Browsing Temel Eczacılık Bilimleri Bölümü Makale Koleksiyonu by Author "Hepokur,Ceylan"
Now showing items 1-8 of 8
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Anti-adhesive effect of naturally obtained dicalcium phosphate dihydrate nanoparticles in the rat uterine wound model
Objective: In this study, we aimed to compare the anti-adhesive effects of contractubex and dicalcium phosphate dihydrate (DCPD) particles in rats treated with the uterine horn adhesion model. Materials and methods: Newly ... -
Biomarker potentials of miRNA‑associated circRNAs in breast cancer (MCF‑7) cells: an in vitro and in silico study
Breast cancer is a heterogeneous disease, which is the most common malignancy in women. The incidence and mortality rates of breast cancer indicate that it is the leading cause of cancer-related with deaths. circRNAs ... -
Nanocomposite smart hydrogel based on sepiolite nanochannels/N-isopropyl acrylamide/itaconic acid/acrylamide for invertase immobilization
Novel nanocomposite smart hydrogel (NSH) and smart hydrogel (SH) are prepared to be used as a support for invertase. Spectrophotometric and thermal analysis methods were used for the characterization. Lower critical ... -
New Fluoro- and Trifluoromethyl-Substituted Trimethoxychalcones as Anticancer Agents: Synthesis, Bioevaluation, and Computational Studies
Polat,M. Fatih; Aktas Anil, Derya; Ozkemahli,Gizem; Turkmenoglu, Burcin; Hepokur,Ceylan; Burmaoglu,Serdar; Algul,Oztekin (2023)We designed and synthesized a novel series of trimethoxy chalcones with CF3 or F substituents at various positions of ring B, characterized using IR, NMR spectral data, and elemental analyses, based on the fact that ... -
Novel Bioactive Glass/Graphene Oxide-Coated Surgical Sutures for Soft Tissue Regeneration
The combination of a commercially available PGLA (poly[glycolide-co-L-lactide]), 90:10% suture material with bio active bioglass nanopowders (BGNs) and graphene oxide (GO)- doped BGNs offers new opportunities for the ... -
Propolis nanoparticles synthesis and characterization with cytotoxic and apoptotic effects on breast cancer cells
Ay,Ebru Nur; Caner,Armağan; Hepokur,Ceylan; Danişman Kalindemirtaş,Ferdane; Eroğlu, Güneş Özen; Kariper,Afşin (2023)The aim of this work was to investigate the antiproliferative and pro-apoptotic effects of propolis on human breast cancer cells using a simple and inexpensive nanoformulation. Various meth ods were used to characterize ... -
Synthesis of (4R)-2-(3-hydroxyphenyl)thiazolidine 4-carboxylic acid substituted phthalocyanines: Anticancer activity on different cancer cell lines and molecular docking studies
Bilgiçli, Ahmet T.; Genc Bilgicli,Hayriye; Hepokur,Ceylan; Tüzün,Burak; Günsel, Armagan; Zengin, Mustafa; Yarasir,M. Nilüfer (2021)In this study, firstly, (4R)-2-(3-hydroxyphenyl)thiazolidine-4-carboxylic acid (1) and (4R)-2-(3-(3,4-dicyanophenoxy)phenyl)thiazolidine-4-carboxylic acid (2) were prepared. Then, the novel type metallophthalocyanines ... -
Vitamin D increases the efcacy of cisplatin on bladder cancer cell lines
Özgen,Özge; Eroğlu,Güneş Özen; Küçükhüseyin,Özlem; Akdeniz,Nilgün; Hepokur,Ceylan; Kuruca,Serap; Yaylım,İlhan (2023)Background 1,25(OH)2D3(Calcitriol), which is a broad regulatory molecule, plays a role in changing the efcacy of chemo therapeutic drugs. Cisplatin is one of a current standard chemotherapy regimen for bladder cancer. ...