Browsing by Author "Taslimi, Parham"
Now showing items 1-15 of 15
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Aminopyrazole-substituted metallophthalocyanines: Preparation, aggregation behavior, and investigation of metabolic enzymes inhibition properties
Guzel, Emre; Kocyigit, Umit M.; Arslan, Baris S.; Atas, Mehmet; Taslimi, Parham; Gokalp, Faik; Nebioglu, Mehmet; Sisman, Ilkay; Gulcin, Ilhami (WILEY-V C H VERLAG GMBH, 2019)The synthesis, characterization, aggregation behavior, theoretical studies, and investigation of antimicrobial, antidiabetic, and anticholinergic properties of 4-(2-(5-amino-4-(4-bromophenyl)-3-methyl-1H-pyrazol-1-yl)eth ... -
Characterization and inhibition effects of some metal ions on carbonic anhydrase enzyme from Kangal Akkaraman sheep
Kocyigit, Umit M.; Taslimi, Parham; Gulcin, Ilhami (WILEY, 2018)In this work, the carbonic anhydrase (CA) enzyme was purified from Kangal Akkaraman sheep in Sivas, Turkey with specific activity value of 6681.57 EU/mg and yield of 14.90% with using affinity column chromatography. For ... -
The effects of wireless electromagnetic fields on the activities of carbonic anhydrase and acetylcholinesterase enzymes in various tissues of rats
Kocyigit, Umit Muhammet; Taslimi, Parham; Gurses, Fatih; Soylu, Sinan; Dastan, Sevgi Durna; Gulcin, Ilhami (WILEY, 2018)The purpose of our study is to assist in understanding the effects of wireless electromagnetic waves on carbonic anhydrase (CA) and acetylcholinesterase (AChE) enzymes activities in the different tissues of the rats. For ... -
Evaluation of acetylcholinesterase and carbonic anhydrase inhibition profiles of 1,2,3,4,6-pentasubstituted-4-hydroxy-cyclohexanes
Kocyigit, Umit M.; Taslimi, Parham; Gezegen, Hayreddin; Gulcin, Ilhami; Ceylan, Mustafa (WILEY, 2017)Carbonic anhydrase (CA; EC 4.2.1.1) is used for remedial purposes for several years, as there is significant focus on expanding more new activators (CAAs) and high affinity inhibitors. Alzheimers disease and other similar ... -
In vitro cytotoxic and in vivo antitumoral activities of some aminomethyl derivatives of 2,4-dihydro-3H-1,2,4-triazole-3-thiones-Evaluation of their acetylcholinesterase and carbonic anhydrase enzymes inhibition profiles
Timur, Irfan; Kocyigit, Umit M.; Dastan, Taner; Sandal, Suleyman; Ceribasi, Ali Osman; Taslimi, Parham; Gulcin, Ilhami; Koparir, Metin; Karatepe, Mustafa; Ciftci, Mehmet (WILEY, 2019)The 1,2,4-triazole and its derivatives were reported to exhibit various pharmacological activities such as antimicrobial, analgesic, anti-inflammatory, antitumoural, cytotoxic, and antioxidant properties. In this study, a ... -
Inhibitory effects of oxytocin and oxytocin receptor antagonist atosiban on the activities of carbonic anhydrase and acetylcholinesterase enzymes in the liver and kidney tissues of rats
Kocyigit, Umit M.; Taskiran, Ahmet Sevki; Taslimi, Parham; Yokus, Ahmet; Temel, Yusuf; Gulcin, Ilhami (WILEY, 2017)The aim of this study was to investigate the effects of oxytocin (OT), atosiban, which is an OT receptor antagonist, and OT-atosiban chemicals injected to rats on the activities of carbonic anhydrase (CA) and acetylcholinesterase ... -
Inhibitory effects of some drugs on carbonic anhydrase enzyme purified from Kangal Akkaraman sheep in Sivas, Turkey
Kocyigit, Umit M.; Dastan, Sevgi Durna; Taslimi, Parham; Dastan, Taner; Gulcin, Ilhami (WILEY, 2018)In this study, carbonic anhydrase (CA) enzyme was purified and characterized from blood samples of Kangal Akkaraman sheep and inhibitory properties on certain antibiotics were examined. CA purification was composed of ... -
Investigation of acetylcholinesterase and mammalian DNA topoisomerases, carbonic anhydrase inhibition profiles, and cytotoxic activity of novel bis(-aminoalkyl)phosphinic acid derivatives against human breast cancer
Dastan, Taner; Kocyigit, Umit M.; Dastan, Sevgi Durna; Kilickaya, Pakize Canturk; Taslimi, Parham; Cevik, Ozge; Koparir, Metin; Orek, Cahit; Gulcin, Ilhami; Cetin, Ahmet (WILEY, 2017)The aim of this study was to evaluate biologically active novel molecules having potentials to be drugs by their antitumor properties and by activities of apoptotic caspase and topoisomerase. Following syntheses of novel ... -
Synthesis and Carbonic Anhydrase Inhibition of Tetrabromo Chalcone Derivatives
Kocyigit, Umit M.; Budak, Yakup; Eliguzel, Fikret; Taslimi, Parham; Kilic, Deryanur; Gulcin, Ilhami; Ceylan, Mustafa (WILEY-V C H VERLAG GMBH, 2017)In the present study, human carbonic anhydrase (hCA) enzyme was purified and characterized from fresh blood human red cells by Sepharose-4B-l-tyrosine-sulfanilamide affinity gel chromatography. Secondly, a series of new ... -
Synthesis and investigation of antibacterial activities and carbonic anhydrase and acetyl cholinesterase inhibition profiles of novel 4,5-dihydropyrazol and pyrazolyl-thiazole derivatives containing methanoisoindol-1,3-dion unit
Budak, Yakup; Kocyigit, Umit M.; Gurdere, Meliha Burcu; Ozcan, Kezban; Taslimi, Parham; Gulcin, Ilhami; Ceylan, Mustafa (TAYLOR & FRANCIS INC, 2017)Novel 4,5-dihydropyrazole derivatives (3a-i), 3-(4-((3aR,4S,7R,7aS)-1,3-dioxo-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindol-2(3H)-yl)phenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-1-carbothio amide, were obtained by the addition ... -
Synthesis and investigation of anticancer, antibacterial activities and carbonic anhydrase, acetylcholinesterase inhibition profiles of novel (3aR,4S,7R,7aS)-2-[4-[1-acetyl-5-(aryl/heteroaryl)-4,5-dihydro-1H-pyrazol-3-yl]phenyl]-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-diones
Kocyigit, Umit M.; Budak, Yakup; Gurdere, Meliha Burcu; Duru, Nese; Taslimi, Parham; Gulcin, Ilhami; Ceylan, Mustafa (SPRINGER WIEN, 2019)A series of novel 1,3,5-trisubstituted pyrazoline derivatives, (3aR,4S,7R,7aS)-2-[4-[1-acetyl-5-(aryl/heteroaryl)-4,5-dihydro-1H-pyrazol-3-yl]phenyl]-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-diones, were ... -
Synthesis of chalcone-imide derivatives and investigation of their anticancer and antimicrobial activities, carbonic anhydrase and acetylcholinesterase enzymes inhibition profiles
Kocyigit, Umit Muhammet; Budak, Yakup; Gurdere, Meliha Burcu; Erturk, Fatih; Yencilek, Belkiz; Taslimi, Parham; Gulcin, Ilhami; Ceylan, Mustafa (TAYLOR & FRANCIS LTD, 2018)The new 1-(4-(3-(aryl)acryloyl)phenyl)-1H-pyrrole-2,5-diones (5a-g) were prepared from 4-aminchalcones (3a-g) and screened for biological activities. All compounds (3a-g and 5a-g), except 3d and 3e displayed good cytotoxic ... -
Synthesis of some novel pyridine compounds containing bis-1,2,4-triazole/thiosemicarbazide moiety and investigation of their antioxidant properties, carbonic anhydrase, and acetylcholinesterase enzymes inhibition profiles
Bulut, Nilufer; Kocyigit, Umit M.; Gecibesler, Ibrahim H.; Dastan, Taner; Karci, Huseyin; Taslimi, Parham; Dastan, Sevgi Durna; Gulcin, Ilhami; Cetin, Ahmet (WILEY, 2018)Some novel derivatives of thiosemicarbazide and 1,2,4-triazole-3-thiol were synthesized and evaluated for their biological activities. The title compounds were prepared starting from readily available pyridine-2,5-dicarboxylic ... -
Synthesis, characterization, and SAR of arylated indenoquinoline-based cholinesterase and carbonic anhydrase inhibitors
Ekiz, Makbule; Tutar, Ahmet; Okten, Salih; Butun, Burcu; Kocyigit, Umit M.; Taslimi, Parham; Topcu, Guelacti (WILEY-V C H VERLAG GMBH, 2018)We report the synthesis of bromoindenoquinolines (15a-f) by Friedlander reactions in low yields (13-50%) and the conversion of the corresponding phenyl-substituted indenoquinoline derivatives 16-21 in high yields (80-96%) ... -
Synthesis, characterization, crystal structures, theoretical calculations and biological evaluations of novel substituted tacrine derivatives as cholinesterase and carbonic anhydrase enzymes inhibitors
Okten, Salih; Ekiz, Makbule; Kocyigit, Umit Muhammet; Tutar, Ahmet; Celik, Ismail; Akkurt, Mehmet; Gokalp, Faik; Taslimi, Parham; Gulcin, Ilhami (ELSEVIER SCIENCE BV, 2019)The six and seven hydrocycle membered disilylanilino acridine (tacrine) analogues (9-11) were synthesized by one-pot procedures. The structures of novel silyl tacrine derivatives were characterized by NMR spectroscopy, ...
