dc.contributor.author | Dastan, Taner | |
dc.contributor.author | Kocyigit, Umit M. | |
dc.contributor.author | Dastan, Sevgi Durna | |
dc.contributor.author | Kilickaya, Pakize Canturk | |
dc.contributor.author | Taslimi, Parham | |
dc.contributor.author | Cevik, Ozge | |
dc.contributor.author | Koparir, Metin | |
dc.contributor.author | Orek, Cahit | |
dc.contributor.author | Gulcin, Ilhami | |
dc.contributor.author | Cetin, Ahmet | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:40:02Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:40:02Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 1095-6670 | |
dc.identifier.issn | 1099-0461 | |
dc.identifier.uri | https://dx.doi.org/10.1002/jbt.21971 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/6621 | |
dc.description | WOS: 000414685200013 | en_US |
dc.description.abstract | The aim of this study was to evaluate biologically active novel molecules having potentials to be drugs by their antitumor properties and by activities of apoptotic caspase and topoisomerase. Following syntheses of novel eight bis(-aminoalkyl)phosphinic acid derivatives (4a-h) as a result of array of reactions, compounds were evaluated by cytotoxic effects in vitro on human breast cancer (MCF-7) and normal endothelial (HUVEC) cell lines. All phosphinic acid derivatives were effective for cytotoxicity on both MCF-7 and HUVEC lines, while 4c, 4e, and 4f compounds were found significantly more effective. For the evaluation of antitumor properties of compounds in a highly sensitive method, their effects on inhibiting topoisomerases I and II were investigated. Also, some of the bis(-aminoalkyl)phosphinic acid derivatives (4a, 4e-h) showed nice inhibitory action against acetylcholinesterase and human carbonic anhydrase isoforms I and II. | en_US |
dc.description.sponsorship | Cumhuriyet University Research Fund (CUBAP) [V-060] | en_US |
dc.description.sponsorship | We acknowledge with great pleasure the partly support provided by Cumhuriyet University Research Fund (CUBAP), project no: V-060. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | WILEY | en_US |
dc.relation.isversionof | 10.1002/jbt.21971 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | acetylcholinesterase | en_US |
dc.subject | cytotoxicity | en_US |
dc.subject | carbonic anhydrase | en_US |
dc.subject | phosphinic acid | en_US |
dc.subject | topoisomerase | en_US |
dc.title | Investigation of acetylcholinesterase and mammalian DNA topoisomerases, carbonic anhydrase inhibition profiles, and cytotoxic activity of novel bis(-aminoalkyl)phosphinic acid derivatives against human breast cancer | en_US |
dc.type | article | en_US |
dc.relation.journal | JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY | en_US |
dc.contributor.department | [Dastan, Taner -- Cetin, Ahmet] Bingol Univ, Fac Arts & Sci, Div Organ Chem, Dept Chem, TR-12000 Bingol, Turkey -- [Kocyigit, Umit M.] Cumhuriyet Univ, Vocat Sch Hlth Serv, TR-58140 Sivas, Turkey -- [Dastan, Sevgi Durna] Cumhuriyet Univ, Div Biometry & Genet, Dept Anim Nutr & Zootech, Fac Vet Med, TR-58140 Sivas, Turkey -- [Kilickaya, Pakize Canturk] Cumhuriyet Univ, Sch Pharm, Dept Pharmaceut Biotechnol, TR-58140 Sivas, Turkey -- [Taslimi, Parham -- Gulcin, Ilhami] Ataturk Univ, Dept Chem, Fac Sci, TR-25240 Erzurum, Turkey -- [Cevik, Ozge] Cumhuriyet Univ, Sch Pharm, Dept Biochem, TR-58140 Sivas, Turkey -- [Koparir, Metin -- Orek, Cahit] Firat Univ, Fac Arts & Sci, Div Organ Chem, Dept Chem, TR-23169 Elazig, Turkey | en_US |
dc.contributor.authorID | GULCIN, Ilhami -- 0000-0001-5993-1668; Cevik, Ozge -- 0000-0002-9325-3757; orek, cahit -- 0000-0002-3854-1537 | en_US |
dc.identifier.volume | 31 | en_US |
dc.identifier.issue | 11 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |