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eNOS G894T Polymorphism and Abdominal Aortic Aneurysms

Date

2010

Author

Atli, Fahri Hayri
Manduz, Sinasi
Katrancioglu, Nurkay
Ozum, Unal
Disli, Olcay Murat
Atahan, Erhan
Ozdemir, Ozturk
Dogan, Kasim
Berkan, Ocal

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Abstract

Background: The genetic risk factors that contribute to the risk of developing abdominal aortic aneurysm ( AAA) are poorly understood. We assessed the association of endothelial nitric oxide synthase ( eNOS) gene polymorphism with AAA. Methods: eNOS gene polymorphism of 61 patients with AAA and 62 control participants were analyzed by polymerase chain reaction (PCR)-restriction technique. Results: eNOS G894 homozygote T/T genotype polymorphism and 894T allele frequency in patients with AAA were significantly higher than those of the control participants (P=.01, P=.03). Among patients with AAA, the eNOS G894 T/T polymorphism and 894T allele frequency were associated with larger AAAs. Conclusion: The current study, in a small group of participants, showed a relationship between eNOS G894T polymorphism and AAA.

Source

ANGIOLOGY

Volume

61

Issue

2

URI

https://dx.doi.org/10.1177/0003319709339589
https://hdl.handle.net/20.500.12418/9928

Collections

  • Makale Koleksiyonu [5200]
  • Makale Koleksiyonu [5745]
  • Öksüz Yayınlar Koleksiyonu - WoS [6162]



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