Browsing Temel Eczacılık Bilimleri Bölümü Makale Koleksiyonu by Author "Eczacılık Fakültesi"
Now showing items 1-20 of 88
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1, 2, 3-Triazole substituted phthalocyanine metal complexes as potential inhibitors for anticholinesterase and antidiabetic enzymes with molecular docking studies
Koçyiğit,Ümit M.; Taslimi, Parham; Tüzün,Burak; Yakan,Hasan; Muğlu, Halit; Güzel,Emre (Taylor & Francis, 2022/01/26)In recent years, acetylcholinesterase (AChE) and α-glycosidase (α-gly) inhibition have emerged as a promising and important approach for pharmacological intervention in many diseases such as glaucoma, epilepsy, obesity, ... -
A new method for synthesis of carbon nanoparticle and its applications
In the present study, we synthesized carbon nanoparticles with a different method using chi tosan, a natural polymer. As a result, carbon nanomaterials were diffused directly through the intestinal membrane, and carbon ... -
ALLYL FUNCTIONALIZED BENZIMIDAZOLIUM-DERIVED AG(I)-N-HETEROCYCLIC CARBENE COMPLEXES: ANTI-BIOFILM AND ANTIMICROBIAL PROPERTIES
TUTAR, UĞUR; Çelik, Cem; Şahin, Neslihan (April, 202)Microorganisms in the biofilm structure cause severe health problems and economic losses. Therefore, it is very important to design and screen anti-biofilm molecules that can solve the related problems. This paper is aimed ... -
Antimicrobial activity, inhibition of biofilm formation, and molecular docking study of novel Ag-NHC complexes
TUTAR, UĞUR; ŞAHİN, NESLİHAN; ÜSTÜN, ELVAN; ÇELİK, CEM; GÜRBÜZ, NEVİN; ÖZDEMİR, İSMAİL (ELSEVİER, 2021)In this study, we reported the synthesis of a new series of Silver(I)-N-heterocyclic carbene complexes which were obtained from the corresponding new N-heterocyclic carbene (NHC) precursors. All new compounds were ... -
Antimicrobial and antibiofilm activities and bovine serum albumin binding properties of benzimidazolium derivative NHC salts and their Ag(I)-NHC complexes
Çelik, Cem; Üstün, Elvan; Şahin, Neslihan; Tutar, Uğur (December 2)Benzimidazole type N-heterocyclic carbene molecules and their metal complexes have well-known biological activity. Elemental silver and silver complexes also have antibacterial and antifungal activity. In this study, ... -
Antimicrobial, anti-biofilm and cytotoxic properties of methallyl functionalized benzimidazolium-derived Ag(I)-Nheterocyclic carbene complexes
Çelik, Cem; Tutar, Uğur; Şahin, Neslihan; Öztürk, Ayşegül (April 2022)Purpose: To investigate the antimicrobial, antibiofilm, and cytotoxicity properties of methallyl substituted benzimidazolium-based, silver-bound N-heterocyclic carbene (Ag(I)-NHC) complexes, with respect to their potential ... -
Application of cloud point extraction for residues of chloramphenicol and amoxicillin in milk samples by HPLC–DAD
Sürücü, Bilge; Ulusoy, Halil İbrahim; Ulusoy, Songül; Demir, Özge; Gülle, Sümeyra (Springer, 2022)A pre-concentration and sensitive determination method for residues of Chloramphenicol (CLP) and Amoxicillin (AMX) in milk samples were developed based on cloud point extraction (CPE) and HPLC–DAD analysis. CLP and AMX ... -
Application of magnetic solid‑phase extraction for sensitive determination of anticancer drugs in urine by means of diamino benzidine tetrachlorohydrate modified magnetic nanoparticles
Emin AKYOL; Halil İbrahim ULUSOY; Erkan YILMAZ; Ümmügülsüm POLAT; Mustafa SOYLAK (Springer, 25 Februar)Background The analysis of drug active molecules and residues in the treatment of cancer is important for the sustainability of human life and therapeutic effects. For this purpose, a new magnetic sorbent was developed ... -
Application of magnetic solid‑phase extraction for sensitive determination of anticancer drugs in urine by means of diamino benzidine tetrachlorohydrate modified magnetic nanoparticles
Akyol,Emin; Ulusoy,Halil İbrahim; Yilmaz,Erkan; Polat,Ümmügülsüm; Soylak,Mustafa (Şubat, 202)Background The analysis of drug active molecules and residues in the treatment of cancer is important for the sustainability of human life and therapeutic effects. For this purpose, a new magnetic sorbent was developed ... -
Arylated quinoline and tetrahydroquinolines: Synthesis, characterization and their metabolic enzyme inhibitory and antimicrobial activities
Koçyiğit,Ümit M.; Ökten,Salih; Çakmak, Osman; Gizem, Burhan; Ataş,Mehmet; Taslimi, Parham; Gülçin,İlhami (Chemstry Europa, 2022/10/07)The aims of this study are to synthesize and characterize some new phenyl quinoline derivatives and to determine the activities of them and the recently prepared substituted phenyl quinolines against Acetylcholinesterase ... -
