Browsing by Author "Karadas, Baris"
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Additive interaction of intraperitoneal dexmedetomidine and topical nimesulide, celecoxib, and DFU for antinociception
Karadas, Baris; Kaya, Tijen; Gulturk, Sefa; Parlak, Ahmet; Gursoy, Sinan; Cetin, Ali; Bagcivan, Ihsan (ELSEVIER SCIENCE BV, 2007)Nimesulide, celecoxib, and DFU (5, 5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulphonyl)phenyl-2(5H)-furanone) are nonsteroidal antiinflammatory drugs (NSAIDs) with selective cyclo-oxygenase (COX)-2 blocking properties and ... -
Alterations in spontaneous contractions of rat ileum and jejunum after peritonitis
Koyluogu, Gokhan; Bageivan, Ihsan; Karadas, Baris; Guney, Cengiz; Durmus, Nedim; Altun, Ahmet; Kaya, Tijen (ELSEVIER SCIENCE BV, 2008)The aim of this study was to investigate the effects of peritonitis on spontaneous contractions of ileum and jejunum smooth muscles isolated from rats. Peritonitis was induced by cecal ligation and puncture in 8 rats. ... -
Comparative relaxant effects of YC-1 and DEA/NO on the sheep sphincter of Oddi
Bagcivan, Ihsan; Kaya, Tijen; Turan, Mustafa; Karadas, Baris; Sarac, Buelent; Duman, Mustafa (KARGER, 2006)Background/Aims: Nitric oxide (NO) is a major inhibitor in various parts of the gastrointestinal tract. This study was designed to compare the effects of YC-1, NO-independent soluble guanylate cyclase (sGC) activator, and ... -
Do antibiotics contribute to postoperative ileus? Contractile responses of ileum smooth muscle in guinea pigs to long-term parenteral ceftriaxone and ampicillin
Ceran, Canan; Karadas, Baris; Kaya, Tijen; Arpacik, Mehmet; Bagcivan, Ihsan; Sarac, Buelent (BLACKWELL PUBLISHING, 2006)Background: Antibiotics may impair small bowel smooth muscle contractility and contribute to postoperative ileus. The aim of this study was to compare the contractile responses of ileum smooth muscle to different agonists ... -
The effect of sildenafil on the altered thoracic aorta smooth muscle responses in rat pre-eclampsia model
Turgut, Nergiz Hacer; Temiz, Tijen Kaya; Bagcivan, Ihsan; Turgut, Butent; Gulturk, Sefa; Karadas, Baris (ELSEVIER SCIENCE BV, 2008)The pathophysiology of pre-eclampsia is still unknown thus effective primary prevention is not possible at the stage. The present study was conducted to research the smooth muscle responses in the pre-eclampsia model with ... -
Effects and Selectivity of CL 316243, Beta-3-Adrenoceptor Agonist, in Term-Pregnant Rat Myometrium
Kaya, Tijen; Karadas, Baris; Altun, Ahmet; Sarac, Ikram; Bagcivan, Ihsan (KARGER, 2012)Background/Aims: Recent evidence supports a predominant role of beta(3)-adrenoceptors at the end of pregnancy in myometrium. This study was designed to characterize the pharmacology of the selective beta(3)-adrenoceptor ... -
Effects of formoterol and BRL 37344 on human umbilical arteries in vitro in normotensive and pre-eclamptic pregnancy
Karadas, Baris; Kaya, Tijen; Cetin, Meral; Parlak, Ahmet; Durmus, Nedim; Bagcivan, Ihsan; Gulturk, Sefa (ELSEVIER SCIENCE INC, 2007)Alterations in vascular responses to beta-adrenoceptor agonists in normotensive pregnancy and pre-eclampsia are not fully understood. Thus, we studied changes in vasodilator responses to beta(2)-adrenoceptor agonist ... -
Investigation of the role of the NO-cGMP pathway on YC-1 and DEA/NO effects on thoracic aorta smooth muscle responses in a rat preeclampsia model
Turgut, Nergiz Hacer; Temiz, Tijen Kaya; Turgut, Bulent; Karadas, Baris; Parlak, Mesut; Bagcivan, Ihsan (CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS, 2013)The present study was designed to investigate the effects of YC-1, a nitric oxide (NO)-independent soluble guanylate cyclase (sGC) activator, and DEA/NO, a NO donor, on smooth muscle responses in the preeclampsia model ... -
Nifedipine Enhances the Relaxant Effects of Cyclo-Oxygenase Inhibitors on the Bovine Ciliary Muscle
Toker, Mustafa; Bagcivan, Ihsan; Topalkara, Aysen; Karadas, Baris; Durmus, Nedim; Parlak, Ahmet; Kaya, Tijen (MARY ANN LIEBERT, INC, 2008)Background/Aims: The inhibition of cyclo-oxygenase (COX) enzymes and the blockade of Ca2+ channels play an important role in the regulation of smooth muscle relaxation. This study was designed to investigate the relaxant ... -
Relaxant effects of beta-adrenoceptor agonist formoterol and BRL 37344 on bovine iris sphincter and ciliary muscle
Topalkara, Aysen; Karadas, Baris; Toker, Mustafa I.; Kaya, Tijen; Durmus, Nedim; Turgut, Bulent (ELSEVIER SCIENCE BV, 2006)We investigated the relaxant effect Of beta(2)-adrenoceptor agonist formoterol and beta(3)-adrenoceptor agonist BRL 37344 on bovine iris sphincter and ciliary muscle and measured CAMP and cGMP levels. his sphincter (n = ...
