dc.contributor.author | Bakir, Mehmet | |
dc.contributor.author | Engin, Aynur | |
dc.contributor.author | Kuskucu, Mert Ahmet | |
dc.contributor.author | Bakir, Sevtap | |
dc.contributor.author | Gundag, Omur | |
dc.contributor.author | Midilli, Kenan | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:45:14Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:45:14Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 0146-6615 | |
dc.identifier.issn | 1096-9071 | |
dc.identifier.uri | https://dx.doi.org/10.1002/jmv.24446 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/7287 | |
dc.description | WOS: 000374061600006 | en_US |
dc.description | PubMed ID: 26680021 | en_US |
dc.description.abstract | Crimean-Congo hemorrhagic fever (CCHF) is a viral infection. Circulating plasma cell-free DNA (pcf-DNA) is a novel marker indicating cellular damage. So far, the role of pcf-DNA did not investigate in CCHF patients. In the current study, pcf-DNA levels were investigated in CCHF patients with different clinical severity grades to explore the relationship between circulating pcf-DNA level, virus load, and disease severity. Seventy-two patients were categorized as mild, intermediate, and severe based on severity grading scores. The pcf-DNA level was obtained from all participants on admission and from the survivors on the day of the discharge. The controls consisted of 31 healthy. Although the pcf-DNA level at admission was higher in patients than in the controls, the difference was not statistically significant (P=0.291). However, at admission and in the convalescent period, the difference between pcf-DNA levels in mild, intermediate, and severe patient groups was significant. The pcf-DNA level in severe patients was higher than in the others. Furthermore, compared to survivors, non-survivors had higher pcf-DNA levels at admission (P=0.001). A direct relationship was found between the pcf-DNA level and the viral load on the day of discharge in surviving patients. ROC curve analysis identified a pcf-DNA level of 0.42 as the optimal cut-off for prediction of mortality. The positive predictive value, negative predictive value, specificity, and sensitivity for predicting mortality was 100%, 72%, 100%, and 79%, respectively. In summary, our findings revealed that pcf-DNA levels may be used as a biomarker in predicting CHHF prognosis. J. Med. Virol. 88:1152-1158, 2016. (c) 2015 Wiley Periodicals, Inc. | en_US |
dc.description.sponsorship | Research council of Cumhuriyet University [T-552] | en_US |
dc.description.sponsorship | Grant sponsor: Research council of Cumhuriyet University; Grant number: T-552 | en_US |
dc.language.iso | eng | en_US |
dc.publisher | WILEY | en_US |
dc.relation.isversionof | 10.1002/jmv.24446 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Crimean-Congo hemorrhagic fever | en_US |
dc.subject | prognosis | en_US |
dc.subject | mortality | en_US |
dc.subject | cell-free DNA | en_US |
dc.title | Relationship of plasma cell-free DNA level with mortality and prognosis in patients with Crimean-Congo hemorrhagic fever | en_US |
dc.type | article | en_US |
dc.relation.journal | JOURNAL OF MEDICAL VIROLOGY | en_US |
dc.contributor.department | [Bakir, Mehmet -- Engin, Aynur -- Gundag, Omur] Cumhuriyet Univ, Fac Med, Dept Infect Dis & Clin Microbiol, TR-58140 Sivas, Turkey -- [Kuskucu, Mert Ahmet -- Midilli, Kenan] Istanbul Univ, Cerrahpasa Med Fac, Dept Microbiol, Istanbul, Turkey -- [Bakir, Sevtap] Cumhuriyet Univ, Fac Med, Dept Biochem, TR-58140 Sivas, Turkey | en_US |
dc.identifier.volume | 88 | en_US |
dc.identifier.issue | 7 | en_US |
dc.identifier.endpage | 1158 | en_US |
dc.identifier.startpage | 1152 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |