)Pulmonary alveolar microlithiasis (PAM) is a rare disease characterized by the presence of small calculi in the alveolar space. The SLC34A2 is thought to be responsible for the disease. We encountered three siblings of an ... -
Germ-line MTHFR C677T, FV H1299R and PAI-1 5G/4G Variations in Breast Carcinoma
Ozen, Filiz; Erdis, Eda; Sik, Ebru; Silan, Fatma; Uludag, Ahmet; Ozdemir, Ozturk (ASIAN PACIFIC ORGANIZATION CANCER PREVENTION, 2013)Background: Various oncogenes related to cancer have been extensively studied and several polymorphisms have been found to be associated with breast cancer. The current report outlines analysis of germ-line polymorphisms ... -
Heterozygous Deletion of Exon 8 in WFS1 Gene in Two Wolfram Syndrome Probands with Hearing Loss: Case Report
Altuntas, Emine Elif; Ozdemir, Ozturk; Bora, Adem; Koksal, Binnur; Kurtulgan, Hande Kucuk; Muderris, Suphi (ORTADOGU AD PRES & PUBL CO, 2011)Point mutations in the Wolfram syndrome 1 gene (WFS1) are attributed the autosomal dominant and/or recessive mild type sensorineural hearing loss in first degree relatives. Total genomic DNA was isolated from peripheral ... -
In vivo evaluation of the genotoxic effects of clomiphene citrate on rat reticulocytes: A micronucleus genotoxicity
Duran, Bulent; Ozdemir, Ismail; Demirel, Yeltekin; Ozdemir, Ozturk; Cetin, Ali; Guven, Aysel (KARGER, 2006)Objective: To determine the genotoxic effects of clomiphene citrate (CC) on rat reticulocytes in vivo. Methods: In this prospective, randomized, controlled study, rats were each assigned randomly to the CC 50, CC 100, CC ... -
Increased T-Allele Frequency of 677 C > T Polymorphism in the Methylenetetrahydrofolate Reductase Gene in Differentiated Thyroid Carcinoma
Ozdemir, Semra; Silan, Fatma; Hasbek, Zekiye; Uludag, Ahmet; Atik, Sinem; Erselcan, Taner; Ozdemir, Ozturk (MARY ANN LIEBERT INC, 2012)Background: Epigenetic alterations in the global DNA methylation status may be associated with an increased risk of some cancer types in humans. The methylenetetrahydrofolate reductase (MTHFR) gene is involved in folic ... -
KRAS, BRAF oncogene mutations and tissue specific promoter hypermethylation of tumor suppressor SFRP2, DAPK1, MGMT, HIC1 and p16 genes in colorectal cancer patients
Bagci, Binnur; Sari, Musa; Karadayi, Kursat; Turan, Mustafa; Ozdemir, Ozturk; Bagci, Gokhan (IOS PRESS, 2016)BACKGROUND: Colorectal cancer is a serious disease that causes significant morbidity and mortality in developed countries. Genetic changes, such as mutations in proto-oncogenes and DNA repair genes, and loss of function ... -
Methylenetetrahydrofolate Reductase Gene Germ-Line C677T and A1298C SNPs are Associated with Colorectal Cancer Risk in the Turkish Population
Ozen, Filiz; Sen, Metin; Ozdemir, Ozturk (ASIAN PACIFIC ORGANIZATION CANCER PREVENTION, 2014)Colorectal cancer (CRC) is the third most common cause of death due to cancer in the worldwide and the incidence is also increasing in Turkey. Our present aim was to investigate any association between germ-line ... -
Micronucleus frequencies in groups receiving external or internal radiation
Ozdal, Aysegul; Erselcan, Taner; Ozdemir, Ozturk; Silov, Guler; Erdogan, Zeynep; Turhal, Ozgul (MEDKNOW PUBLICATIONS & MEDIA PVT LTD, 2016)Objective: In the current study, we aimed to explore whether there is alteration between pre-and post-treatment micronucleus (MN) frequencies induced by internal and external ionizing radiation. Materials and Methods: The ... -
Multiple Inherited Thrombophilic Gene Polymorphisms in Spontaneous Abortions in Turkish Population
Yalcintepe, Sinem; Ozdemir, Ozturk; Hacivelioglu, Servet Ozden; Akurut, Cisem; Koc, Evrim; Uludag, Ahmet; Cosar, Emine; Silan, Fatma (CELLULAR & MOLECULAR BIOLOGY RESEARCH CENTER, 2015)The aim of this study was to investigate the possible role of multiple inherited thrombophilic gene variations in women with unexplained spontaneous abortions. For this purpose, the Factor V Leiden (FVL) (rs6025), Prothrombin ... -
Possible Roles of the Xenobiotic Transporter P-glycoproteins Encoded by the MDR1 3435 C > T Gene Polymorphism in Differentiated Thyroid Cancers
Ozdemir, Semra; Uludag, Ahmet; Silan, Fatma; Atik, Sinem Yalcintepe; Turgut, Bulent; Ozdemir, Ozturk (ASIAN PACIFIC ORGANIZATION CANCER PREVENTION, 2013)Background: P-glycoprotein (Pgp), encoded by the multidrug resistance 1 (MDR1) gene, is an efflux transporter which plays an important role in pharmacokinetics. The current preliminary study was designed to determine ... -
Predictive significance of KRAS point mutation in patients with non-small cell lung carcinoma relation to smoking and asbestos exposure in middle Anatolia population
Arslan, Sulhattin; Akkurt, Ibrahim; Koksal, Binnur; Karadayi, Sule; Ozdemir, Ozturk (DRUNPP-SARAJEVO, 2010)Persons who have been occupationally exposed to environmental mutagens have a substantially increased risk for somatic oncogene mutations. Structural mutation in viral kristen rat sarcoma oncogene homolog 2 (KRAS; v-Ki-ras ... -
The Presence of PAI-1 4G/5G and ACE DD Genotypes Increases the Risk of Early-Stage AVF Thrombosis in Hemodialysis Patients
Gungor, Yahya; Kayatas, Mansur; Yildiz, Gursel; Ozdemir, Ozturk; Candan, Ferhan (TAYLOR & FRANCIS LTD, 2011)Background: In this study, we investigated the relationship between early arteriovenous fistula (AVF) thrombosis with angiotensin-converting enzyme (ACE) gene and thrombophilic factor gene polymorphisms. Methods: Thirty-five ... -
Prevalence of known mutations in the MEFV gene in a population screening with high rate of carriers
Ozdemir, Ozturk; Sezgin, Ilhan; Kurtulgan, Hande Kucuk; Candan, Ferhan; Koksal, Binnur; Sumer, Haldun; Icagasioglu, Dilara; Uslu, Atilla; Yildiz, Fazilet; Arslan, Sulhattin; Cetinkaya, Selma; Citli, Senol; Oztemur, Zekeriya; Kayatas, Mansur (SPRINGER, 2011)The Familial Mediterranean Fever (FMF) shows an autosomal recessive pattern of inheritance and affects certain ethnic groups. Disease is caused by mutations in MEFV gene and more than 180 mutations have been defined in ...