Kimya Mühendisliği Bölümühttps://hdl.handle.net/20.500.12418/5452024-03-28T15:34:49Z2024-03-28T15:34:49ZMetabolomics in Biomarker Identification for Cardiovascular Diseases, Metabolomics and Clinical ApproachAvcı, Mesudehttps://hdl.handle.net/20.500.12418/150872024-03-08T21:47:33Z2023-01-01T00:00:00ZMetabolomics in Biomarker Identification for Cardiovascular Diseases, Metabolomics and Clinical Approach
Avcı, Mesude
Metabolomics is the systematic analysis of the particular chemical
fingerprints of small molecules or metabolite profiles which are
associated with a different cellular metabolic process in a cell, organ, or
organism. Events in a cell are not described completely by messenger
RNA gene expression data and proteomic analyses, but metabolic
profiling supplies direct and indirect physiological insights, which can
possibly be measurable in a broad range of biospecimens. Even though
not specific to cardiac conditions, identification, confirmation, clinical
validation, and bedside tests are a biomarker exploration path to translate
metabolomics into cardiovascular biomarkers. Technological progress in
metabolomic tools (such as nuclear magnetic resonance spectroscopy and
mass spectrometry) and more complicated bioinformatics and analytical
techniques help to evaluate low- molecular-weight metabolites in
biospecimens and ultimately supply a unique insight into determined and
novel metabolic pathways. Systematic metabolomics can provide
physiological knowledge of cardiovascular disease states in addition to
traditional profiling and can include the definition of metabolic reactions
of an individual or population to therapeutic interventions or
environmental exposures.
2023-01-01T00:00:00ZEvaluation of factors affecting tetracycline and diclofenac adsorption by agricultural soils using response surface methodologyGÜLER ÜLKER ASLI, TUNCEL Eliza, ERŞAN MEHTAPhttps://hdl.handle.net/20.500.12418/147442024-03-06T21:47:28Z2023-01-01T00:00:00ZEvaluation of factors affecting tetracycline and diclofenac adsorption by agricultural soils using response surface methodology
GÜLER ÜLKER ASLI, TUNCEL Eliza, ERŞAN MEHTAP
The adsorption process of the pharmaceutical pollutant in the soil is affected by its physicochemical properties and soil properties. In this study, the factors affecting the adsorption of tetracycline and diclofenac onto two different soils (S and M) were investigated using response surface methodology (RSM). The RSM design was used to optimize the five variable factors (pH (2–10), contact time (5–180 min), soil amount (1–10 g/L), temperature (25–45°C)) on the adsorption of tetracycline and diclofenac. The predicted optimal conditions obtained by RSM showed that pH was the most important variable affecting the adsorption of tetracycline and diclofenac. The optimum pH for the adsorption of tetracycline and diclofenac onto the soil samples S and M were found to be 4 and 2, respectively. The adsorbed amounts of tetracycline and diclofenac onto the soils S and M were calculated to be 14.82 mg/g, 12.43 mg/g, 189.40 mg/g, and 144.81 mg/g, respectively. In addition, the effects of soil organic matter, salt, and divalent cations on the adsorption of tetracycline and diclofenac onto soils were studied. The removal of soil organic matter slightly increased tetracycline adsorption, while inhibiting diclofenac adsorption. The presence of salt and divalent cations prominently suppressed the adsorption of tetracycline and diclofenac onto soils. A possible complex mechanism was proposed for TC and DCF adsorption, including ion exchange, electrostatic interaction, and some chemical bonds.
2023-01-01T00:00:00ZNanoengineering and nanoscience:current and emerging trendsKütük, NurşahGürbüzer, AslıhanTüzün, GamzeTüzün,Burakhttps://hdl.handle.net/20.500.12418/147372024-03-06T21:47:27Z2023-01-01T00:00:00ZNanoengineering and nanoscience:current and emerging trends
Kütük, Nurşah; Gürbüzer, Aslıhan; Tüzün, Gamze; Tüzün,Burak
The study of science at the nanoscale has become one of the most important
research topics in recent years. Almost all branches of science are interested in nanotechnology.
Metal and metal oxides, carbon family products, polymers, clays and composites
are some of the nanomaterials used. Despite their small size, nanomaterials
have different properties such as large surface area, different particle shape and size,
pore volume, biocompatibility and biodispersibility. For this reason, nanotechnology
has also spread to the industry. Due to their unique properties, nanomaterials are
widely used in medical, water treatment, sensor and environmental applications. Although
nanotechnology research has accelerated especially in recent years, there are
still many unexplored materials and application areas. The aim of this study is to investigate
the advantages and disadvantages of nanomaterials and nanotechnology applications
by examining their usage areas in scientific and industrial fields.
2023-01-01T00:00:00ZAlkaline activation synthesis by graphite/calcite mortar and the effect of experimental conditions on compressive strengthKütük, NurşahÇetinkaya Gürer, Sevilhttps://hdl.handle.net/20.500.12418/147362024-03-06T21:47:27Z0020-01-01T00:00:00ZAlkaline activation synthesis by graphite/calcite mortar and the effect of experimental conditions on compressive strength
Kütük, Nurşah; Çetinkaya Gürer, Sevil
The construction industry is an application area that has continuity all over the world and requires cheap, durable, and environmentally friendly materials. Synthesis with alkali activation includes materials that have come to the fore in the construction industry in recent years. In this study using alkali activation method, a graphite/calcite mortar was prepared by optimizing the experimental conditions and its properties were investigated. The effects of Na2SiO3/NaOH mass ratio, NaOH solution concentration, and graphite content variables on structure and compressive strength in alkaline activation synthesis were investigated. It was determined that the samples reached a compressive strength of 21 MPa at the end of 28 days when the Na2SiO3/NaOH ratio was 2 and the NaOH concentration was 10 M. In the continuation of the optimized experimental conditions, the effect of the amount of graphite on the compressive strength was examined between 5 and 100% (w/w). Structural properties of the samples were investigated by X-ray diffraction and Fourier transform infrared spectroscopy, and their morphological properties were investigated by scanning electron microscopy. It was determined that C–S–H gel was formed and samples with heterogeneous morphology were synthesized.
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