dc.contributor.author | Dogan, Omer Tamer | |
dc.contributor.author | Katrancioglu, Nurkay | |
dc.contributor.author | Karahan, Oguz | |
dc.contributor.author | Sanli, Gulizar Canan | |
dc.contributor.author | Zorlu, Ali | |
dc.contributor.author | Manduz, Sinasi | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:13:49Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:13:49Z | |
dc.date.issued | 2010 | |
dc.identifier.issn | 1807-5932 | |
dc.identifier.uri | https://dx.doi.org/10.1590/S1807-59322010001100010 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/9949 | |
dc.description | WOS: 000288492000010 | en_US |
dc.description | PubMed ID: 21243282 | en_US |
dc.description.abstract | BACKGROUND AND AIM: The multi-drug resistant-1 (MDR-1) gene is located on human chromosome 7 and encodes a glycosylated membrane protein that is a member of the ATP-binding cassette transporters superfamily. The aim of the study was to reveal the role of the C3435T MDR-1 gene polymorphism in chronic obstructive pulmonary disease. METHOD: DNA samples from 41 patients with chronic obstructive pulmonary disease and 50 healthy control participants were used to compare MDR-1 gene profiles. Genotyping assays were performed using the StripAssay technique that is based on reverse-hybridization. RESULTS: The T allele polymorphism in the MDR-1 gene located at position 3435 in exon 26 was shown to correlate with chronic obstructive pulmonary disease. CONCLUSION: These preliminary results suggest that the T allele polymorphism of the MDR-1 gene is associated with chronic obstructive pulmonary disease. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | HOSPITAL CLINICAS, UNIV SAO PAULO | en_US |
dc.relation.isversionof | 10.1590/S1807-59322010001100010 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | COPD | en_US |
dc.subject | MDR-1 gene | en_US |
dc.subject | T allele frequency | en_US |
dc.subject | Transporter glycoprotein | en_US |
dc.subject | Reverse-hybridization | en_US |
dc.title | Frequency of the mdr-1 C > T gene polymorphism in patients with COPD | en_US |
dc.type | article | en_US |
dc.relation.journal | CLINICS | en_US |
dc.contributor.department | [Dogan, Omer Tamer -- Sanli, Gulizar Canan] Cumhuriyet Univ, Fac Med, Dept Chest Dis, Sivas, Turkey -- [Katrancioglu, Nurkay -- Karahan, Oguz -- Manduz, Sinasi] Cumhuriyet Univ, Dept Cardiovasc Surg, Fac Med, Sivas, Turkey -- [Zorlu, Ali] Cumhuriyet Univ, Dept Cardiol, Fac Med, Sivas, Turkey | en_US |
dc.contributor.authorID | Karahan, Oguz -- 0000-0003-0044-9476 | en_US |
dc.identifier.volume | 65 | en_US |
dc.identifier.issue | 11 | en_US |
dc.identifier.endpage | 1117 | en_US |
dc.identifier.startpage | 1115 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |