Browsing by Author "Tutar, Yusuf"
Now showing items 21-40 of 40
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Isolation and Identification of Free-Living Amoebae from Tap Water in Sivas, Turkey
Coskun, Kubra Acikalin; Ozcelik, Semra; Tutar, Lutfi; Elaldi, Nazif; Tutar, Yusuf (HINDAWI PUBLISHING CORPORATION, 2013)The present work focuses on a local survey of free-living amoebae (FLA) that cause opportunistic and nonopportunistic infections in humans. Determining the prevalence of FLA in water sources can shine a light on the need ... -
Key residues involved in Hsp70 regulatory activity and affect of co-chaperones on mechanism of action
Tutar, Yusuf (BENTHAM SCIENCE PUBL LTD, 2006)Hsp70 proteins assist refolding of polypeptides in an ATP dependent manner. Crystal structure of intact Hsp70 protein has not been determined yet however, structures of its two domains were solved separately. Allostery ... -
MicroRNAs and Cancer; an Overview
Tutar, Lutfi; Tutar, Esen; Tutar, Yusuf (BENTHAM SCIENCE PUBL LTD, 2014)MiRNAs are a family of small, endogenous, and evolutionarily conserved non-coding ribonucleic acids that have been involved in the regulation of several essential, cellular, and functional processes. MicroRNAs are known ... -
miRNA and Cancer; Computational and Experimental Approaches
Tutar, Yusuf (BENTHAM SCIENCE PUBL LTD, 2014)… -
Neglected role of cAMP receptor protein monomer
Tutar, Yusuf (SPRINGER, 2012)Lac operon transcription activation through CRP dimer depends on cAMP second messenger. The formation of CRP homodimers is mediated by protein-protein interactions between the monomers. Cyclic AMP ligand binding brings CRP ... -
A Novel Approach to Inhibit Heat Shock Response as Anticancer Strategy by Coumarine Compounds Containing Thiazole Skeleton
Koca, Irfan; Gumus, Mehmet; Ozgur, Aykut; Disli, Ali; Tutar, Yusuf (BENTHAM SCIENCE PUBL LTD, 2015)Inhibition of the Hsp90 function is an essential therapeutic approach and several inhibitors were designed as anti-cancer agents. These inhibitors are ATPases and they aim to deregulate Hsp90 folding function. ATPase ... -
Pseudogenes
Tutar, Yusuf (HINDAWI PUBLISHING CORPORATION, 2012)Pseudogenes are ubiquitous and abundant in genomes. Pseudogenes were once called "genomic fossils" and treated as "junk DNA" several years. Nevertheless, it has been recognized that some pseudogenes play essential roles ... -
Regulation of oncogenic genes by MicroRNAs and pseudogenes in human lung cancer
Tutar, Yusuf; Ozgur, Aykut; Tutar, Esen; Tutar, Lutfi; Pulliero, Alessandra; Izzotti, Alberto (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2016)Lung cancer is one of the most common mortal cancer types both for men and women. Several different biomarkers have been analyzed to reveal lung cancer prognosis pathways for developing efficient therapeutics and diagnostic ... -
Structure-Function Based Drug Design for Cancer Therapeutics
Tutar, Yusuf (BENTHAM SCIENCE PUBL LTD, 2016)… -
Syn, anti, and finally both conformations of cyclic AMP are involved in the CRP-dependent transcription initiation mechanism in E. coli lac operon
Tutar, Yusuf (JOHN WILEY & SONS LTD, 2008)The cyclic AMP receptor protein (CRP) of Escherichia coli regulates the activity of more than 150 genes. Allosteric changes in CRP structure accompanied by cAMP binding, initiate transcription through protein binding to ... -
Synthesis and anticancer activity of acyl thioureas bearing pyrazole moiety
Koca, Irfan; Ozgur, Aykut; Coskun, Kubra Acikalin; Tutar, Yusuf (PERGAMON-ELSEVIER SCIENCE LTD, 2013)In this work novel organic based compounds, acyl thiourea derivatives were synthesized and their anticancer activities were investigated. A new series of acyl thiourea derivatives containing pyrazole ring were prepared in ... -
Synthesis, molecular docking, and antitumoral activity of alnustone-like compounds against estrogen receptor alpha-positive human breast cancer
Kucukoglu, Kaan; Secinti, Hatice; Ozgur, Aykut; Secen, Hasan; Tutar, Yusuf (SCIENTIFIC TECHNICAL RESEARCH COUNCIL TURKEY-TUBITAK, 2015)Alnustone-like compounds are promising inhibitors for estrogen receptor alpha (ER-alpha), which is a novel cancer therapeutic target. Therefore, 10 alnustone-like compounds with substituents at the phenyl rings were ... -
Thematic Issue: Controlled Release and Drug Delivery in Diseases
Tutar, Yusuf (BENTHAM SCIENCE PUBL LTD, 2014)… -
Thematic Issue: Structural Characteristics of Short Peptides Solution Recombinant Therapeutic Protein Vaccines
Tutar, Yusuf (BENTHAM SCIENCE PUBL LTD, 2013)… -
Therapeutic Proteins: A to Z
Ozgur, Aykut; Tutar, Yusuf (BENTHAM SCIENCE PUBL LTD, 2013)In recent years, therapeutic proteins have become an important growing class of drugs in the pharmaceutics industry. The development of recombinant DNA technology has caused to appreciation of therapeutic value of many ... -
Therapeutic Targeting of microRNAs in Cancer: Future Perspectives
Tutar, Lutfi; Tutar, Esen; Ozgur, Aykut; Tutar, Yusuf (WILEY-BLACKWELL, 2015)The discovery of microRNAs (miRNAs) and their link with cancer has opened a new era in cancer therapeutics. Approximately, 18-24 nucleotides long, miRNAs can up-regulate or down-regulate gene expression in many cancer types ... -
Tumor Targeting of Polymeric Nanoparticles Conjugated with Peptides, Saccharides, and Small Molecules for Anticancer Drugs
Bayram, Banu; Ozgur, Aykut; Tutar, Lutfi; Tutar, Yusuf (BENTHAM SCIENCE PUBL LTD, 2017)Targeting drugs or pharmaceutical compounds to tumor site increases cancer treatment efficiency and therapeutic outcome. Nanoparticles are unique delivery systems for site-targeting within an organism. Many novel technologies ... -
Ydj1 but not Sis1 stabilizes Hsp70 protein under prolonged stress in vitro
Tutar, Lutfi; Tutar, Yusuf (JOHN WILEY & SONS INC, 2008)Yeast cytosol has two important co-chaperons; Ydj1 and Sis1. Genetic experiments showed that Ydj1 is not I essential for viability; however, cells lacking it grow very poorly at 30 degrees C or unable to grow at extreme ...