Show simple item record

dc.contributor.authorBakir, Mehmet
dc.contributor.authorEngin, Aynur
dc.contributor.authorKuskucu, Mert Ahmet
dc.contributor.authorBakir, Sevtap
dc.contributor.authorGundag, Omur
dc.contributor.authorMidilli, Kenan
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:45:14Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:45:14Z
dc.date.issued2016
dc.identifier.issn0146-6615
dc.identifier.issn1096-9071
dc.identifier.urihttps://dx.doi.org/10.1002/jmv.24446
dc.identifier.urihttps://hdl.handle.net/20.500.12418/7287
dc.descriptionWOS: 000374061600006en_US
dc.descriptionPubMed ID: 26680021en_US
dc.description.abstractCrimean-Congo hemorrhagic fever (CCHF) is a viral infection. Circulating plasma cell-free DNA (pcf-DNA) is a novel marker indicating cellular damage. So far, the role of pcf-DNA did not investigate in CCHF patients. In the current study, pcf-DNA levels were investigated in CCHF patients with different clinical severity grades to explore the relationship between circulating pcf-DNA level, virus load, and disease severity. Seventy-two patients were categorized as mild, intermediate, and severe based on severity grading scores. The pcf-DNA level was obtained from all participants on admission and from the survivors on the day of the discharge. The controls consisted of 31 healthy. Although the pcf-DNA level at admission was higher in patients than in the controls, the difference was not statistically significant (P=0.291). However, at admission and in the convalescent period, the difference between pcf-DNA levels in mild, intermediate, and severe patient groups was significant. The pcf-DNA level in severe patients was higher than in the others. Furthermore, compared to survivors, non-survivors had higher pcf-DNA levels at admission (P=0.001). A direct relationship was found between the pcf-DNA level and the viral load on the day of discharge in surviving patients. ROC curve analysis identified a pcf-DNA level of 0.42 as the optimal cut-off for prediction of mortality. The positive predictive value, negative predictive value, specificity, and sensitivity for predicting mortality was 100%, 72%, 100%, and 79%, respectively. In summary, our findings revealed that pcf-DNA levels may be used as a biomarker in predicting CHHF prognosis. J. Med. Virol. 88:1152-1158, 2016. (c) 2015 Wiley Periodicals, Inc.en_US
dc.description.sponsorshipResearch council of Cumhuriyet University [T-552]en_US
dc.description.sponsorshipGrant sponsor: Research council of Cumhuriyet University; Grant number: T-552en_US
dc.language.isoengen_US
dc.publisherWILEYen_US
dc.relation.isversionof10.1002/jmv.24446en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCrimean-Congo hemorrhagic feveren_US
dc.subjectprognosisen_US
dc.subjectmortalityen_US
dc.subjectcell-free DNAen_US
dc.titleRelationship of plasma cell-free DNA level with mortality and prognosis in patients with Crimean-Congo hemorrhagic feveren_US
dc.typearticleen_US
dc.relation.journalJOURNAL OF MEDICAL VIROLOGYen_US
dc.contributor.department[Bakir, Mehmet -- Engin, Aynur -- Gundag, Omur] Cumhuriyet Univ, Fac Med, Dept Infect Dis & Clin Microbiol, TR-58140 Sivas, Turkey -- [Kuskucu, Mert Ahmet -- Midilli, Kenan] Istanbul Univ, Cerrahpasa Med Fac, Dept Microbiol, Istanbul, Turkey -- [Bakir, Sevtap] Cumhuriyet Univ, Fac Med, Dept Biochem, TR-58140 Sivas, Turkeyen_US
dc.identifier.volume88en_US
dc.identifier.issue7en_US
dc.identifier.endpage1158en_US
dc.identifier.startpage1152en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record