Assessing the Antiangiogenic Effects of Chalcones and Their Derivatives
Hepokur ,Ceylan; Serdar, Burmaoglu; Arzu,Gobek; Derya,Aktas Anil; Mehmet ,Abdullah Alagoz; Adem,Guner; Cem, Guler; N. Ulku,Karabay Yavasoglu; Oztekin,Algul (19 Jan 202)Pathological angiogenesis plays a critical role in tumorigenesis and tumor pro gression, and anti-angiogenesis therapies have evinced promising antitumor effects in solid tumors. Chalcone skeleton has been regarded as a ... -
Azinphos-methyl and chlorfenvinphos pesticides determination using fabric phase sorptive extraction followed by high performance liquid chromatography-photodiode array detector
Halil ˙İbrahim Ulusoy; Masoumeh Sattari Dabbagh; Marcello Locatelli; Songül Ulusoy; Abuzar Kabir; Mir Ali Farajzadeh (Elsevier, 25 April 2)A reliable and efficient fabric phase sorptive extraction method was developed for the rapid analysis of azinphosmethyl and chlorfenvinphos pesticide residues in wastewater and fruit juice samples using high-performance liquid ... -
Benzimidazole-hydrazone derivatives: Synthesis, in vitro anticancer, antimicrobial, antioxidant activities, in silico DFT and ADMET studies
Işık, Ayşen; Çevik, Ulviye Acar; Çelik, İsmail; Bostancı, Hayrani Eren; Karayel, Arzu; Gündoğdu, Gülsüm; İnce, Ufuk; Koçak, Ahmet; Özkay, Yusuf; Kaplancıklı, Zafer Asım (Elsevier, 14.08.2022)Based on the biologically active heterocycle compounds, a series of new benzimidazole-hydrazone deriva- tives ( 3a-3j ) were synthesized, starting from 4-(6-chloro-1 H -benzimidazol-2-yl) benzohydrazide. The syn- thesized ... -
Biological effects and molecular docking studies of Catechin 5-O-gallate: Antioxidant, anticholinergics, antiepileptic and antidiabetic potentials
Taslimi, Parham; Koçyiğit,Ümit M.; Tüzün,Burak; Kirici,Mahinur (Taylor & Francis, 2022/04/13)Gallocatechin gallate is a form of catechin and an ester of gallocatechin and gallic acid. This is an epimer of the gallate epigallocatechin. In this study, the effect of this molecule, containing a biologically active ... -
Biologically active phthalocyanine metal complexes: Preparation, evaluation of α‐glycosidase and anticholinesterase enzyme inhibition activities, and molecular docking studies
Güzel,Emre; Koçyiğit,Ümit M.; Taslimi, Parham; Erkan Sultan; Omer,Taskin S. (Wiley-VCH GmbH, Weinheim, 2021/6)In this study, preparation, as well as investigation of α‐glycosidase and cholinesterase (ChE) enzyme inhibition activities of furan‐2‐ylmethoxy‐substituted compounds 1–7, are reported. Peripherally, tetra‐substituted ... -
Biomarker potentials of miRNA‑associated circRNAs in breast cancer (MCF‑7) cells: an in vitro and in silico study
Breast cancer is a heterogeneous disease, which is the most common malignancy in women. The incidence and mortality rates of breast cancer indicate that it is the leading cause of cancer-related with deaths. circRNAs ... -
BSA/DNA binding behavior and the photophysicochemical properties of novel water soluble zinc (II) phthalocyanines directly substituted with piperazine groups
Khezami, Khaoula; Harmandar, Kevser; Bağda, Esra; Bağda, Efkan; Şahin, Gamze; Karakodak, Nurşen; Durmuş, Mahmut (2021/6)In the current research, two novel zinc(II) phthalocyanines (ZnPcs) (1 and 2) directly connecting with 4-(4-methylpiperazin-1-yl)phenyl groups have been synthesized through the Suzuki–Miyaura coupling reaction. These ZnPcs ... -
circRNAs in drug resistance of breast cancer
Mısır, Sema; YAMAN, SERAP OZER; PETROVIĆ,NINA; SUMER,CEREN; HEPOKUR, CEYLAN; ALIYAZICIOGLU,YUKSEL (2022)Abstract: Breast cancer (BC) is the most common heterogeneous disease in women and one of the leading causes of cancer-related death. Surgery, chemotherapy, radiotherapy, hormone, and targeted therapy are the gold standards ... -
Circulating serum miR-200c and miR-34a-5p as diagnostic biomarkers for endometriosis
Misir, Sema; Hepokur, Ceylan; Oksasoglu, Bugra; Yildiz, Caglar; Yanik, Ali; Aliyazicioglu,Yüksel (2021)Objective: Endometriosis is defined by the presence of endometrial glands and stroma grow in areas outside the uterus. A simple blood test for endometriosis-specific biomarkers would offer a more timely accurate diagnosis ... -
Composition characterization and biological activity study of Achillea vermicularis extract and extract‐loaded nanoparticles
Murat Doğan; Ümit M Koçyiğit; Feyza Nur Çetin; Beyza Nur Yılmaz; Turgut Taşkın (JUMB, 2023/1/9)Antiproliferative activity of Achillea vermicularis extracts was calculated on glial (C6) and keratinocyte (HaCaT) cell lines using XTT assay. It was observed that all extracts of A. vermicularis at the determined concentration ...