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Designing phase 3 sepsis trials: application of learned experiences from critical care trials in acute heart failure

Mebazaa, Alexandre; Laterre, Pierre Francois; Russell, James A.; Bergmann, Andreas; Gattinoni, Luciano; Gayat, Etienne; Harhay, Michael O.; Hartmann, Oliver; Hein, Frauke; Kjolbye, Anne Louise; Legrand, Matthieu; Lewis, Roger J.; Marshall, John C.; Marx, Gernot; Radermacher, Peter; Schroedter, Mathias; Scigalla, Paul; Stough, Wendy Gattis; Struck, Joachim; Van den Berghe, Greet; Yilmaz, Mehmet Birhan; Angus, Derek C. (BMC, 2016)

Substantial attention and resources have been directed to improving outcomes of patients with critical illnesses, in particular sepsis, but all recent clinical trials testing various interventions or strategies have failed ...

Letter to editor: Clinical profile and predictors of in-hospital outcome in patients with heart failure

Ege, Meltem Refiker; Yucel, Oguzhan; Zorlu, Ali; Yilmaz, Mehmet Birhan (ELSEVIER IRELAND LTD, 2011)

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Association of right heart with CA-125 levels in patients with heart failure

Refiker, Meltem; Yilmaz, Mehmet Birhan (ELSEVIER IRELAND LTD, 2010)

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Levosimendan beyond inotropy and acute heart failure: Evidence of pleiotropic effects on the heart and other organs: An expert panel position paper

Farmakis, Dimitrios; Alvarez, Julian; Ben Gal, Tuvia; Brito, Dulce; Fedele, Francesco; Fonseca, Candida; Gordon, Anthony C.; Gotsman, Israel; Grossini, Elena; Guarracino, Fabio; Harjola, Veli-Pekka; Hellman, Yaron; Heunks, Leo; Ivancan, Visnja; Karavidas, Apostolos; Kivikko, Matti; Lomivorotov, Vladimir; Longrois, Dan; Masip, Josep; Metra, Marco; Morelli, Andrea; Nikolaou, Maria; Papp, Zoltan; Parkhomenko, Alexander; Poelzl, Gerhard; Pollesello, Piero; Ravn, Hanne Berg; Rex, Steffen; Riha, Hynek; Ricksten, Sven-Erik; Schwinger, Robert H. G.; Vrtovec, Bojan; Yilmaz, M. Birhan; Zielinska, Marzenna; Parissis, John (ELSEVIER IRELAND LTD, 2016)

Levosimendan is a positive inotrope with vasodilating properties (inodilator) indicated for decompensated heart failure (HF) patients with low cardiac output. Accumulated evidence supports several pleiotropic effects of ...

Depression and heart failure

Ege, Meltem Refiker; Yilmaz, Nuryil; Yilmaz, Mehmet Birhan (ELSEVIER IRELAND LTD, 2012)

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CA125 in heart failure: Implications for immunoinflammatory activity

Turgut, Okan; Tandogan, Izzet; Yilmaz, Mehmet Birhan; Gul, Ibrahim; Zorlu, Ali (ELSEVIER IRELAND LTD, 2011)

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Acute heart failure and cardiogenic shock: a multidisciplinary practical guidance

Mebazaa, A.; Tolppanen, H.; Mueller, C.; Lassus, J.; DiSomma, S.; Baksyte, G.; Cecconi, M.; Choi, D. J.; Solal, A. Cohen; Christ, M.; Masip, J.; Arrigo, M.; Nouira, S.; Ojji, D.; Peacock, F.; Richards, M.; Sato, N.; Sliwa, K.; Spinar, J.; Thiele, H.; Yilmaz, M. B.; Januzzi, J. (SPRINGER, 2016)

Purpose: Acute heart failure (AHF) causes high burden of mortality, morbidity, and repeated hospitalizations worldwide. This guidance paper describes the tailored treatment approaches of different clinical scenarios of AHF ...

Tumour biomarkers in heart failure: is there a role for CA-125?

Yilmaz, Mehmet Birhan; Nikolaou, Maria; Solal, Alain Cohen (WILEY, 2011)

Tumour markers are used for the screening, diagnosis, and stratification of cancer disease. Recently, the potential role of some tumour markers has also been explored in the context of heart failure. These include CA-125, ...

Organ dysfunction, injury and failure in acute heart failure: from pathophysiology to diagnosis and management. A review on behalf of the Acute Heart Failure Committee of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC)

Harjola, Veli-Pekka; Mullens, Wilfried; Banaszewski, Marek; Bauersachs, Johann; Brunner-La Rocca, Hans-Peter; Chioncel, Ovidiu; Collins, Sean P.; Doehner, Wolfram; Filippatos, Gerasimos S.; Flammer, Andreas J.; Fuhrmann, Valentin; Lainscak, Mitja; Lassus, Johan; Legrand, Matthieu; Masip, Josep; Mueller, Christian; Papp, Zoltan; Parissis, John; Platz, Elke; Rudiger, Alain; Ruschitzka, Frank; Schaefer, Andreas; Seferovic, Petar M.; Skouri, Hadi; Yilmaz, Mehmet Birhan; Mebazaa, Alexandre (WILEY, 2017)

Organ injury and impairment are commonly observed in patients with acute heart failure (AHF), and congestion is an essential pathophysiological mechanism of impaired organ function. Congestion is the predominant clinical ...

CA125 levels among patients with advanced heart failure: An emerging independent predictor for survival

Turgut, Okan; Tandogan, Izzet; Yilmaz, Mehmet Birhan; Gul, Ibrahim; Gurlek, Ahmet (ELSEVIER IRELAND LTD, 2010)

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