Browsing by Author "Ziad Joha"
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Anticancer activity of lycopene in HT‑29 colon cancer cell line
Dilara Ataseven; Ayşegül Öztürk; Mustafa Özkaraca; Ziad Joha (24. 03. 20)An inverse association between serum lycopene levels and the risk of cancers has been pointed out by many prospective and retrospective epidemiological studies which prompted more studies to be performed on animal models ... -
Investigation of the effect of sugammadex on glutamateinduced neurotoxicity in C6 cell line and the roles played by nitric oxide and oxidative stress pathways
Hasan Dirik; Ziad Joha (August 202)This experiment was intended to evaluate the effect of sugammadex on the cytotoxicity induced by glutamate, involving the nitric oxide and oxidative stress pathways. C6 glioma cells were used in the study. Glutamate ... -
Mechanism of anticancer effect of ETP‑45658, a PI3K/AKT/mTOR pathway inhibitor on HT‑29 Cells
Fatih Yulak; Ahmet Kemal Filiz; Ziad Joha; Mustafa Ergul (27. 10. 20)The PI3K pathway plays a crucial role in tumor cell proliferation across various cancers, including colon cancer, making it a promising treatment target. This study aims to investigate the antiproliferative activity of ... -
Mechanism of anticancer effect of gambogic acid on gastric signet ring cell carcinoma
Ziad Joha; Ayşegül Öztürk; Fatih Yulak; Özhan Karataş; Hilmi Ataseven (16. 08. 20)Gambogic acid has demonstrated inhibitory effects on the growth of various cancer cell types, such as breast cancer, pancreatic cancer, prostate cancer, lung cancer, and osteosarcoma. This study aims to investigate the ... -
The Role of Nitric Oxide Pathway in the Anti-Epileptogenic Effect of Valproic Acid in the Pentylenetetrazole-Kindling Model in Rats
Bilal Sahin; Ahmet Kemal Filiz; Ziad Joha (02. 06. 20)Though valproic acid (VPA) is used to treat seizures, more investigations have been needed to understand the effect of VPA on the nitric oxide pathway in epilepsy. Our investigation aimed to study the effect of VPA on ...