Browsing Temel Eczacılık Bilimleri Bölümü Makale Koleksiyonu by Author "284ecb9f-1b1c-4d3b-b993-b2a4ce5258cb"
Now showing items 1-11 of 11
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ALLYL FUNCTIONALIZED BENZIMIDAZOLIUM-DERIVED AG(I)-N-HETEROCYCLIC CARBENE COMPLEXES: ANTI-BIOFILM AND ANTIMICROBIAL PROPERTIES
TUTAR, UĞUR; Çelik, Cem; Şahin, Neslihan (April, 202)Microorganisms in the biofilm structure cause severe health problems and economic losses. Therefore, it is very important to design and screen anti-biofilm molecules that can solve the related problems. This paper is aimed ... -
Antimicrobial activity, inhibition of biofilm formation, and molecular docking study of novel Ag-NHC complexes
TUTAR, UĞUR; ŞAHİN, NESLİHAN; ÜSTÜN, ELVAN; ÇELİK, CEM; GÜRBÜZ, NEVİN; ÖZDEMİR, İSMAİL (ELSEVİER, 2021)In this study, we reported the synthesis of a new series of Silver(I)-N-heterocyclic carbene complexes which were obtained from the corresponding new N-heterocyclic carbene (NHC) precursors. All new compounds were ... -
Antimicrobial and antibiofilm activities and bovine serum albumin binding properties of benzimidazolium derivative NHC salts and their Ag(I)-NHC complexes
Çelik, Cem; Üstün, Elvan; Şahin, Neslihan; Tutar, Uğur (December 2)Benzimidazole type N-heterocyclic carbene molecules and their metal complexes have well-known biological activity. Elemental silver and silver complexes also have antibacterial and antifungal activity. In this study, ... -
Antimicrobial, anti-biofilm and cytotoxic properties of methallyl functionalized benzimidazolium-derived Ag(I)-Nheterocyclic carbene complexes
Çelik, Cem; Tutar, Uğur; Şahin, Neslihan; Öztürk, Ayşegül (April 2022)Purpose: To investigate the antimicrobial, antibiofilm, and cytotoxicity properties of methallyl substituted benzimidazolium-based, silver-bound N-heterocyclic carbene (Ag(I)-NHC) complexes, with respect to their potential ... -
Benzimidazol-2-ylidene Silver Complexes: Synthesis, Characterization, Antimicrobial and Antibiofilm Activities, Molecular Docking and Theoretical Investigations
TUTAR, UĞUR; Çelik, Cem; ÜSTÜN, ELVAN; ÖZDEMİR, NAMIK; Şahin, Neslihan; DAVID, SEMERIL; Gürbüz, Nevin; Özdemir, İsmail (EYLÜL 2023)Abstract: Five silver(I) complexes, namely chloro[1-methallyl-3-benzyl)benzimidazol-2-ylidene] silver (6), chloro[1-methallyl-3-(2,3,5,6-tetramethylbenzyl)benzimidazol-2-ylidene]silver (7), chloro[1- methallyl-3-(3,4,5 ... -
Cytotoxic, Antioxidant, Antibiofilm, and Antimicrobial Activities of Mushroom Species from Turkey
DİNÇER, EMİNE; IŞIK, HAKAN; Hepokur, Ceylan; TUTAR, UĞUR; Çelik, Cem (HAZİRAN 20)ABSTRACT: Mushrooms, which have been collected to meet the nutritional needs of the world for many years, have gained medical importance thanks to the bioactive compounds they produce. Thanks to studies carried out to ... -
Investigation of the Antimicrobial Agent Potential of 1,5-diketon Derivatives
TUTAR, UĞUR; GEZEGEN, HAYREDDİN; KORKMAZ, GÜRSEL (2021)In this study 1,5-diketones were synthesized by adding of cyclohexzanone to five differtent calcone derivatives (1a-e) via di-1,4-Michael addition reaction. As a result the compounds with the best activity were 3a, 3b and ... -
Michael/Michael Addition Cascade of 2-Benzylidene-1- indanones with Chalcones: Synthesis and Biological Evaluations of Novel Polycyclic Compounds
TUTAR, UĞUR; GEZEGEN, HAYREDDİN; CEYLAN, HEPOKUR; TÜZÜN, GAMZE; ATİOĞLU, ZELİHA; AKKURT, MEHMET (WİLLEY ONLİNE LİBRARY, 2021)A series of novel racemic 2-aryloyl-1,3-diaryl-2,3,3a,8a-tetrahydrocyclopenta[ a]inden-8(1H)-one derivatives were synthesized from KOtBu mediated Michael/Michael addition reaction of 2- benzylidene-1-indanones with ... -
Michael/Michael Addition Cascade of 2-Benzylidene-1- indanones with Chalcones: Synthesis and Biological Evaluations of Novel Polycyclic Compounds
Gezegen,Hayreddin; Tutar, Uğur; Hepokur, Ceylan; Tüzün, Gamze; Atioğlu,Zeliha; Akkurt, Mehmet (2021)A series of novel racemic 2-aryloyl-1,3-diaryl-2,3,3a,8a-tetrahy drocyclopenta[a]inden-8(1H)-one derivatives were synthesized from KOtBu mediated Michael/Michael addition reaction of 2- benzylidene-1-indanones with ... -
Synthesis of Bis-Nicotinonitrile Derivatives and Investigations of Antimicrobial and Antibiofilm Activities
TUTAR, UĞUR; Gezegen, Hayreddin (Ekim 2023)In this study aimed to the synthesis of novel bis-nicotinonitrile derivatives starting from 1,3-bis-chalcones and investigate their antimicrobial activity potentials. Bis-nicotinonitrile derivatives were synthesized from ... -
Synthesis, characterization, antimicrobial and antibiofilm activity, and molecular docking analysis of NHC precursors and their Ag-NHC complexes†
TUTAR, UĞUR; ÜSTÜN, ELVAN; ŞAHİN, NESLİHAN; ÇELİK, CEM; ÖZDEMİR, NAMIK; GÜRBÜZ, NEVİN; ÖZDEMİR, İSMAİL (The Royal Society, 2021)Microorganisms attach to surfaces and interfaces and form biofilms which create a sheltered area for host cell response. Therefore, biofilms provide troubles in fields such as medicine, food, and pharmaceuticals. Inhibition ...