eNOS G894T Polymorphism and Abdominal Aortic Aneurysms
Date
2010Author
Atli, Fahri HayriManduz, Sinasi
Katrancioglu, Nurkay
Ozum, Unal
Disli, Olcay Murat
Atahan, Erhan
Ozdemir, Ozturk
Dogan, Kasim
Berkan, Ocal
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Background: The genetic risk factors that contribute to the risk of developing abdominal aortic aneurysm ( AAA) are poorly understood. We assessed the association of endothelial nitric oxide synthase ( eNOS) gene polymorphism with AAA. Methods: eNOS gene polymorphism of 61 patients with AAA and 62 control participants were analyzed by polymerase chain reaction (PCR)-restriction technique. Results: eNOS G894 homozygote T/T genotype polymorphism and 894T allele frequency in patients with AAA were significantly higher than those of the control participants (P=.01, P=.03). Among patients with AAA, the eNOS G894 T/T polymorphism and 894T allele frequency were associated with larger AAAs. Conclusion: The current study, in a small group of participants, showed a relationship between eNOS G894T polymorphism and AAA.
Source
ANGIOLOGYVolume
61Issue
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