dc.contributor.author | Deveci, K. | |
dc.contributor.author | Gokakin, A. K. | |
dc.contributor.author | Senel, S. | |
dc.contributor.author | Deveci, H. | |
dc.contributor.author | Uslu, A. U. | |
dc.contributor.author | Sancakdar, E. | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:03:09Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:03:09Z | |
dc.date.issued | 2013 | |
dc.identifier.issn | 1128-3602 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/8886 | |
dc.description | WOS: 000319224700017 | en_US |
dc.description | PubMed ID: 23377817 | en_US |
dc.description.abstract | BACKGROUND: The major renal involvement in Familial Mediterranean Fever (FMF) is the occurrence of amyloidosis that primarily affects the kidneys manifested by proteinuria and ending in death from renal failure. AIM: This study aims to investigate whether serum cystatin (cys-C) levels could be used as an early marker of renal involvement in FMF patients. PATIENTS AND METHODS: Forty-six patients with FMF during the attack period (AP), and 41 patients with FMF during attack-free periods (AFP), and 11 patients with FMF associated amyloidosis, and 38 healthy controls were enrolled in the study. We determined cys-C levels in the serum of FMF patients and healthy controls. RESULTS: Serum cys-C levels were significantly increased in patients with FMF and secondary amyloidosis, and serum cys-C is a more accurate and efficient marker for detecting renal involvement than estimated glomerular filtration rate (e-GFR) in patients with FMF. CONCLUSIONS: We propose a cutoff level of the serum cys-C of 876.5 pg/mL for screening renal involvement in patients with FMF, and amyloidosis should be strongly suspected when the serum cys-C reaches 1565.5 pg/mL. | en_US |
dc.description.sponsorship | Research Foundation Council of Cumhuriyet University [T-478] | en_US |
dc.description.sponsorship | The Research Foundation Council of Cumhuriyet University partly supported this study (Project No. T-478). The Authors declare no other financial interests relevant to the present study. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | VERDUCI PUBLISHER | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Familial mediterranean fever | en_US |
dc.subject | Cystatin C | en_US |
dc.subject | Amyloidosis | en_US |
dc.title | Cystatin C in serum as an early marker of renal involvement in Familial Mediterranean Fever patients | en_US |
dc.type | article | en_US |
dc.relation.journal | EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES | en_US |
dc.contributor.department | [Deveci, K. -- Sancakdar, E.] Cumhuriyet Univ, Sch Med, Dept Clin Biochem, Sivas, Turkey -- [Gokakin, A. K.] Cumhuriyet Univ, Sch Med, Dept Gen Surg, Sivas, Turkey -- [Senel, S.] Cumhuriyet Univ, Sch Med, Dept Internal Med, Sivas, Turkey -- [Deveci, H.] Erciyes Univ, Sch Med, Dept Rheumatol, Kayseri, Turkey -- [Uslu, A. U.] Numune State Hosp, Dept Phys Med & Rehabil, Sivas, Turkey | en_US |
dc.identifier.volume | 17 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.endpage | 260 | en_US |
dc.identifier.startpage | 253 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |