Browsing by Author "Sarioglu, Y"
Now showing items 21-33 of 33
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Hydrogen-potassium ATPase inhibitors induce relaxation on rabbit prostatic strips in vitro
Bagcivan, I; Gokce, G; Ayan, S; Yildirim, S; Sarac, B; Kilicarslan, H; Sarioglu, Y (WILEY, 2002)Background: To determine the relaxant effect of omeprazole and lansaprazole, hydrogen-potassium (H+ -K+ ) ATPase inhibitors, on rabbit prostatic tissue in vitro . Methods: Male New Zealand white rabbits were sacrificed and ... -
Impaired contraction and relaxation in the aorta of streptozotocin-diabetic rats
Utkan, T; Sarioglu, Y; Yildirim, S (KARGER, 1998)It is known that diabetes mellitus alters the vascular responsiveness to several vasoconstrictors and vasodilators. Endothelium-derived nitric oxide is a potent endogenous nitrovasodilator, and endothelin-1 (ET-1) is a ... -
Inhibitor effect of omeprazole in isolated human myometrial smooth muscle
Yildirim, K; Sarioglu, Y; Kaya, T; Cetin, A; Yildirim, S (PERGAMON-ELSEVIER SCIENCE LTD, 2001)The aim of the present study was to investigate the effect of omeprazole, an H+-K+-ATPase inhibitor, in myometrial smooth muscle strips from women undergoing elective caesarean section at term. Isolated myometrial strips ... -
Inhibitory effects of isradipine on spontaneous and oxytocin- and carbachol-stimulated contractions of rat myometrium
Cetin, M; Kaya, T; Cetin, A; Sarioglu, Y (KARGER, 1998)Our aim was to investigate the effect of isradipine, a second-generation calcium channel blocker, on spontaneous and oxytocin- and carbachol-stimulated contractions of myometrium isolated from nonpregnant and pregnant rats. ... -
Investigation of the mechanism of nicotine induced relaxation in rabbit corpus cavernosum in vitro
Bagcivan, I; Gokce, G; Yildirim, S; Sarioglu, Y (SPRINGER, 2004)In order to determine whether nicotine acts on corporal smooth muscle, the mechanism of its effect on strips of rabbit corpus cavernosum was studied in vitro. Rabbit corpus cavernosum muscle strips were mounted in an organ ... -
Relaxant effect of omeprazole and lansoprazole in guinea pig gallbladder muscle strips in vitro
Aydin, C; Sarac, B; Koyuncu, A; Yildirim, S; Sen, M; Sarioglu, Y (SPRINGER JAPAN KK, 2003)Background. The aim of this study was to investigate the role of omeprazole and lansoprazole, H+-K+ ATPase inhibitors, in gallbladder smooth muscle contractility in vitro. Methods. Gallbladder muscle strips obtained from ... -
Relaxant effects of some benzothiazolinone derivatives on isolated rabbit corpus cavernosum
Yildirim, S; Simek, R; Ayan, S; Gokce, G; Sarioglu, Y; Safak, C (SPRINGER-VERLAG, 2001)In the present study, two 6-(fluorobenzoyl)-3-piperazinomethyl-2benzothiazoline ne derivatives were synthesized and their relaxant effects on isolated rabbit corpus cavernosum investigated. Compounds Y-16 and Y-21 can alter ... -
Relaxation effects of adrenomedullin in isolated rabbit corpus cavernosum smooth muscle
Gokce, G; Bagcivan, I; Kilicarslan, H; Yildirim, S; Gultekin, YE; Sarioglu, Y (BLACKWELL PUBLISHING LTD, 2004)To clarify the pharmacological effects of adrenomedullin, a potent vasodilator and hypotensive peptide isolated from human phaeochromocytoma cells, on corpus cavernosal smooth muscle in vitro, as the intracavernosal injection ... -
Relaxation induced by omeprazole does not change in diabetic rabbit corpus cavernosum
Ayan, S; Sarioglu, Y; Yildirim, S; Gokce, G; Bagcivan, I (WILEY, 2001)Objective To investigate the changes in relaxation responses to omeprazole in corpus cavernosal strips from rabbits with diabetes induced by alloxan. Materials and methods Diabetes was induced in 10 New Zealand white ... -
The role of K+ channels on the inhibitor effect of sevoflurane in pregnant rat myometrium
Kafali, H; Kaya, T; Gursoy, S; Bagcivan, I; Karadas, B; Sarioglu, Y (LIPPINCOTT WILLIAMS & WILKINS, 2002)Volatile anesthetics and K+ channel openers inhibit spontaneous contractions in myometrial smooth muscle. Volatile anesthetics modulate K+ channel activity We investigated the role of two K+ channel blockers on the effect ... -
Tolerance to isosorbide dinitrate in isolated strips of rabbit corpus cavernosum
Uma, S; Yildirim, S; Sarioglu, Y; Butuner, C; Yildirim, K (BLACKWELL SCIENCE LTD, 1998)The aim of this study was to investigate whether prolonged exposure to a high concentration of isosorbide dinitrate (ISDN) would result in tolerance being developed against its relaxant activity in strips of corpus cavernosum, ... -
Vascular smooth muscle reactivity and endothelium derived relaxing factor in experimental obstructive jaundice
Utkan, T; Sarioglu, Y; Utkan, NZ; Gonullu, NN; Yildirim, MK (SWETS ZEITLINGER PUBLISHERS, 1996)Obstructive jaundice is associated with a predisposition to systemic hypotension and acute renal failure. Altered vascular reactivity may contribute to the development of hypotension. In this experimental study on dogs, ... -
Vasorelaxing properties of some phenylacridine type potassium channel openers in isolated rabbit thoracic arteries
Berkan, O; Sarac, B; Simsek, R; Yildirim, S; Sarioglu, Y; Safak, C (EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2002)In this study, 1;2 new 2,2,7,7-tetramethyl-9-aryl-2,3,4,5,6,7,9,10-octahydro-1,8-acridindione derivatives were synthesised and. their effects on vascular potassium channels and mechanism of induced relaxations on ...