Browsing by Author "Yildirim, Sahin"
Now showing items 1-17 of 17
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Changes in spontaneous contractions of rat ileum by aflatoxin in vitro
Gursoy, Nevcihan; Sarac, Bulent; Durmus, Nedim; Parlak, Ahmet; Yildirim, Sahin; Kaya, Tijen; Bagcivan, Ihsan (PERGAMON-ELSEVIER SCIENCE LTD, 2008)Aflatoxins are a group of mycotoxins produced by toxigenic strains of Aspergillus flavus, Aspergillus parasiticus and Aspergillus nomius as secondary metabolites. Most of the studies on the aflatoxins have focused mainly ... -
Contractile responses of urinary bladder in an experimental model of chronic renal failure
Bicer, Huseyin; Korgali, Esat; Gokce, Gokhan; Ayan, Semih; Yildirim, Sahin; Gultekin, E. Yener (ASSOC BASIC MEDICAL SCI FEDERATION BOSNIA & HERZEGOVINA SARAJEVO, 2012)Chronic kidney disease is a public health problem with increasing prevalence caused by diabetes, hypertension and glomerulonephritis. Number of publications investigate the lower urinary tract dysfunction due to CKD is ... -
Cyclosporine-A induces apoptosis in human prostate cancer cells PC3 and DU145 via downregulation of COX-2 and upregulation of TGF beta
Cevik, Ozge; Turut, Fatma Aysun; Acidereli, Hilal; Yildirim, Sahin (WALTER DE GRUYTER GMBH, 2019)Background: Potential targets for prostate cancer therapy are urgently needed for curative of patients. Cyclosporine-A (CsA), an immunosuppressive and a selective cyclooxygenase-2 (COX-2) inhibitor, exerts antitumor activity. ... -
CYTOTOXIC AND ANTIBACTERIAL ACTIVITY OF THE MIXTURE OF OLIVE OIL AND LIME CREAM IN VITRO CONDITIONS
Sumer, Zeynep; Yildirim, Gulay; Sumer, Haldun; Yildirim, Sahin (AFRICAN NETWORKS ETHNOMEDICINES, 2013)The mixture of olive oil and lime cream has been traditionally used to treat external burns in the region of Hatay/Antakya and middle Anatolia. Olive oil and lime cream have been employed by many physicians to treat in ... -
Effects of NO/L-Arginine Pathway on Gallbladder Contractility in Bile Duct Ligated Guinea Pigs
Soylu, Sinan; Aydin, Cengiz; Bagcivan, Ihsan; Yildirim, Sahin; Koyuncu, Ayhan; Topcu, Omer; Arici, Sema (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2009)Background. Common bile duct ligation (CBDL) produces gallbladder distension and acute inflammation similar to that seen in human acute acalculous cholecystitis. CBDL in the guinea pig affects smooth muscle contractility. ... -
In vitro evaluation of nebivolol effects on nonadrenergic noncholinergic responses in rabbit corpus cavernosum
Aydin, Kaya; Gokcen, Kaan; Yildirim, Sahin; Bagcivan, Ihsan; Parlak, Mesut; Gokce, Goekhan (WILEY, 2018)The purpose of this study was to compare the effects of nebivolol on nonadrenergic noncholinergic (NANC) relaxation functions that are mediated by electric field stimulation (EFS) in rabbit corpus cavernosum smooth muscle ... -
Investigating the effects of the Rho-kinase enzyme inhibitors AS1892802 and fasudil hydrochloride on the contractions of isolated pregnant rat myometrium
Ergul, Merve; Turgut, Nergiz H.; Sarac, Bulent; Altun, Ahmet; Yildirim, Sahin; Bagcivan, Ihsan (ELSEVIER SCIENCE BV, 2016)Objectives: Rho-kinases (ROCKs), are one of the dynamic structures of the actin cytoskeleton and they mediate different biological processes, including regulation of calcium sensitivity of smooth muscle contraction. The ... -
Investigation of acute effects of aflatoxin on rat proximal and distal colon spontaneous contractions
Gursoy, Nevcihan; Durmus, Nedim; Bagcivan, Ihsan; Sarac, Bulent; Parlak, Ahmet; Yildirim, Sahin; Kaya, Tijen (PERGAMON-ELSEVIER SCIENCE LTD, 2008)Aflatoxins are one of the most potent toxic, mutagenic, teratogenic, cancerogenic, and immunosuppresive substances that naturally Occurring contaminants of food. There are some studies in various animal species that have ... -
Investigation of relaxant effects of propofol on sheep sphincter of Oddi
Bagcivan, Ihsan; Gursoy, Sinan; Yildirim, M. Kemal; Temiz, Tijen Kaya; Yildirim, Sahin; Yilmaz, Abdulkerim; Turan, Mustafa (KARGER, 2007)Background/Aims: Intravenous anesthetics are often used for conscious sedation in endoscopic retrograde cholangio-pancreatography ( ERCP) and endoscopic sphincter of Oddi ( SO) manometry. This study was designed to investigate ... -
