Browsing by Author "Sarioglu, Y"
Now showing items 1-20 of 33
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Aging impairs nitric oxide-mediated relaxant responses of rabbit corporal smooth muscle
Utkan, T; Yildirim, S; Sarioglu, Y; Yildiz, F; Yildirim, K (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2002)Aging has been reported to cause impotence, the mechanism of which is unknown. Therefore, we investigated the effect of aging on electrical stimulation-induced neurogenic, carbachol-induced, endothelium-dependent, and ... -
Changes in the nitric oxide system of rat myometrium during midgestation and delivery at term
Kaya, T; Cetin, A; Sarioglu, Y (ACADEMIC PRESS LTD, 1998)The aims of this study were to investigate whether a nitric oxide (NO) system is present in the pregnant rat myometrium and whether it differentially inhibits myometrial contractility during midgestation and delivery at ... -
Corporal reactivity to adenosine and prostaglandin E-1 in alloxan-induced diabetic rabbit corpus cavernosum, and the effect of insulin therapy
Ayan, S; Yildirim, S; Ucar, C; Sarioglu, Y; Gultekin, Y; Butuner, C (BLACKWELL SCIENCE LTD, 1999)Objective To investigate the changes in corporal reactivity to adenosine and prostaglandin E-1 (PGE(1)) in corpus cavernosal strips from alloxan-induced diabetic rabbits and to determine the effects of insulin therapy. ... -
Does diabetes mellitus affect the progress of tolerance to isosorbide dinitrate (ISDN) in corporal tissue?
Yildirim, S; Ayan, S; Sarioglu, Y; Gultekin, Y; Uma, S (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2000)For erection to take place, the penile arteries and sinusoids have to dilate, thereby increasing the blood flow into the penis. There is increasing evidence that release of L-arginine derived nitric oxide (NO) from ... -
Effect of additional testosterone on purinergic responses in isolated rabbit corpus cavernosum strips
Kaya, T; Sarioglu, Y; Goksu, OC; Yildirim, S; Yildirim, K (ACADEMIC PRESS LTD, 1998)Recently, it has been demonstrated that the endothelium of corpus cavernosum (CC) plays an important role on smooth muscle relaxation, which is crucial to initiate and maintain erection. We investigated the effect of ... -
Effect of chronic renal failure on the purinergic responses of corpus cavernosal smooth muscle in rabbits
Kilicarslan, H; Yildirim, S; Bagcivan, I; Ayan, S; Sarac, B; Sarioglu, Y (WILEY, 2002)Objective To examine purinergic relaxation responses in chronic renal failure (CRF) in an experimental rabbit model, and thus evaluate the possible involvement of the purinergic system in erectile dysfunction with CRF. ... -
Effect of deferoxamine and sympathectomy on vasospasm following subarachnoid hemorrhage
We examined the effects of subarachnoid hemorrhage (SAH) and treatment with deferoxamine (DFO) or sympathectomy on vascular smooth muscle function, as well as the underlying mechanisms involved, by recording the responses ... -
Effect of endothelin-1 on spontaneous contractions and effects of nimodipine and isradipine on endothelin-1-induced contractions in myometrial strips isolated from normal pregnant and preeclamptic women
Kaya, T; Cetin, A; Cetin, M; Sarioglu, Y (MUNKSGAARD INT PUBL LTD, 1998)Background. To examine the effect of endothelin-l (ET-1) on spontaneous contractile activity and the effects of nimodipine and isradipine on ET-l-induced contractile responses in myometrial strips isolated from normal ... -
Effects of castration on adrenergic, cholinergic and nonadrenergic, noncholinergic responses of isolated corpus cavernosum from rabbit
Yildirim, MK; Yildirim, S; Utkan, T; Sarioglu, Y; Yalman, Y (BLACKWELL SCIENCE LTD, 1997)Objective To investigate the effects of castration and testosterone on the constricting effect of phenylephrine and endothelium-dependent and -independent relaxing effects of different agonists in the corpus cavernosum of ... -
Effects of deferoxamine and sympathectomy on endothelin-1-induced contraction and acetylcholine-induced relaxation following subarachnoid hemorrhage in carotid artery
Sarioglu, Y; Utkan, T; Akgun, M; Duzcan, E; Utkan, NZ (ELSEVIER SCIENCE INC, 1997)The role of endothelium-related factors in the pathogenesis of cerebral vasospasm after subarachnoid hemorrhage (SAH) has gained interest since the discovery of EDRF and of endothelin (ET-1). The effect of SAH and both ... -
Effects of endothelin-1 and calcium channel blockers on contractions in human myometrium - A study on myometrial strips from normal and diabetic pregnant women
Kaya, T; Cetin, A; Cetin, M; Sarioglu, Y (SCI PRINTERS & PUBL INC, 1999)OBJECTIVE: We studied the effect of endothelin (ET)-1 on spontaneous contractions and the effects of nimodipine and isradipine on ET-l-induced contractions in myometrial tissue from normal and diabetic pregnant women. STUDY ... -
Effects of exogenous testosterone on isolated rabbit corpus cavernosum penis
Yildirim, S; Utkan, T; Yildirim, K; Sarioglu, Y (ACTA PHARMACOLOGICA SINICA, 2000)AIM: To study the effects of exogenous excess of testosterone on the constricting effect of phenylephrine and endothelium-dependent and -independent relaxing effects of different:agonists in the corpus cavernosum penis ... -
Effects of experimental obstructive jaundice on contractile responses of dog isolated blood vessels: Role of endothelium and duration of bile duct ligation
Utkan, ZN; Utkan, T; Sarioglu, Y; Gonullu, NN (BLACKWELL SCIENCE ASIA, 2000)1. We examined the effects of experimental obstructive jaundice caused by bile duct ligation (BDL) on vascular smooth muscle function, as well as the underlying mechanisms involved, by recording responses to noradrenaline ... -
The effects of long-term oral administration of L-arginine on the erectile response of rabbits with alloxan-induced diabetes
Yildirim, S; Ayan, S; Sarioglu, Y; Gultekin, Y; Butuner, C (BLACKWELL SCIENCE LTD, 1999)Objective To investigate the effects of the long-term oral administration of L-arginine on the impaired neurogenic and endothelium-dependent relaxation responses of corpus cavernosum smooth muscle from alloxan-induced ... -
The effects of long-term oral L-arginine on the erectile response of rabbits with alloxan-induced diabetes - Reply
Yildirim, S; Ayan, S; Sarioglu, Y; Gultekin, Y; Butuner, C (BLACKWELL SCIENCE LTD, 1999)… -
Effects of nimodipine and isradipine on endothelin-1-induced contraction of pregnant rat myometrium
Kaya, T; Cetin, A; Cetin, M; Sarioglu, Y (ELSEVIER SCIENCE BV, 1998)The purpose of this study was to investigate the effect of nimodipine and isradipine on endothelin-1-induced contractions of isolated pregnant rat myometrium. Endothelin-1 at 10(-10)-10(-8) M dose-dependently increased the ... -
Effects of sympathectomy on endothelin-1 and histamine responses of rabbit carotid artery
Utkan, T; Kaya, T; Sarioglu, Y (ELSEVIER SCIENCE INC, 1997)1. The effects of chronic sympathectomy on contractile responses of rabbit common carotid artery was studied in vitro. 2. Endothelin-1 (ET-I), histamine, KCl and papaverine concentration-response curves of sympathectomized ... -
Effects of the specific phosphodiesterase inhibitors on alloxan-induced diabetic rabbit cavernous tissue in vitro
Utkan, T; Yildirim, MK; Yildirim, S; Sarioglu, Y (NATURE PUBLISHING GROUP, 2001)An experimental study was done to examine a potential role of phosphodiesterase (PDE) inhibitors in the treatment of diabetic erectile dysfunction, Relaxant effect of specific PDE inhibitors were measured in strips of ... -
Enhancement of EFS-induced contractions, by agmatine, in guinea pig gallbladder smooth muscle strips
Yildirim, S; Aydin, C; Koyuncu, A; Bagcivan, I; Sarac, B; Sarioglu, Y (SPRINGER TOKYO, 2005)Background. Electrical field stimulation of gallbladder muscle strips produces frequency-dependent contractions by activating cholinergic nerves. The cholinergic motor function of the gallbladder and enteric system is also ... -
Evidence of relaxant effect of omeprazole in rabbit corpus cavernosum in vitro
Sarioglu, Y; Yildirim, S; Utkan, T; Yildirim, MK; Uma, S (PERGAMON-ELSEVIER SCIENCE LTD, 2000)The present experiments were designed to investigate the effects of omeprazole, a H+-K+ ATPase inhibitor, on corporal smooth muscle tone in vitro. All spontaneous contractile activity in the corpus cavernosum was blocked ...