Browsing by Author "Tutar, Yusuf"
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Acyl Thiourea Derivatives Containing Pyrazole Ring Selective Targeting of Human Aurora Kinases in Breast and Bone Cancer
Ozgur, Aykut; Yenidunya, Eren; Koca, Irfan; Tutar, Yusuf (BENTHAM SCIENCE PUBL LTD, 2015)Several oncogenic pathways may lead to cancer. Pharmaceutical research develops efficacious compounds to inhibit these pathways. Current inhibitor drugs may block several pathways simultaneously but cause adverse and side ... -
Anticancer activities of manganese-based photoactivatable CO-releasing complexes (PhotoCORMs) with benzimidazole derivative ligands
Ustun, Elvan; Ozgur, Aykut; Coskun, Kubra A.; Dusunceli, Serpil Demir; Ozdemir, Ismail; Tutar, Yusuf (SPRINGER, 2017)Carbon monoxide is an important signaling molecule which is produced by heme oxygenase-1. CO shows antiproliferative activity against cancer cells; hence, activation of HO-1 is a significant inhibition strategy against ... -
Chemical linkage at allosteric activation of E-Coli cAMP receptor protein
Tutar, Yusuf (SPRINGER, 2008)Cyclic AMP Receptor protein (CRP) regulates transcription initiation in E. coli. The ligand and DNA binding data yields the following results: (1) There are two different types of cAMP binding sites; weak and strong. (2) ... -
CO-releasing properties and anticancer activities of manganese complexes with imidazole/benzimidazole ligands
Ustun, Elvan; Ozgur, Aykut; Coskun, Kubra A.; Demir, Serpil; Ozdemir, Ismail; Tutar, Yusuf (TAYLOR & FRANCIS LTD, 2016)Carbon monoxide (CO) is an important signaling molecule which plays significant roles in the pathogenesis of cancer. CO is produced by enzymatic degradation of heme in mammals. Heme oxygenase 1 (HO-1) catalyzes the breakdown ... -
CRP subunit association and hinge conformation changes in response to cAMP binding: Analysis of C-helix cysteine-substituted CRP
Tomlinson, Steven R.; Tutar, Yusuf; Harman, James G. (AMER CHEMICAL SOC, 2006)We investigated the characteristics of 13 CRP variants having cysteine substituted at positions 113, 115, 116, 117, 118, 120, 122, 124, 126, 127, 129, 130, or 131, positions that span the length of the CRP C alpha-helix. ... -
Design and synthesis of pyrimidinyl acyl thioureas as novel Hsp90 inhibitors in invasive ductal breast cancer and its bone metastasis
Koca, Irfan; Ozgur, Aykut; Er, Muhammet; Gumus, Mehmet; Coskun, Kubra Acikalin; Tutar, Yusuf (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2016)Invasive ductal carcinoma is the most common breast malignancies tumors and has tendency to bone metastases. Many oncogenic client proteins involved in formation of metastatic pathways. Stabilization, regulation, and ... -
Design, Synthesis, and Evaluation of Heat Shock Protein 90 Inhibitors in Human Breast Cancer and Its Metastasis
Gumus, Mehmet; Ozgur, Aykut; Tutar, Lutfi; Disli, Ali; Koca, Irfan; Tutar, Yusuf (BENTHAM SCIENCE PUBL LTD, 2016)Background: Despite development of novel cancer drugs, invasive ductal breast carcinoma and its metastasis are still highly morbid. Therefore, new therapeutic approaches are being developed and Hsp90 is an important target ... -
Determination of Optimum Operation Parameters for Low-Intensity Pulsed Ultrasound and Low-Level Laser Based Treatment to Induce Proliferation of Osteoblast and Fibroblast Cells
Coskun, Mehmet Emre; Coskun, Kubra Acikalin; Tutar, Yusuf (MARY ANN LIEBERT, INC, 2018)Objective: The aim of this study was to determine the optimum operating parameters (pulse duration, energy levels, and application time) to promote induction of osteoblast and fibroblast cell proliferation and to maintain ... -
Dynamic Fluctuations Provide the Basis of a Conformational Switch Mechanism in Apo Cyclic AMP Receptor Protein
