Browsing Temel Eczacılık Bilimleri Bölümü Makale Koleksiyonu by Author "46caa766-2946-4b50-b5a7-25dbbfde36bd"
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A new method for synthesis of carbon nanoparticle and its applications
In the present study, we synthesized carbon nanoparticles with a different method using chi tosan, a natural polymer. As a result, carbon nanomaterials were diffused directly through the intestinal membrane, and carbon ... -
circRNAs in drug resistance of breast cancer
Mısır, Sema; YAMAN, SERAP OZER; PETROVIĆ,NINA; SUMER,CEREN; HEPOKUR, CEYLAN; ALIYAZICIOGLU,YUKSEL (2022)Abstract: Breast cancer (BC) is the most common heterogeneous disease in women and one of the leading causes of cancer-related death. Surgery, chemotherapy, radiotherapy, hormone, and targeted therapy are the gold standards ... -
Circulating serum miR-200c and miR-34a-5p as diagnostic biomarkers for endometriosis
Misir, Sema; Hepokur, Ceylan; Oksasoglu, Bugra; Yildiz, Caglar; Yanik, Ali; Aliyazicioglu,Yüksel (2021)Objective: Endometriosis is defined by the presence of endometrial glands and stroma grow in areas outside the uterus. A simple blood test for endometriosis-specific biomarkers would offer a more timely accurate diagnosis ... -
Design, synthesis and biological evaluation of novel bischalcone derivatives as potential anticancer agents
Burmalıoğlu Serdar; Göbek, Arzu; Özturk Aydın,Busra; Yurtoğlu, Emine; Nur Aydın,Busra; Yalcin Ozkat,Gozde; Hepokur, Ceylan; Şimşek Özek, Nihal; Ayşin, Ferhunde; Altundas, Ramazan; Algul,Oztekin (1April 202)Building on our previous work that discovered chalcone as a promising pharmacophore for anticancer activity, we have various other chalcone derivatives and have synthesized a series of novel bischalcone to explore their ... -
Design, synthesis and in vitro antiproliferation activity of some 2-aryl and -heteroaryl benzoxazole derivatives
Background: Phortress produces reactive electrophilic metabolites that form DNA adducts only in sensitive tumor cells. The authors converted the 2-phenylbenzothiazole nucleus in phortress to 2- aryl and -heteroaryl ... -
Evaluation of the effects of newly synthesized metallophthalocyanines on breast cancer cell lines with photodynamic therapy
Bostancı, Hayrani Eren; Bilgiçli, Ahmet Turgut; Güzel, Emre; Günsel, Armağan; Hepokur, Ceylan; Çimen, Behzat; Yaraşır, Meryem Nilüfer (Royal Society of Chemistry, 21.09.2022)In this study, the new phthalonitrile derivative 3-(4-(3-oxobutyl)phenoxy)phthalonitrile (1) and its nonperipheral metallophthalocyanine derivatives [zinc (2), copper (3), cobalt (4), manganese (5), gallium (6), and ... -
Michael/Michael Addition Cascade of 2-Benzylidene-1- indanones with Chalcones: Synthesis and Biological Evaluations of Novel Polycyclic Compounds
Gezegen,Hayreddin; Tutar, Uğur; Hepokur, Ceylan; Tüzün, Gamze; Atioğlu,Zeliha; Akkurt, Mehmet (2021)A series of novel racemic 2-aryloyl-1,3-diaryl-2,3,3a,8a-tetrahy drocyclopenta[a]inden-8(1H)-one derivatives were synthesized from KOtBu mediated Michael/Michael addition reaction of 2- benzylidene-1-indanones with ... -
Possible effects of clinoptilolite on small intestinal ischemia-reperfusion injury caused by experimental mesenteric artery occlusion
Objectives: Mesenteric ischemia is a surgical emergency caused by poor blood supply to the intestines. In ischemia,the decrease in blood flow to the tissue causes acidosis and cell death through anaerobic metabolism. ... -
Potential role of immune cell genetic variants associated with tumor microenvironment response in laryngeal squamous cell carcinoma (LSCC) in terms of clinicopathological features
Horozoglu,Cem; Sonmez, Dilara; Demirkol, Seyda; Hakan, Mehmet Tolgahan; Hepokur, Ceylan; Verim, Aysegul; Yaylim, Ilhan (20 October)Immunomodulatory signals regulate the self-tolerance, activation, priming and survival processes of T cells. Programmed cell death protein 1 (PD1), Programmed death-ligand 1 (PD-L1) inhibitory signals and CD27, CD28 ... -
Selective cytotoxicity of paclitaxel bonded silver nanoparticle on different cancer cells
Paclitaxel (PTX) is one of the most effective drugs in the treatment of cancer. However, its usability is limited due to low solubility and side effects. In this study, we investigated anticancer effects of PTX bonded ... -
Synthesis of New 1-Aryl-2-(3,5-dimethylpyrazol-1-yl)ethanone Oxime Ether Derivatives and Investigation of Their Cytotoxic Effects
Alagöz,Mehmet Abdullah; Karakurt,Arzu; Hepokur, Ceylan; Salva, Emine; Önkol, Tijen; Ghoneim, Mohammed M.; Abdelgawad, Mohamed A.; Khames, Ahmed; Kim,Hoon; Mathew,Bijo (2021): In this study, 12 new 1-aryl-2-(3,5-dimethylpyrazol-1-yl)ethanone oxime ether derivatives were designed and synthesized to investigate their cytotoxic effects. The in vitro cytotoxic activities of the compounds were ... -
Synthesis, Biological Evaluation and In Silico Studies of Some 2‐Substituted Benzoxazole Derivatives as Potential Anticancer Agents to Breast Cancer
In an attempt to develop potent and selective anticancer agents, some 5- or 6- and N-substituted benzoxazol-2-carbox amide derivatives were designed, synthesized, and evaluated for their cyclooxygenase inhibitory, antioxidant, ... -
Tetra-substituted phthalocyanines bearing thiazolidine derivatives: synthesis, anticancer activity on different cancer cell lines, and molecular docking studies
Bilgiçli, Ahmet T.; Hepokur, Ceylan; Genc Bilgicli, Hayriye; Tüzün, Burak; Mısır, Sema; Zengina, Mustafa; Yarasir, M. Nilüfer; Günsel, Armağan (2021)In the first step, (4R)-2-(2-hydroxyphenyl)thiazolidine-4-carboxylic acid (c) and 2-(2-(3,4-dicyano phenoxy)phenyl)thiazolidine-4-carboxylic acid (1) were prepared. Then, the peripherally tetra-substituted metallophthalocyanines ... -
The role of cytokeratin 19 levels in the determination of endometriosis stages
Objective/Aim: Endometrisosis, one of the most common gynecological disease, is characterized by the presence of endometriotic tissue outside of uterine cavity. The development and the validation of a simple blood ...