Browsing Makale Koleksiyonu by Title
Now showing items 5295-5314 of 5745
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Synthesis, characterization, anticancer, antimicrobial and carbonic anhydrase inhibition profiles of novel (3aR,4S,7R,7aS)-2-(4-((E)-3-(3-aryl)acryloyl) phenyl)-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione derivatives
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2017)In the present study, a series of new hybrid compounds containing chalcone and methanoisoindole units 7a-n ((3aR,4S,7R,7aS)-2-(4-((E)-3-(3-aryl) acryloyl) phenyl)-3a, 4,7,7a-tetrahydro-1H-4,7-methanoisoin dole-1,3(2H)-dione) ... -
Synthesis, characterization, crystal structures, theoretical calculations and biological evaluations of novel substituted tacrine derivatives as cholinesterase and carbonic anhydrase enzymes inhibitors
(ELSEVIER SCIENCE BV, 2019)The six and seven hydrocycle membered disilylanilino acridine (tacrine) analogues (9-11) were synthesized by one-pot procedures. The structures of novel silyl tacrine derivatives were characterized by NMR spectroscopy, ... -
Synthesis, Crystal and Molecular Structure of 2',3',3'-Tribromo-2',3'-dihydrospiro[1,3-dioxolane-2,1'-indene]
(SPRINGER/PLENUM PUBLISHERS, 2013)The crystal structure of 2',3',3'-tribromo-2',3'-dihydrospiro[1,3-dioxolane-2,1'-indene], (C11H9Br3O2 ), has been determined by means of single-crystal X-ray diffraction methods. The title compound crystallizes in the ... -
Synthesis, Crystal Structure and Theoretical Characterization of (3R, 4R, 6S)-3,6-Dihydroxy-1-Menthene Isolated from Echinophora Tenuifolia
(GAZI UNIV, 2016)In the title compound, C10H18O2, the cyclohexene ring adopts a half-chair conformation. In the crystal strcuture, weak inter(sic)molecular O-H center dot center dot center dot O hydrogen bonds connect the adjacent molecules, ... -
Synthesis, Cytotoxicity, and Pro-Apoptosis Activity of Etodolac Hydrazide Derivatives as Anticancer Agents
(WILEY-V C H VERLAG GMBH, 2013)Etodolac hydrazide and a novel series of etodolac hydrazide-hydrazones 315 and etodolac 4-thiazolidinones 1626 were synthesized in this study. The structures of the new compounds were determined by spectral (FT-IR, 1H NMR, ... -
Synthesis, Molecular Docking and Anticancer Activity of Diflunisal Derivatives as Cyclooxygenase Enzyme Inhibitors
(MDPI, 2018)Cyclooxygenase enzymes play a vital role in inflammatory pathways in the human body. Apart from their relation with inflammation, the additional involvement of COX-2 enzyme with cancer activity was recently discovered. In ... -
Synthesis, molecular docking, and antitumoral activity of alnustone-like compounds against estrogen receptor alpha-positive human breast cancer
(SCIENTIFIC TECHNICAL RESEARCH COUNCIL TURKEY-TUBITAK, 2015)Alnustone-like compounds are promising inhibitors for estrogen receptor alpha (ER-alpha), which is a novel cancer therapeutic target. Therefore, 10 alnustone-like compounds with substituents at the phenyl rings were ... -
Synthesis, Molecular Modelling and Antibacterial Activity Against Helicobacter pylori of Novel Diflunisal Derivatives as Urease Enzyme Inhibitors
(BENTHAM SCIENCE PUBL LTD, 2019)Background: The main factor for the prolongation of the ulcer treatment in the gastrointestinal system would be Helicobacter pylori infection, which can possibly lead to gastrointestinal cancer. Triple therapy is the ... -
Synthesis, spectral analysis and quantum chemical studies on molecular geometry, chemical reactivity of 7-chloro-9-(2 '-chlo rophenyl)-2,3-dihydroacridin-4(1H)-one and 7-chloro-9-(2 '-fluo rophenyl)-2,3-dihydroacridin-4(1H)-one
(ELSEVIER SCIENCE BV, 2017)7-Chloro-9-(2'-chlorophenyl)-2,3-dihydroacridin-4(1H)-one (3a) and 7-chloro-9-(2'-fluorophenyl)-2,3dihydroacridin-4-(1H)-one (3b) were synthesized from 2-amino-2',5-dichlorobenzophenone (1a) and 2-amino-5-chloro-2'-fluor ... -
Synthesis, spectral, X-ray diffraction and DFT studies on 1-(2-methyl-2-propenyl)-3-(2,3,4,5,6-pentamethylbenzyl)benzimidazolium chloride hydrate
(TAYLOR & FRANCIS LTD, 2018)A new benzimidazole based N-heterocyclic carbene (NHC) salt (1) was synthesized by the reaction of benzimidazole precursor with alkyl halide. The structure of 1 was determined by elemental analysis, FT-IR, H-1 NMR and C-13 ... -
Synthesis, spectroscopic characterization, calculational studies and in vitro antitumoral activity of 4-(3-(1H-imidazol-1-yl)propyl)-(thiophen-2-ylmethyl)-1H-1,2,4-triazol-5(4H)-one
(ELSEVIER SCIENCE BV, 2011)4-(3-(1H-imidazol-1-yl)propyl)-(thiophen-2-ylmethyl)-1H-1.2,4-triazol-5(4H)-one (IPTT), C13H15N5OS, was synthesized and characterized by C-13 NMR, H-1 NMR, IR and single-crystal X-ray diffraction. The structure of IPTT is ... -
Synthesis, spectroscopic, in vitro cytotoxicity and crystal structures of novel fluorinated dispiroheterocycles: DFT approach
(SPRINGER WIEN, 2018)The reaction of azomethine ylide generated in situ from ninhydrin and sarcosine/thiaproline with fluorinated cyclopent[b]indole dipolarophiles in refluxing dioxane and methanol afforded a novel class of fluorinated ... -
Synthesis, structural characterization, and antiproliferative/cytotoxic effects of a novel modified poly(maleic anhydride-co-vinyl acetate)/doxorubicin conjugate
(SPRINGER, 2017)Drug carrier, poly(maleic anhydride-co-vinyl acetate) (MAVA or poly[MA-co-VA]) copolymer, was traditionally synthesized by free radical chain polymerization reaction, in methyl ethyl ketone (MEK) organic media at 80 A ... -
A synthesis: Late Cenozoic stress field distribution at northeastern corner of the Eastern Mediterranean, SE Turkey
(EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2004)Fault kinematic analysis and inversion of focal mechanisms of shallow earthquakes reveal significant evolution of the regional stress regime in the northeastern most corner of the Eastern Mediterranean region since the ... -
Systematic assessment of electrocoagulation for the treatment of marble processing wastewater
(SPRINGER, 2012)In this study, the treatability of marble processing wastewater by electrocoagulation using aluminum and iron electrodes was investigated. The sample used was from the marble-processing plant in Sivas and its turbidity, ... -
Systematic Evaluation of Promising Clinical Trials-Gene Silencing for the Treatment of Glioblastoma
(TURKISH NEUROSURGICAL SOC, 2019)AIM: To systematically investigate the role of artificial small interfering RNA (SiRNA) molecules in glioblastoma treatment and to give a detailed overview of the literature concerning studies performed in this field ... -
Systematics and biostratigraphy of Oligocene (Rupelian-Early Chattian) foraminifera from lagoonal-very shallow water limestone in the eastern Sivas Basin (central Turkey)
(INST GEOLOSKA ISTRAZIVANJA, 2013)The aim of the present work is to describe the Oligocene (Rupelian-early Chattian) shallow water larger foraminifera from central Turkey (Sivas Basin). Among them is a new miliolid genus, Sivasina n. gen. SIREL & OZGEN-ERDEM ... -
Systemic effects of H2S inhalation at human equivalent dose of pathologic halitosis on rats
(TAYLOR & FRANCIS LTD, 2017)Objectives: Halitosis is composed by hundreds of toxic gases. It is still not clear whether halitosis gases self-inhaled by halitosis patients cause side effects. The aim of the study was to investigate the effect of H2S ... -
Systemic Prolidase Activity and Oxidative Stress in Keratoconus
(TAYLOR & FRANCIS INC, 2016)Aim: Our aim was to evaluate the serum prolidase activity, total antioxidant capacity (TAC) and total oxidant status (TOS) in patients with keratoconus.Material and method: A total 69 keratoconus patients and 72 control ... -
Systemic propolis stimulates new bone formation at the expanded suture A histomorphometric study
(E H ANGLE EDUCATION RESEARCH FOUNDATION, INC, 2013)Objective: To investigate the effects of systemically given propolis on the expanded premaxillary suture in a rat study model. Materials and Methods: The 24 rats were randomly divided into three groups only expansion (OE), ...