Browsing Makale Koleksiyonu by Author "Kacan, Turgut"
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Could the Neutrophil to Lymphocyte Ratio be a Poor Prognostic Factor for Non Small Cell Lung Cancers?
Kacan, Turgut; Babacan, Nalan Akgul; Seker, Metin; Yucel, Birsen; Bahceci, Aykut; Eren, Ayfer Ay; Eren, Mehmet Fuat; Kilickap, Saadettin (ASIAN PACIFIC ORGANIZATION CANCER PREVENTION, 2014)Background: Although many prognostic factors have been identified for lung cancers, new ones are needed to determine the course of the disease. Recently, a high neutrophil to lymphocyte ratio (NLR) prior to surgery or ... -
Effect of imatinib on growth of experimental endometriosis in rats
Yildiz, Caglar; Kacan, Turgut; Akkar, Ozlem Bozoklu; Karakus, Savas; Seker, Metin; Kacan, Selen Baloglu; Ozer, Hatice; Cetin, Ali (ELSEVIER SCIENCE BV, 2016)Objective: Currently, medical and surgical treatment options for endometriosis are limited due to suboptimal efficacy, and also safety and tolerance issues. Long-term use of gonadotrophin-releasing hormone analogs, androgenes, ... -
The effect of the gastrectomy on survival in patients with metastatic gastric cancer: a study of ASMO
Yazici, Ozan; Ozdemir, Nuriye; Duran, Ayse Ocak; Menekse, Serkan; Ali, Mehmet; Sendur, Nahit; Karaca, Halit; Goksel, Gamze; Arpaci, Erkan; Hacibekiroglu, Ilhan; Bilgetekin, Irem; Kacan, Turgut; Ozkan, Metin; Aksoy, Sercan; Aksoy, Asude; Cokmert, Suna; Uysal, Mukremin; Elkiran, Emin Tamer; Cicin, Irfan; Buyukberber, Suleyman; Zengin, Nurullah (FUTURE MEDICINE LTD, 2016)Aim: To investigate the role of surgical resection of primary tumor on overall survival (OS) in advanced gastric cancer patients at the time of diagnosis. Patients & methods: The survival rates of metastatic gastric cancer ... -
Effects of Pazopanib, Sunitinib, and Sorafenib, Anti-VEGF Agents, on the Growth of Experimental Endometriosis in Rats
Yildiz, Caglar; Kacan, Turgut; Akkar, Ozlem Bozoklu; Karakus, Savas; Kacan, Selen Baloglu; Ozer, Hatice; Cetin, Ali (SAGE PUBLICATIONS INC, 2015)We aimed to compare the effects of pazopanib, sunitinib, and sorafenib on endometriotic tissue morphology and histological characteristics as well as ovarian reserve in a rat model. Experimental endometriosis was established ... -
Investigation of Antitumor Effects of Sorafenib and Lapatinib Alone and in Combination on MCF-7 Breast Cancer Cells
Kacan, Turgut; Altun, Ahmet; Altun, Gulsah Gultekin; Kacan, Selen Baloglu; Sarac, Bulent; Seker, Mehmet Metin; Bahceci, Aykut; Babacan, Nalan (ASIAN PACIFIC ORGANIZATION CANCER PREVENTION, 2014)Background: Breast cancer evolution and tumor progression are controlled by complex interactions between steroid receptors and growth factor receptor signaling. Aberrant growth factor receptor signaling can augment or ... -
Is there a relation between Murine double minute 2 T309G polymorphism and lung cancer risk in the Turkish population?
Yilmaz, Meral; Tas, Ayca; Kacan, Turgut; Sari, Musa; Silig, Yavuz (WALTER DE GRUYTER GMBH, 2017)Introduction: Association between Murine double minute 2 T309G polymorphism and lung cancer risk has been investigated in several populations, but results of these studies are inconsistent. We aimed to investigate the ... -
Lack of Association between the MTHFR C677T Polymorphism and Lung Cancer in a Turkish Population
Yilmaz, Meral; Kacan, Turgut; Sari, Ismail; Kilickap, Saadettin (ASIAN PACIFIC ORGANIZATION CANCER PREVENTION, 2014)Background: In this case-control study, we aimed to investigate the relationship between the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and lung cancer. Materials and Methods: Total 200 individuals ... -
The mean platelet volume may predict the development of isolated bone metastases in patients with breast cancer: a retrospective study of the Young Researchers Committee of the Turkish Oncology Group (TOG)
Tanriverdi, Ozgur; Menekse, Serkan; Teker, Fatih; Oktay, Esin; Pilanci, Kezban Nur; Gunaldi, Meral; Kocar, Muharrem; Kacan, Turgut; Bahceci, Aykut; Avci, Nilufer; Akman, Tulay; Cokmert, Suna; Yesil-Cinkir, Havva; Yanmaz, Mustafa Teoman (ZERBINIS MEDICAL PUBL, 2016)Purpose: To determine the predictive value of the mean platelet volume (MPV) and the MPV/platelet count ratio on the development of isolated bone metastasis in patients with breast cancer. Methods: A total of 121 previously ... -
Multicenter Epidemiologic Study on Hepatocellular Carcinoma in Turkey
Can, Alper; Dogan, Erkan; Bayoglu, Ibrahim Vedat; Tatli, Ali Murat; Besiroglu, Mehmet; Kocer, Murat; Dulger, Ahmet Cumhur; Uyeturk, Ummugul; Kivrak, Derya; Orakci, Zuat; Bal, Oznur; Kacan, Turgut; Olmez, Sehmus; Turan, Nedim; Ozbay, Mehmet Fatih; Alacacioglu, Ahmet (ASIAN PACIFIC ORGANIZATION CANCER PREVENTION, 2014)Background: Hepatocellular cancer (HCC) is one of the important health problems in Turkey, being very common and highly lethal. The aim of this study was to determine clinical, demographic features and risk factors. Materials ... -
Oxaliplatin and ototoxicity: is it really safe for hearing?
Yuce, Salim; Seker, Mehmet Metin; Koc, Sema; Uysal, Ismail Onder; Kacan, Turgut; Dogan, Mehtap; Dogan, Mansur; Babacan, Nalan Akgul; Kilickap, Saadettin (TUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEY, 2014)Background/aim: Oxaliplatin is an effective and widely used chemotherapeutic agent in the treatment of many solid tumors. The most common side effects are peripheral neuropathy, gastrointestinal toxicity, and neutropenia. ... -
Potential Impact of Atelectasis and Primary Tumor Glycolysis on F-18 FDG PET/CT on Survival in Lung Cancer Patients
Hasbek, Zekiye; Yucel, Birsen; Salk, Ismail; Turgut, Bulent; Erselcan, Taner; Babacan, Nalan Akgul; Kacan, Turgut (ASIAN PACIFIC ORGANIZATION CANCER PREVENTION, 2014)Background: Atelectasis is an important prognostic factor that can cause pleuritic chest pain, coughing or dyspnea, and even may be a cause of death. In this study, we aimed to investigate the potential impact of atelectasis ... -
The Prognostic Value of High Pretreatment Plasma D-Dimer Levels in Non-Metastatic Breast Cancer Patients with Absence of Venous Thromboembolism
Kacan, Turgut; Yucel, Birsen; Bahar, Seher; Celasun, Gurol; Seker, Mehmet M.; Babacan, Nalan; Bahceci, Aykut; Kacan, Selen B.; Kilickap, Saadettin (AKAD DOKTORLAR YAYINEVI, 2016)Systemic activation of coagulation and fibrinolysis is frequently observed in cancer patients without thrombosis. Recent studies have showed the association between D-Dimer (DD) and metastatic spread and prognosis of cancer. ... -
