Browsing by Author "Topcu, Omer"
Now showing items 1-17 of 17
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Altered spontaneous contractions of the ileum by anesthetic agents in rats exposed to peritonitis
Aydin, Cengiz; Bagcivan, Ihsan; Gursoy, Sinan; Altun, Ahmet; Topcu, Omer; Koyuncu, Ayhan (W J G PRESS, 2009)AIM: To investigate in vitro effects of propofol, midazolam and dexmedetomidine, which are commonly used anaesthesic or sedatives, on spontaneous contractions of the ileum both in normal rats and those exposed to hyperdynamic ... -
Effects of contrast media on the hepato-pancreato-biliary system
Topcu, Omer; Kurt, Atilla; Nadir, Isilay; Arici, Sema; Koyuncu, Ayhan; Aydin, Cengiz (W J G PRESS, 2009)AIM: To determine the effects of high osmolarity contrast media (HOCM) and iso-osmolar contrast. media (CM) application, with or without pressure, on hepato-pancreato-biliary (HPB) system. METHODS: Sixty rats were divided ... -
Effects of NO/L-Arginine Pathway on Gallbladder Contractility in Bile Duct Ligated Guinea Pigs
Soylu, Sinan; Aydin, Cengiz; Bagcivan, Ihsan; Yildirim, Sahin; Koyuncu, Ayhan; Topcu, Omer; Arici, Sema (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2009)Background. Common bile duct ligation (CBDL) produces gallbladder distension and acute inflammation similar to that seen in human acute acalculous cholecystitis. CBDL in the guinea pig affects smooth muscle contractility. ... -
Effects of Proton Pump Inhibitors and H-2 Receptor Antagonists on the Ileum Motility
Kurt, Atilla; Altun, Ahmet; Bagcivan, Ihsan; Koyuncu, Ayhan; Topcu, Omer; Aydin, Cengiz; Kaya, Tijen (HINDAWI PUBLISHING CORPORATION, 2011)Objectives. To investigate the effects of proton pump inhibitors (PPIs) and H-2 receptor antagonists on ileum motility in rats with peritonitis and compare changes with control group rats. Methods. Peritonitis was induced ... -
The effects of sildenafil in liver and kidney injury in a rat model of severe scald burn: a biochemical and histopathological study
Gokakin, Ali Kagan; Atabey, Mustafa; Deveci, Koksal; Sancakdar, Enver; Tuzcu, Mehmet; Duger, Cevdet; Topcu, Omer (TURKISH ASSOC TRAUMA EMERGENCY SURGERY, 2014)BACKGROUND: Severe burn induces systemic inflammation and reactive oxygen species leading to lipid peroxidation which may play role in remote organs injury. Sildenafil is a selective and potent inhibitor of cyclic guanosine ... -
The effects of various scolicidal agents on the hepatopancreatic biliary system
Topcu, Omer; Aydin, Cengiz; Arici, Sema; Duman, Mustafa; Koyuncu, Ayhan; Sen, Metin (KARGER, 2006)Background: Sclerosing cholangitis is a rare but dreadful complication of liver hydatid surgery. Almost all scolicidal agents were shown to be potentially associated with this complication clinically or experimentally. ... -
Efficacy of Chlorhexidine Gluconate During Surgery for Hydatid Cyst
Topcu, Omer; Sumer, Zeynep; Tuncer, Ersin; Aydin, Cengiz; Koyuncu, Ayhan (SPRINGER, 2009)Dissemination of protoscolices-rich fluid during surgery for hydatid cyst disease is a major cause of recurrence. Instillation of a scolicidal agent into a hepatic hydatid cyst before opening is the most commonly employed ... -
Expression of FHIT, p16, p53 and EGFR as prognostic markers in thyroid tumors of uncertain malignant potential
Koc, Mustafa; Aktimur, Recep; Gokakin, Ali Kagan; Atabey, Mustafa; Koyuncu, Ayhan; Elagoz, Sahende; Topcu, Omer (ZERBINIS MEDICAL PUBL, 2015)Purpose: Thyroid tumors of uncertain malignant potential (TT-UMP) constitute a relatively new diagnosis. The purpose of this study was to analyze the relationship between immunohistochemical panels, prognostic parameters ... -