Investigation of the Cardiac Effects of Pancuronium, Rocuronium, Vecuronium, and Mivacurium on the Isolated Rat Atrium
Gursoy, Sinan; Bagcivan, Ihsan; Durmus, Nedim; Kaygusuz, Kenan; Kol, Iclal Ozdemir; Duger, Cevdet; Yildirim, Sahin; Mimaroglu, Caner (ELSEVIER SCIENCE INC, 2011)BACKGROUND: Pancuronium, vecuronium, rocuronium, and mivacurium are nondepolarizing neuromuscular blocking agents that affect the cardiovascular system with different potencies. Their cardiovascular effects are clinically ... -
Investigation of the Relaxant Effect Mechanism of Ketamine on Normal and Ovalbumin-Induced Trachea in Guinea Pigs
Sarac, Bulent; Altun, Ahmet; Yildirim, Sahin; Yildirim, Mustafa Kemal; Temiz, Tijen Kaya; Bagcivan, Ihsan; Sencan, Mehmet (ORTADOGU AD PRES & PUBL CO, 2011)Objective: The aim of this study was to investigate of effects and the possible mechanisms of effects of ketamine on the isolated trachea preparations from control and ovalbumin sensitized guinea pigs. Material and Methods: ... -
Investigation of the relaxant effects of pancuronium, rocuronium, vecuronium and mivacurium on rat thoracic aorta
Gursoy, Sinan; Bagcivan, Ihsan; Durmus, Nedim; Kaygusuz, Kenan; Kol, Iclal Ozdemir; Yildirim, Sahin; Mimaroglu, Caner (LIPPINCOTT WILLIAMS & WILKINS, 2009)Background and objective Pancuronium, vecuronium, mivacurium and rocuronium are nondepolarizing neuromuscular blocking agents, which are competitive antagonists against acetylcholine at nicotinic receptors, and considered ... -
Investigation of the vasorelaxant effects of 3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole (YC-1) and diethylamine/nitric oxide (DEA/NO) on the human radial artery used as coronary bypass graft
Berkan, Ocal; Bagcivan, Ihsan; Kaya, Tijen; Yildirim, Kemal; Yildirim, Sahin; Dogan, Kasim (NATL RESEARCH COUNCIL CANADA-N R C RESEARCH PRESS, 2007)The radial artery (RA) is used as a spastic coronary bypass graft. This study was designed to investigate the mechanism of vasorelaxant effects of YC-1 (3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole), a nitric oxide ... -
Investigation of the vasorelaxant effects of moxonidine and its relaxation mechanism on the human radial artery when used as a coronary bypass graft
Sarac, Bulent; Korkmaz, Ozge; Altun, Ahmet; Bagcivan, Ihsan; Goksel, Sabahattin; Yildirim, Sahin; Berkan, Ocal (OXFORD UNIV PRESS, 2015)In both low- and high-risk patients undergoing coronary artery bypass grafting, the internal mammary artery is the first choice of arterial graft, and the second choice is the radial artery (RA). Unfortunately, RA spasms ... -
Labetalol, nebivolol, and propranolol relax human radial artery used as coronary bypass graft
Korkmaz, Ozge; Sarac, Bulent; Goksel, Sabahattin; Yildirim, Sahin; Berkan, Ocal; Bagcivan, Ihsan (MOSBY-ELSEVIER, 2015)Objective: Beta-blockers are a heterogeneous class of agents that are used in the treatment of many cardiovascular diseases, especially hypertension and atherosclerosis, and that are commonly prescribed after cardiac ... -
Lack of nitrate tolerance in isosorbid dinitrate- and sodium nitroprusside-induced relaxation of rabbit internal anal sphincter
Koyuncu, Ayhan; Bagcivan, Ihsan; Sarac, Bulent; Aydin, Cengiz; Yildirim, Sahin; Sarioglu, Yusuf (BAISHIDENG PUBL GRP CO LTD, 2008)AIM: To investigate the tolerance development against the relaxant effect of nitric oxide donating drug isosorbide dinitrate (ISDN) and sodium nitropruside (SNP) in internal anal sphincter (IAS) smooth muscle. METHODS: ... -
Role of new agents affecting NO/cGMP pathway on ovalbumin-sensitized guinea pig trachea
Parlak, Ahmet; Yildirim, Sahin; Bagcivan, Ihsan; Durmus, Nedim (INFORMA HEALTHCARE, 2012)Asthma is a chronic inflammatory disease in which cell components play important roles. We aimed to evaluate the effects of NO/cGMP cleavage at trachea preparations isolated from ovalbumin-sensitized guinea pigs in vitro. ...