The prognostic value of UHRF-1 and p53 in gastric cancer
Babacan, Nalan A.; Egilmez, Hatice Reyhan; Yucel, Birsen; Parlak, Ilknur; Seker, Mehmet Metin; Kacan, Turgut; Bahceci, Aykut; Cihan, Sener; Akinci, Bulent; Eriten, Berna; Kilickap, Saadettin (MEDKNOW PUBLICATIONS & MEDIA PVT LTD, 2016)Background/Aims: This study aimed to examine whether UHRF-1 and p53 overexpression is a prognostic marker for gastric cancer. Patients and Methods: Sixty-four patients with gastric cancer (study group) and 23 patients with ... -
The Relationship of Agmatine Deficiency with the Lung Cancer
Kapancik, Serkan; Celik, V. Kenan; Kilickap, Saadettin; Kacan, Turgut; Kapancik, Sercan (AKAD DOKTORLAR YAYINEVI, 2016)The polyamines are essential for rapidly growing cells. Polyamines is synthesized by two reactions which begin from arginine. The aim of this study is to examine the serum levels of the enzymes located in the putrescine ... -
Retrospective analysis of the microbiological spectrum of pneumonia in Turkish patients with lung cancer
Avci, Nilufer; Hartavi, Mustafa; Kacan, Turgut; Bayindir, Murat; Avci, Mustafa; Ozakin, Cuneyt; Engin, Aynur; Deliqonull, Adem; Evrensel, Turkkan; Akalin, Halis (TERMEDIA PUBLISHING HOUSE LTD, 2016)Aim of the study: The spectrum of pulmonary infections in patients with lung cancer is wide, and tools for target-oriented infection control measures are necessary. In this retrospective study we report the microbiological ... -
Serum levels of polyamine synthesis enzymes increase in diabetic patients with breast cancer
Celik, V. Kenan; Kapancik, Sercan; Kacan, Turgut; Kacan, Selen Baloglu; Kapancik, Serkan; Kilicgun, Hasan (BIOSCIENTIFICA LTD, 2017)Background: In this study, it was aimed to investigate the relationship between diabetes and breast cancer and the detection of enzymes and ornithine levels in polyamine synthesis pathway in diabetes, breast cancer and ... -
Significant Association Between Polymorphisms of Wnt Antagonist Genes and Lung Cancer
Yilmaz, Meral; Donmez, Gonca; Kacan, Turgut; Sari, Ismail; Babacan, Nalan Akgul; Sari, Musa; Kilickap, Saadettin (BMJ PUBLISHING GROUP, 2015)Further elucidation of the molecular mechanisms underlying lung cancer (LC) is essential for the development of new effective therapeutic agents. Recently, involvement of Wnt antagonists in oncogenesis has been demonstrated ... -
Survival Analysis and Prognostic Factors for Neuroendocrine Tumors in Turkey
Yucel, Birsen; Babacan, Nalan Akgul; Kacan, Turgut; Eren, Ayfer Ay; Eren, Mehmet Fuat; Bahar, Seher; Celasun, Mustafa Gurol; Seker, Mehmet Metin; Hasbek, Zekiye (ASIAN PACIFIC ORGANIZATION CANCER PREVENTION, 2013)Background: This study aimed to determine the demographical distribution, survival and prognostic factors for neuroendocrine tumors monitored in our clinic. Materials and Methods: Data for 52 patients who were admitted to ... -
Therapeutic and prophylactic effects of strontium on radiotherapy-induced skin toxicity in rats
Yucel, Birsen; Hayta, Sibel Berksoy; Goze, Omer Fahrettin; Erdis, Eda; Bahar, Seher; Celasun, Mustafa Gurol; Kacan, Turgut; Akyol, Melih (TURKISH SOC DERMATOLOGY VENEROLOGY, 2017)Background and Design: This study aimed to investigate whether 5% strontium (Sr) chloride hexahydrate has preventive or therapeutic effects on the radiotherapy (RT)-induced adverse skin effects. Materials and Methods: ...