The impact of Ramadan on peptic ulcer perforation
Gokakin, Ali Kagan; Kurt, Atilla; Atabey, Mustafa; Koyuncu, Ayhan; Topcu, Omer; Aydin, Cengiz; Sen, Metin; Akgol, Gunduz (TURKISH ASSOC TRAUMA EMERGENCY SURGERY, 2012)BACKGROUND Medical treatment has played an important role in the reduction of peptic ulcer perforation (PUP). The goal of this study was to evaluate the effect of fasting on PUP. METHODS A retrospective analysis of 229 ... -
Investigation of the association between the MDM2 T309G polymorphism and gastric cancer
Tas, Ayca; Atabey, Mustafa; Caglayan, Gulcin; Bostanci, Meric Emre; Bolukbasi, Serap Sahin; Topcu, Omer; Silig, Yavuz (SPANDIDOS PUBL LTD, 2017)Murine double minute clone 2 oncoprotein (MDM2) is a key component in the regulation of the tumour suppressor p53. The association between the MDM2 polymorphism and gastric cancer (GC) has been investigated in Turkish ... -
A new variant of bile duct duplication with coexistence of distal cholangiocarcinoma
Kosar, Ilkay; Ataseven, Hilmi; Yonem, Ozlem; Cakmak, Erol; Ozer, Oezdemir; Ozer, Hatice; Topcu, Omer (NATURE PUBLISHING GROUP, 2010)Background. A 72-year-old hypertensive woman presented with a 2-month history of right upper quadrant abdominal pain. She had a 15-day history of jaundice, fever with chills and shivering, nausea, vomiting, weight loss and ... -
Oxidative stress markers in laparoscopic vs. open appendectomy for acute appendicitis: A double-blind randomized study
Aktimur, Recep; Gokakin, Ali Kagan; Deveci, Koksal; Atabey, Mustafa; Topcu, Omer (MEDKNOW PUBLICATIONS & MEDIA PVT LTD, 2016)Background: Oxidative stress is a complicated process, which was defined as an increase in prooxidants and decrease in antioxidants caused by various mechanisms, including inflammation and surgical trauma. The association ... -
Peptic Ulcer Perforation in Elderly: 10 years' Experience of a Single Institution
Gokakin, Ali K.; Atabey, Mustafa; Koyuncu, Ayhan; Topcu, Omer (ELSEVIER TAIWAN, 2016)Background: Peptic ulcer perforation (PUP) constitutes a unique situation characterized by severe pain, leading almost every patient with this complication to seek help in the hospital. However, clinical features of PUP ... -
The protective effects of sildenafil in acute lung injury in a rat model of severe scald burn: A biochemical and histopathological study
Gokakin, Ali Kagan; Deveci, Koksal; Kurt, Atilla; Karakus, Boran Cihat; Duger, Cevdet; Tuzcu, Mehmet; Topcu, Omer (ELSEVIER SCI LTD, 2013)Severe burn induces biochemical mediators such as reactive oxygen species that leads to lipid peroxidation which may have a key role in formation of acute lung injury (ALI). Sildenafil is a selective and potent inhibitor ... -
Psychosis Association with Graves Thyrotoxicosis: A Case Report
Kugu, Nesim; Dogan, Orhan; Topcu, Omer; Kavakci, Onder; Karsikaya, Sureyya (UNIVERSITATSVERLAG ULM GMBH, 2008)Graves disease is ail autoimmune and multifactorial disease of the thyroid gland and one of the commonest reasons of the hyperthyroidism. Most of the Graves disease patients show typical symptoms of the disease such as ... -
Significant association between MDM2 T309G polymorphism and colorectal cancer
Atabey, Mustafa; Tas, Ayca; Sari, Ismail; Bostanci, Meric Emre; Topcu, Omer; Silig, Yavuz (IMPRIMATUR PUBLICATIONS, 2019)Purpose: The Murine double minute 2 (MDM2) gene plays a crucial role in regulating and suppressing the function of apoptotic pathway. We investigated the relationship between MDM2 gene SNP309 (T309G) (rs2279744) polymorphism ...
