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Antimicrobial activity, inhibition of biofilm formation, and molecular docking study of novel Ag-NHC complexes
(ELSEVİER, 2021)
In this study, we reported the synthesis of a new series of Silver(I)-N-heterocyclic carbene complexes
which were obtained from the corresponding new N-heterocyclic carbene (NHC) precursors. All new
compounds were ...
Michael/Michael Addition Cascade of 2-Benzylidene-1- indanones with Chalcones: Synthesis and Biological Evaluations of Novel Polycyclic Compounds
(WİLLEY ONLİNE LİBRARY, 2021)
A series of novel racemic 2-aryloyl-1,3-diaryl-2,3,3a,8a-tetrahydrocyclopenta[
a]inden-8(1H)-one derivatives were synthesized
from KOtBu mediated Michael/Michael addition reaction of 2-
benzylidene-1-indanones with ...
Synthesis, characterization, antimicrobial and antibiofilm activity, and molecular docking analysis of NHC precursors and their Ag-NHC complexes†
(The Royal Society, 2021)
Microorganisms attach to surfaces and interfaces and form biofilms which create a sheltered area for host
cell response. Therefore, biofilms provide troubles in fields such as medicine, food, and pharmaceuticals.
Inhibition ...
Investigation of the Antimicrobial Agent Potential of 1,5-diketon Derivatives
(2021)
In this study 1,5-diketones were synthesized by adding of cyclohexzanone to five differtent calcone derivatives (1a-e) via di-1,4-Michael addition reaction. As a result the compounds with the best activity were 3a, 3b and ...
Investigation of Binding behaviour of a water-soluble gallium (III) phthalocyanine with double-stranded and G-quadruplex DNA via experimental and computational methods
(2021/9/15)
DNA is an important target for the development of chemotherapeutic drug design due to increased and uncontrolled cell proliferation of cancer cells. In the present study, the affinity of water-soluble gallium(III) ...
Interaction of water soluble cationic gallium (III) phthalocyanines with different G-quadruplex DNAs
(Elsevier, 1 November)
Small molecule-G-quadruplex DNA interaction has been gained considerable interest due to existence of G-quadruplex structures in telomeres and promotor regions of proto-oncogenes. In the present study, the interaction of ...
Synthesis of (4R)-2-(3-hydroxyphenyl)thiazolidine 4-carboxylic acid substituted phthalocyanines: Anticancer activity on different cancer cell lines and molecular docking studies
(2021)
In this study, firstly, (4R)-2-(3-hydroxyphenyl)thiazolidine-4-carboxylic acid (1)
and (4R)-2-(3-(3,4-dicyanophenoxy)phenyl)thiazolidine-4-carboxylic acid (2)
were prepared. Then, the novel type metallophthalocyanines ...
Tetra-substituted phthalocyanines bearing thiazolidine derivatives: synthesis, anticancer activity on different cancer cell lines, and molecular docking studies
(2021)
In the first step, (4R)-2-(2-hydroxyphenyl)thiazolidine-4-carboxylic acid (c) and 2-(2-(3,4-dicyano phenoxy)phenyl)thiazolidine-4-carboxylic acid (1) were prepared. Then, the peripherally tetra-substituted
metallophthalocyanines ...
Potential role of immune cell genetic variants associated with tumor microenvironment response in laryngeal squamous cell carcinoma (LSCC) in terms of clinicopathological features
(20 October)
Immunomodulatory signals regulate the self-tolerance, activation, priming and survival processes of T cells.
Programmed cell death protein 1 (PD1), Programmed death-ligand 1 (PD-L1) inhibitory signals and CD27, CD28 ...
Circulating serum miR-200c and miR-34a-5p as diagnostic biomarkers for endometriosis
(2021)
Objective: Endometriosis is defined by the presence of endometrial glands and stroma grow in areas
outside the uterus. A simple blood test for endometriosis-specific biomarkers would offer a more timely
accurate diagnosis ...