dc.contributor.author | Manduz, Sinasi | |
dc.contributor.author | Katrancioglu, Nurkay | |
dc.contributor.author | Karahan, Oguz | |
dc.contributor.author | Yilmaz, Mehmet Birhan | |
dc.contributor.author | Ozdemir, Ozturk | |
dc.contributor.author | Berkan, Ocal | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:05:44Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:05:44Z | |
dc.date.issued | 2011 | |
dc.identifier.issn | 1301-5680 | |
dc.identifier.uri | https://dx.doi.org/10.5606/tgkdc.dergisi.2011.008 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/9565 | |
dc.description | WOS: 000290003200008 | en_US |
dc.description.abstract | Background: The aim of the study was to reveal the effect of the C3435T MDR-1 gene polymorphism in AAA, which has been postulated to play a role in the inflammatory process and protection against oxidative stress. Methods: In this study, we scanned the MDR gene polymorphisms in peripheral blood samples of the 58 patients (41 males, 17 females; mean age 62.9 +/- 6.6 years) whom were operated on after the diagnosis of AAA, and of the 58 healthy individuals (38 males, 20 females; mean age 58.8 +/- 11.6 years) have normally measured aorta diameters on abdominal computed tomography scan. Results: We found that MDR-1 C3435T gene CT variant (x(2)=5.80; p=0.016) and MDR-1 C3435T gene TT variant (x(2)=11.47; p=0.001) polymorphisms was statistically significant in AAA cases (p<0.05). The demographic findings were similar in each group. Conclusion: These obtained preliminary results suggest that the T allele polymorphism of the MDR-1 gene is associated with AAA. We belive that such molecular studies will blaze a trail for future studies on the understanding of AAA etiology. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | EKIN TIBBI YAYINCILIK LTD STI-EKIN MEDICAL PUBL | en_US |
dc.relation.isversionof | 10.5606/tgkdc.dergisi.2011.008 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Abdominal aortic aneurysm | en_US |
dc.subject | inflammation | en_US |
dc.subject | MDR-1 | en_US |
dc.subject | gene polymorphism | en_US |
dc.subject | reverse hybridization | en_US |
dc.title | Associations between common 3435 C > T variants of the multi-drug resistance [MDR-1 (ABCB1)] gene and abdominal aortic aneurysm: a pilot study | en_US |
dc.type | article | en_US |
dc.relation.journal | TURK GOGUS KALP DAMAR CERRAHISI DERGISI-TURKISH JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY | en_US |
dc.contributor.department | [Manduz, Sinasi -- Katrancioglu, Nurkay -- Karahan, Oguz -- Berkan, Ocal] Cumhuriyet Univ, Tip Fak, Kalp & Damar Cerrahisi Anabilim Dali, TR-58140 Sivas, Turkey -- [Yilmaz, Mehmet Birhan] Cumhuriyet Univ, Tip Fak, Dept Cardiol, TR-58140 Sivas, Turkey -- [Ozdemir, Ozturk] Cumhuriyet Univ, Tip Fak, Dept Med Genet, TR-58140 Sivas, Turkey | en_US |
dc.contributor.authorID | YILMAZ, MEHMET BIRHAN -- 0000-0002-8169-8628; Karahan, Oguz -- 0000-0003-0044-9476 | en_US |
dc.identifier.volume | 19 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.endpage | 181 | en_US |
dc.identifier.startpage | 177 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |