Browsing Makale Koleksiyonu by Author "Bagcivan, Ihsan"
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Additive interaction of intraperitoneal dexmedetomidine and topical nimesulide, celecoxib, and DFU for antinociception
Karadas, Baris; Kaya, Tijen; Gulturk, Sefa; Parlak, Ahmet; Gursoy, Sinan; Cetin, Ali; Bagcivan, Ihsan (ELSEVIER SCIENCE BV, 2007)Nimesulide, celecoxib, and DFU (5, 5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulphonyl)phenyl-2(5H)-furanone) are nonsteroidal antiinflammatory drugs (NSAIDs) with selective cyclo-oxygenase (COX)-2 blocking properties and ... -
Alterations in spontaneous contractions of rat proximal and distal colon after peritonitis
Yildiz, Turan; Koyluoglu, Gokhan; Bagcivan, Ihsan; Kaya, Tijen; Karadas, Bans; Sarac, Buelent; Cankorkmaz, Levent (W B SAUNDERS CO-ELSEVIER INC, 2007)Background/ Purpose: The aim of this study was to investigate the effect of peritonitis on spontaneous contractions of distal and proximal colon smooth muscle isolated from rats. Methods: Peritonitis was induced by cecal ... -
Altered spontaneous contractions of the ileum by anesthetic agents in rats exposed to peritonitis
Aydin, Cengiz; Bagcivan, Ihsan; Gursoy, Sinan; Altun, Ahmet; Topcu, Omer; Koyuncu, Ayhan (W J G PRESS, 2009)AIM: To investigate in vitro effects of propofol, midazolam and dexmedetomidine, which are commonly used anaesthesic or sedatives, on spontaneous contractions of the ileum both in normal rats and those exposed to hyperdynamic ... -
Attenuation of morphine antinociceptive tolerance by cannabinoid CB1 and CB2 receptor antagonists
Altun, Ahmet; Yildirim, Kemal; Ozdemir, Ercan; Bagcivan, Ihsan; Gursoy, Sinan; Durmus, Nedim (SPRINGER JAPAN KK, 2015)Cannabinoid CB1 and CB2 receptor antagonists may be useful for their potential to increase or prolong opioid analgesia while attenuating the development of opioid tolerance. The aim of this study was to investigate the ... -
Changes in spontaneous contractions of rat ileum by aflatoxin in vitro
Gursoy, Nevcihan; Sarac, Bulent; Durmus, Nedim; Parlak, Ahmet; Yildirim, Sahin; Kaya, Tijen; Bagcivan, Ihsan (PERGAMON-ELSEVIER SCIENCE LTD, 2008)Aflatoxins are a group of mycotoxins produced by toxigenic strains of Aspergillus flavus, Aspergillus parasiticus and Aspergillus nomius as secondary metabolites. Most of the studies on the aflatoxins have focused mainly ... -
Comparative Relaxant Effects of Ataciguat and Zaprinast on Sheep Sphincter of Oddi
Cakmak, Erol; Yonem, Ozlem; Sarac, Bulent; Parlak, Mesut; Celik, Cumali; Ataseven, Hilmi; Bagcivan, Ihsan (GALENOS YAYINCILIK, 2016)Background: Relaxing the sphincter of Oddi (SO) is an important process during endoscopic retrograde cholangiopancreatography (ERCP) procedures. This issue suggests that the easier the sphincterotomy and cannulation, the ... -
Comparative relaxant effects of YC-1 and DEA/NO on the sheep sphincter of Oddi
Bagcivan, Ihsan; Kaya, Tijen; Turan, Mustafa; Karadas, Baris; Sarac, Buelent; Duman, Mustafa (KARGER, 2006)Background/Aims: Nitric oxide (NO) is a major inhibitor in various parts of the gastrointestinal tract. This study was designed to compare the effects of YC-1, NO-independent soluble guanylate cyclase (sGC) activator, and ... -
Comparison of In Vitro Effects of Opioid Analgesics on Spontaneous Proximal and Distal Colon Contractions in Healthy Rats and Rats with Peritonitis
Ersan, Idris; Gursoy, Sinan; Avci, Onur; Altun, Ahmet; Bagcivan, Ihsan; Duger, Cevdet; Kol, Iclal Ozdemir; Kaygusuz, Kenan; Mimaroglu, Mehmet Caner (AVES, 2018)Objective: The goal of this study was to investigate and compare the effects of opioids on proximal and distal colon contractions in normal rats and rats with peritonitis, with and without the presence of naloxone in the ... -
Do antibiotics contribute to postoperative ileus? Contractile responses of ileum smooth muscle in guinea pigs to long-term parenteral ceftriaxone and ampicillin
Ceran, Canan; Karadas, Baris; Kaya, Tijen; Arpacik, Mehmet; Bagcivan, Ihsan; Sarac, Buelent (BLACKWELL PUBLISHING, 2006)Background: Antibiotics may impair small bowel smooth muscle contractility and contribute to postoperative ileus. The aim of this study was to compare the contractile responses of ileum smooth muscle to different agonists ... -
Effect of hypothyroidism on the NO/cGMP pathway of corpus cavernosum in rabbits
Kilicarslan, Hakan; Bagcivan, Ihsan; Yildirim, M. Kemal; Sarac, Bulent; Kaya, Tijen (BLACKWELL PUBLISHING, 2006)Introduction. The incidence of hormonal dysfunction as a cause of impotence remains controversial. However, several recent studies have reported evidence of hormonal abnormalities in 25-35% of impotent men. Hypothyroidism ... -
