Biological evaluation and in silico molecular docking studies of Abies cilicica (Antoine & Kotschy) Carri`ere) resin
Tarih
2023Üst veri
Tüm öğe kaydını gösterÖzet
Abies cilicica (Antoine & Kotschy) Carri`ere) is an endemic species of industrial and medicinal importance. The
resin obtained from this plant is effective for different diseases. The chemical content of the ethanol extract of
Abies cilicica resin by GC-MS method, its antimicrobial activity on 12 different microorganisms by MIC value,
antibiofilm activity on six microorganisms by Christensen method and biological activities on three different
cancer cell lines by MTT method were investigated in this study. The findings showed that antimicrobial and
antibiofilm activity was high in L. monocytogenes. The resin extract showed strong anticancer activity on all three
DU-145, HeLa and SaOS-2 cells. The major component of the resin was abietic acid. A molecular docking
simulation of the major compounds from resin extracts was conducted. In this study, in which the strong biological
properties of A.cilicica resin were revealed, which suggests that the resin can increase the inhibition of
cancer cell growth while strengthening the immune system against pathogenic microorganisms. Molecular
docking analysis performed supported the experimental observations. Further extensive studies will support the
possibility of using this resin as a therapeutic agent.
Kaynak
Journal of Molecular StructureCilt
1288Sayı
135740Bağlantı
https://www.sciencedirect.com/science/article/pii/S0022286023008360?via%3Dihubhttps://hdl.handle.net/20.500.12418/14747