Browsing by Author "Uludag, Ahmet"
Now showing items 1-11 of 11
-
Association between ABCB1 (MDR1) Gene 3435 C > T Polymorphism and Colchicine Unresponsiveness of FMF Patients
Ozen, Filiz; Silan, Coskun; Uludag, Ahmet; Candan, Ferhan; Silan, Fatma; Ozdemir, Semra; Atik, Sinem; Ozdemir, Ozturk (TAYLOR & FRANCIS LTD, 2011)The multidrug resistance gene-1 (MDR1, adenosine triphosphate-binding cassette transporter: ABCB1, P-glycoprotein) encodes membrane proteins that play a crucial role in protecting cells from xenobiotics, chemicals, and ... -
Association of endothelial nitric oxide synthase Glu298Asp gene polymorphism in psoriasis cases with hypertension
Ogretmen, Zerrin; Hiz, Meliha Merve; Silan, Fatma; Uludag, Ahmet; Ozdemir, Ozturk (K FAISAL SPEC HOSP RES CENTRE, 2014)BACKGROUND AND OBJECTIVES: Psoriasis is a common autoimmune-mediated chronic, inflammatory skin disease. Although, the molecular mechanism is not completely understood, psoriasis is caused by genetic and non-genetic ... -
Combined Effect of Factor V Leiden, MTHFR, and Angiotensin-Converting Enzyme (Insertion/Deletion) Gene Mutations in Hypertensive Adult Individuals: A Population-Based Study from Sivas and Canakkale, Turkey
Demirel, Yeltekin; Dogan, Sezai; Uludag, Ahmet; Silan, Coskun; Atik, Sinem; Silan, Fatma; Ozdemir, Ozturk (MARY ANN LIEBERT INC, 2011)Background: Hypertension is one of the leading causes of mortality and morbidity in the world, which is influenced by environmental and genetic factors. The methylenetetrahydrofolate reductase (MTHFR) and angiotensin-converting ... -
Combined point mutations in codon 12 and 13 of KRAS oncogene in prostate carcinomas
Silan, Fatma; Gultekin, Yener; Atik, Sinem; Kilinc, Davran; Alan, Cabir; Yildiz, Fazilet; Uludag, Ahmet; Ozdemir, Ozturk (SPRINGER, 2012)Prostate cancer is a common malignancy that develops by structural mutation(s) and/or other genetic alterations in specific genes.The G to T transversions in codon 12 and C to T transitions in codon 13 of KRAS proto-oncogene ... -
The CYP4502D6*4 and*6 alleles are the molecular genetic markers for drug response: implications in colchicine non-responder FMF patients
Yalcintepe, Sinem; Ozdemir, Ozturk; Silan, Coskun; Ozen, Filiz; Uludag, Ahmet; Candan, Ferhan; Silan, Fatma (SPRINGER FRANCE, 2016)The cytochrome P450 2D6 (CYP2D6) is a cytochrome P450 enzyme involved in the oxidative biotransformation of the xenobiotics, carcinogens and various clinically important drugs. Patients are evaluated in three sub-groups ... -
Germ-line MTHFR C677T, FV H1299R and PAI-1 5G/4G Variations in Breast Carcinoma
Ozen, Filiz; Erdis, Eda; Sik, Ebru; Silan, Fatma; Uludag, Ahmet; Ozdemir, Ozturk (ASIAN PACIFIC ORGANIZATION CANCER PREVENTION, 2013)Background: Various oncogenes related to cancer have been extensively studied and several polymorphisms have been found to be associated with breast cancer. The current report outlines analysis of germ-line polymorphisms ... -
Increased T-Allele Frequency of 677 C > T Polymorphism in the Methylenetetrahydrofolate Reductase Gene in Differentiated Thyroid Carcinoma
Ozdemir, Semra; Silan, Fatma; Hasbek, Zekiye; Uludag, Ahmet; Atik, Sinem; Erselcan, Taner; Ozdemir, Ozturk (MARY ANN LIEBERT INC, 2012)Background: Epigenetic alterations in the global DNA methylation status may be associated with an increased risk of some cancer types in humans. The methylenetetrahydrofolate reductase (MTHFR) gene is involved in folic ... -
Multiple Inherited Thrombophilic Gene Polymorphisms in Spontaneous Abortions in Turkish Population
Yalcintepe, Sinem; Ozdemir, Ozturk; Hacivelioglu, Servet Ozden; Akurut, Cisem; Koc, Evrim; Uludag, Ahmet; Cosar, Emine; Silan, Fatma (CELLULAR & MOLECULAR BIOLOGY RESEARCH CENTER, 2015)The aim of this study was to investigate the possible role of multiple inherited thrombophilic gene variations in women with unexplained spontaneous abortions. For this purpose, the Factor V Leiden (FVL) (rs6025), Prothrombin ... -
Possible Roles of the Xenobiotic Transporter P-glycoproteins Encoded by the MDR1 3435 C > T Gene Polymorphism in Differentiated Thyroid Cancers
Ozdemir, Semra; Uludag, Ahmet; Silan, Fatma; Atik, Sinem Yalcintepe; Turgut, Bulent; Ozdemir, Ozturk (ASIAN PACIFIC ORGANIZATION CANCER PREVENTION, 2013)Background: P-glycoprotein (Pgp), encoded by the multidrug resistance 1 (MDR1) gene, is an efflux transporter which plays an important role in pharmacokinetics. The current preliminary study was designed to determine ... -
The prevalence of VKORC1 1639 G > A and CYP2C9*2*3 genotypes in patients that requiring anticoagulant therapy in Turkish population
Silan, Coskun; Dogan, Omer Tamer; Silan, Fatma; Kukulguven, Fatma Mutlu; Asgun, Halil Fatih; Ozdemir, Semra; Uludag, Ahmet; Atik, Sinem; Gungor, Buket; Akdur, Secil; Aksulu, Hakki Engin; Ozdemir, Ozturk (SPRINGER, 2012)The aim was to investigate the prevalence of VKORC1 and CYP2C9 genotypes in patients requiring anticoagulant therapy in two different region's populations of Turkey. The recent cohort included 292 patients that needed ...