Fas, Burcu Aykac; Tutar, Yusuf; Haliloglu, Turkan (PUBLIC LIBRARY SCIENCE, 2013)Escherichia coli cyclic AMP Receptor Protein (CRP) undergoes conformational changes with cAMP binding and allosterically promotes CRP to bind specifically to the DNA. In that, the structural and dynamic properties of apo ... -
Effect of salt bridge on transcription activation of CRP-dependent lactose operon in Escherichia coli
Tutar, Yusuf; Harman, James G. (ELSEVIER SCIENCE INC, 2006)Expression of catabolite-sensitive operons in Escherichia coli is cAMP-dependent and mediated through the CRP:cAMP complex binding to specific sequences in DNA. Five specific ionic or polar interactions occur in cAMP binding ... -
Heat Shock Protein 40-Gok1 Isolation from Toxoplasma gondii RH Strain
Coskun, Kubra A.; Ozgur, Aykut; Otag, Begum; Mungan, Mesut; Tutar, Yusuf (BENTHAM SCIENCE PUBL LTD, 2013)Toxoplasma gondii is ubiquitous obligate intracellular parasite and is one of the most important pathogen for humans and animals. In humans, T. gondii has two life forms: tachyzoites and bradyzoites. Tachyzoites form of ... -
Heat shock protein 70 purification and characterization from Cyprinion macrastomus macrastomus and Garra rufa obtusa
Tutar, Yusuf; Okan, Sule (PERGAMON-ELSEVIER SCIENCE LTD, 2012)Organisms resist stress factors by common mechanisms at cellular and physiological levels. Heat shock proteins (Hsps) play an essential role as a protective mechanism against stressors, and Hsp70 has a central role in the ... -
Heat Shock Protein 90 Inhibition in Cancer Drug Discovery: From Chemistry to Futural Clinical Applications
Ozgur, Aykut; Tutar, Yusuf (BENTHAM SCIENCE PUBL LTD, 2016)Heat shock protein 90 (Hsp90) is an important member of the chaperone protein family and it is involved in stabilization, regulation, and maintenance of oncogenic client proteins with co-chaperones. Co-chaperones regulate ... -
Heat Shock Protein 90 Inhibitors in Oncology
Ozgur, Aykut; Tutar, Yusuf (BENTHAM SCIENCE PUBL LTD, 2014)Heat shock protein 90 (Hsp90) is highly conserved chaperone protein which plays vital roles in stabilization, regulation and folding of client proteins in cancer cells. Client proteins are key macromolecules for carcinogenesis ... -
Heat shock proteins, substrate specificity and modulation of function
Tutar, Yusuf (BENTHAM SCIENCE PUBL LTD, 2006)Hsp70 is a universally conserved essential protein chaperone. In addition to its roles in many cellular process, Hsp70 protects cells from stress by binding partially unfolded proteins. Therefore, Hsp70 prevents protein ... -
Heat Shock Proteins; An Overview
Tutar, Lutfi; Tutar, Yusuf (BENTHAM SCIENCE PUBL LTD, 2010)Heat shock proteins (Hsps) protect protein substrates against conformational damage to promote the function of the proteins, prevent aggregation and prevent formation of toxic inclusion bodies. Protein aggregates and fibrils ... -
Heat, pH Induced Aggregation and Surface Hydrophobicity of S. cerevesiae Ssa1 Protein
Tutar, Yusuf; Arslan, Derya; Tutar, Lutfi (SPRINGER, 2010)Heat shock protein 70 is a conserved protein among organisms. Hsp70 helps substrate proteins to fold correctly. Unfolded substrate proteins increase the probability of the aggregate formation. High level recombinant protein ... -
Important Anti-Cancer Applications of Protein Based Nanoparticles
Ergul, Mustafa; Ergul, Merve; Tutar, Yusuf (BENTHAM SCIENCE PUBL LTD, 2013)Cancer is one of the most important health problems in the world and the treatment approaches are still challenging and generally not at desirable levels. Conventional anti-cancer agents may cause systemic toxicity, have ... -
Isolation and characterization of Heat Shock Protein 100-Batu1 from Toxoplasma gondii RH strain
Coskun, Kubra Acikalin; Tutar, Yusuf (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2015)Toxoplasma gondii is an intracellular parasitic protozoon which infects human and most warm-blooded animals. Almost one-third of the world's population is affected by life-threatening infection of T. gondii tachyzoites ...