Browsing by Author "Polat, Zubeyde Akin"
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Antiangiogenic activities of bemiparin sodium, enoxaparin sodium, nadroparin calcium and tinzaparin sodium
Dogan, Omer Tamer; Polat, Zubeyde Akin; Karahan, Oguz; Epozturk, Kursat; Altun, Ahmet; Akkurt, Ibrahim; Cetin, Ali (PERGAMON-ELSEVIER SCIENCE LTD, 2011)Introduction: The low-molecular-weight heparins have been demonstrated to have antiangiogenic effects in various assays. We aimed to demonstrate and compare the antiangiogenic effects of four types of commercially available ... -
The antiangiogenic effects of levosimendan in a CAM assay
Katrancioglu, Nurkay; Karahan, Oguz; Kilic, Ahmet Turhan; Altun, Ahmet; Katrancioglu, Ozgur; Polat, Zubeyde Akin (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2012)Background: There is a physiological balance between the stimulatory and inhibitory signals for blood vessel growth. In many symptomatic patients with peripheral artery disease, coronary artery disease, and ischemic chronic ... -
Clinical and histologic evaluations of experimental Acanthamoeba keratitis
Polat, Zubeyde Akin; Ozcelik, Semra; Vural, Ayse; Yildiz, Esin; Cetin, Ali (SPRINGER, 2007)Amoebic keratitis, a sight-threatening, progressive corneal disease, is commonly caused by ubiquitous, pathogenic, free-living Acanthamoeba spp., which are widely distributed in the environment. We investigated clinical ... -
Comparison of the antiangiogenic effects of heparin sodium, enoxaparin sodium, and tinzaparin sodium by using chorioallantoic membrane assay
Katrancioglu, Nurkay; Karahan, Oguz; Kilic, Ahmet Turhan; Altun, Ahmet; Katrancioglu, Ozgur; Polat, Zubeyde Akin (LIPPINCOTT WILLIAMS & WILKINS, 2012)Unfractionated heparin (UFH) and low molecular weight heparins have been used as anticoagulation agents in cardiovascular clinics for decades. However, these molecules also have potent antiangiogenic effects. Whereas, ... -
Cytotoxicity of three maleic anhydride copolymers and common solvents used for polymer solvation
Karakus, Gulderen; Zengin, Haci Bayram; Polat, Zubeyde Akin; Yenidunya, Ali Fazil; Aydin, Semiha (SPRINGER, 2013)Three maleic anhydride copolymers were synthesized by free-radical copolymerization. The synthesized products were named as follows: maleic anhydride-styrene (MAST); maleic anhydride-vinyl acetate (MAVA), and maleic ... -
Effect of combined chlorhexidine gluconate and Neosporin on experimental keratitis with two pathogenic strains of Acanthamoeba
Polat, Zubeyde Akin; Vural, Ayse (SPRINGER, 2012)Acanthamoeba keratitis (AK) is a painful, sight-threatening, and difficult-to-treat corneal infection caused by the ubiquitous free-living amoebae Acanthamoeba species. The aim of the present study was to compare the ... -
The effect of propolis in experimental Acanthamoeba keratitis
Vural, Ayse; Polat, Zubeyde Akin; Topalkara, Aysen; Toker, Mustafa Ilker; Erdogan, Haydar; Arici, Mustafa Kemal; Cetin, Ali (WILEY, 2007)Purpose: To examine the effect of propolis in a rat model of Acanthamoeba keratitis and to determine its in vitro cytotoxicity in cultured corneal epithelial cells. Methods: Eighteen Wistar albino rats were used. Cultured ... -
Effect of propolis on survival of periodontal ligament cells: New storage media for avulsed teeth
Ozan, Fatih; Polat, Zubeyde Akin; Er, Kursat; Ozan, Ulku; Deger, Orhan (ELSEVIER SCIENCE INC, 2007)Propolis is a multifunctional material used by bees in the construction and maintenance of their hives. Propolis possesses several biologic activities such as anti-inflammatory, antibacterial, antioxidant, antifungal, ... -
Effects of low molecular weight heparins and unfractionated heparin on viability of human umbilical vein endothelial cells
Guler, Tolga; Polat, Zubeyde Akin; Yayci, Eyup; Atacag, Tijen; Cetin, Ali (SPRINGER HEIDELBERG, 2013)The aim of this study was to investigate the effects of bemiparin, nadroparin, enoxaparin, and heparin on viability of human umbilical vein endothelial cells (HUVEC). Cultivation of HUVEC was performed in an incubator ... -
Effects of tyrosine kinase inhibitor E7080 and eNOS inhibitor L-NIO on colorectal cancer alone and in combination
Altun, Ahmet; Temiz, Tijen Kaya; Balci, Ezgi; Polat, Zubeyde Akin; Turan, Mustafa (SPRINGER, 2013)Objective: To investigate the effects of E7080 and N-5-(1-iminoethyl)-L-ornithine dihydrochloride (L-NIO) on colorectal cancer alone and in combination. Methods: HT29 colorectal cancer cell line from Sap Institute was used. ... -
Efficacy of contact lens storage solutions against trophozoite and cyst of Acanthamoeba castellanii strain 1BU and their cytotoxic potential on corneal cells
Polat, Zubeyde Akin; Vural, Ayse; Cetin, Ali (SPRINGER, 2007)Acanthamoeba is a free-living amoeba causing a potentially blinding infection of the cornea. Contact lens wearers are most at risk and account for about 95% of cases. We investigated the in vitro effectiveness of 10 contact ... -
Efficacy of miltefosine for topical treatment of Acanthamoeba keratitis in Syrian hamsters
Polat, Zubeyde Akin; Obwaller, Andreas; Vural, Ayse; Walochnik, Julia (SPRINGER, 2012)Acanthamoeba keratitis is a painful corneal infection and difficult to treat because no sufficiently efficient drug has yet been available. The aim of the study therefore was to assess the therapeutic potential of miltefosine ... -
Evaluation of the Cytotoxic effects of various monomers In vitro also their effects on Apoptosis and GFAP immunolocalization in rat spinal cord In vivo
Saraydin, Serpil Unver; Bulut, H. Eray; Ozum, Unal; Inan, Z. Deniz Sahin; Polat, Zubeyde Akin; Yalman, Yucel; Saraydin, Dursun (DRUNPP-SARAJEVO, 2011)Biomaterials are mostly polymers made by monomers, and are used in artificial organ production in contemporary medicine. They are prepared by the polimerization reaction of certain monomers. The aim of the present study ... -
Evaluation of the in vitro activity of ceragenins against Trichomonas vaginalis
Polat, Zubeyde Akin; Cetin, Ali; Savage, Paul B. (WALTER DE GRUYTER GMBH, 2016)Trichomonosis, caused by the protozoan parasite Trichomonas vaginalis, is a curable sexually transmitted disease that is most commonly encountered worldwide. Increasing importance of trichomoniasis and emerging of resistance ... -
In Vitro Amoebicidal Activity of a Ceragenin, Cationic Steroid Antibiotic-13, Against Acanthamoeba castellanii and Its Cytotoxic Potential
Polat, Zubeyde Akin; Savage, Paul B.; Genberg, Carl (MARY ANN LIEBERT INC, 2011)Acanthamoeba is a free-living amoeba causing a potentially blinding infection of the cornea. Acanthamoeba keratitis is difficult to treat, without total efficacy in some patients because of cysts that are less susceptible ... -
In Vitro Amoebicidal Activity of Salvia staminea and Salvia caespitosa on Acanthamoeba castellanii and Their Cytotoxic Potentials on Corneal Cells
Goze, Ismihan; Alim, Ahmet; Dag, Seker; Tepe, Bektas; Polat, Zubeyde Akin (MARY ANN LIEBERT, INC, 2009)Background/Aims: Amoebic keratitis is difficult to treat with total efficacy in some patients because of cysts, which are less susceptible than trophozoites to the usual treatments. We investigated the in vitro effectiveness ... -
In Vitro Comparison of the Cytotoxicity and Water Sorption of Two Different Denture Base Systems
Akin, Hakan; Tugut, Faik; Polat, Zubeyde Akin (WILEY-BLACKWELL, 2015)PurposeDenture base resins have the potential to cause cytotoxicity in vivo, and the mechanical properties of resins are affected by water sorption. There is a correlation between residual monomer and water sorption. Thus, ... -
In vitro effectiveness of Thymus sipyleus subsp sipyleus var. sipyleus on Acanthamoeba castellanii and its cytotoxic potential on corneal cells
Polat, Zubeyde Akin; Tepe, Bektas; Vural, Ayse (SPRINGER, 2007)Acanthamoeba species are an important cause of microbial keratitis that may cause severe ocular inflammation and visual loss. Acanthamoeba keratitis is difficult to treat, without total efficacy in some patients because ... -
In vitro evaluation of the amoebicidal activity of garlic (Allium sativum) extract on Acanthamoeba castellanii and its cytotoxic potential on corneal cells
Polat, Zubeyde Akin; Vural, Ayse; Ozan, Fatih; Tepe, Bektas; Oezcelik, Semra; Cetin, Ali (MARY ANN LIEBERT, INC, 2008)Free-living protozoa of the genus Acanthamoeba can cause one of the most severe, potentially sight-threatening infections of the eye, the so-called A. keratitis. A. keratitis is difficult to treat because, under adverse ... -
Modification of Maleic Anhydride-Styrene Copolymer with Noradrenaline by Chemical and Enzymatic Methods
Karakus, Gulderen; Yenidunya, Ali Fazil; Zengin, Haci Bayram; Polat, Zubeyde Akin (WILEY-BLACKWELL, 2011)Maleic anhydride copolymer was modified with another biologically active agent, noradrenaline (NA), using both chemical and enzymatic methods. The modification and synthesized products were named as follows: chemical ...