The effect of sildenafil on the altered thoracic aorta smooth muscle responses in rat pre-eclampsia model
Turgut, Nergiz Hacer; Temiz, Tijen Kaya; Bagcivan, Ihsan; Turgut, Butent; Gulturk, Sefa; Karadas, Baris (ELSEVIER SCIENCE BV, 2008)The pathophysiology of pre-eclampsia is still unknown thus effective primary prevention is not possible at the stage. The present study was conducted to research the smooth muscle responses in the pre-eclampsia model with ... -
Effects and Selectivity of CL 316243, Beta-3-Adrenoceptor Agonist, in Term-Pregnant Rat Myometrium
Kaya, Tijen; Karadas, Baris; Altun, Ahmet; Sarac, Ikram; Bagcivan, Ihsan (KARGER, 2012)Background/Aims: Recent evidence supports a predominant role of beta(3)-adrenoceptors at the end of pregnancy in myometrium. This study was designed to characterize the pharmacology of the selective beta(3)-adrenoceptor ... -
Effects of alpha 2-adrenoceptor agonists dexmedetomidine and guanfacine on morphine analgesia and tolerance in rats
Gursoy, Sinan; Ozdemir, Ercan; Bagcivan, Ihsan; Altun, Ahmet; Durmus, Nedim (TAYLOR & FRANCIS LTD, 2011)Background. Alpha 2 (alpha(2))-adrenoceptor agonists may be useful for their potential to increase or prolong opioid analgesia while attenuating the development of opioid tolerance. The purpose of this study was to investigate ... -
Effects of Cannabinoid Agonists on Sheep Sphincter of Oddi in vitro
Sarac, Bulent; Durmus, Nedim; Altun, Ahmet; Turan, Mustafa; Kaya, Tijen; Sencan, Mehmet; Bagcivan, Ihsan (ELSEVIER SCIENCE BV, 2011)Background/Aims: According to recent studies, the endocannabinoid system plays an important role in both physiological and pathophysiological situations. The purpose of the present study was to investigate the effects of ... -
The effects of endocannabinoid receptor agonist anandamide and antagonist rimonabant on opioid analgesia and tolerance in rats
Altun, Ahmet; Ozdemir, Ercan; Yildirim, Kemal; Gursoy, Sinan; Durmus, Nedim; Bagcivan, Ihsan (GENERAL PHYSIOL AND BIOPHYSICS, 2015)The role of the cannabinoid (CB) system in the tolerance to analgesic effect of opioid remains obscure. The aim of the present study was to evaluate the effects of the endocannabinoid nonselective receptor agonist anandamide ... -
Effects of formoterol and BRL 37344 on human umbilical arteries in vitro in normotensive and pre-eclamptic pregnancy
Karadas, Baris; Kaya, Tijen; Cetin, Meral; Parlak, Ahmet; Durmus, Nedim; Bagcivan, Ihsan; Gulturk, Sefa (ELSEVIER SCIENCE INC, 2007)Alterations in vascular responses to beta-adrenoceptor agonists in normotensive pregnancy and pre-eclampsia are not fully understood. Thus, we studied changes in vasodilator responses to beta(2)-adrenoceptor agonist ... -
Effects of intravenous anesthetics on the human radial artery used as a coronary artery bypass graft
Gursoy, Sinan; Berkan, Ocal; Bagcivan, Ihsan; Kaya, Tijen; Yildirim, Kemal; Mimaroglu, Caner (W B SAUNDERS CO-ELSEVIER INC, 2007)Objective: Intravenous anesthetics are often used for anesthesia, sedation, and analgesia in the intraoperative and postoperative periods of coronary artery bypass graft (CABG) surgery. This study was designed to investigate ... -
Effects of NO/L-Arginine Pathway on Gallbladder Contractility in Bile Duct Ligated Guinea Pigs
Soylu, Sinan; Aydin, Cengiz; Bagcivan, Ihsan; Yildirim, Sahin; Koyuncu, Ayhan; Topcu, Omer; Arici, Sema (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2009)Background. Common bile duct ligation (CBDL) produces gallbladder distension and acute inflammation similar to that seen in human acute acalculous cholecystitis. CBDL in the guinea pig affects smooth muscle contractility. ... -
Effects of Proton Pump Inhibitors and H-2 Receptor Antagonists on the Ileum Motility
Kurt, Atilla; Altun, Ahmet; Bagcivan, Ihsan; Koyuncu, Ayhan; Topcu, Omer; Aydin, Cengiz; Kaya, Tijen (HINDAWI PUBLISHING CORPORATION, 2011)Objectives. To investigate the effects of proton pump inhibitors (PPIs) and H-2 receptor antagonists on ileum motility in rats with peritonitis and compare changes with control group rats. Methods. Peritonitis was induced ... -
The effects of serotonin/norepinephrine reuptake inhibitors and serotonin receptor agonist on morphine analgesia and tolerance in rats
Ozdemir, Ercan; Gursoy, Sinan; Bagcivan, Ihsan (SPRINGER TOKYO, 2012)Several studies have demonstrated that serotonergic and noradrenergic systems have important roles in morphine analgesia and tolerance. However, the exact mechanism underlying the development of morphine tolerance is not ...