dc.contributor.author | Elagoz, S | |
dc.contributor.author | Egilmez, R | |
dc.contributor.author | Koyuncu, A | |
dc.contributor.author | Muslehiddinoglu, A | |
dc.contributor.author | Arici, S | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:21:57Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:21:57Z | |
dc.date.issued | 2006 | |
dc.identifier.issn | 1219-4956 | |
dc.identifier.issn | 1532-2807 | |
dc.identifier.uri | https://dx.doi.org/10.1007/BF02893427 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/10918 | |
dc.description | WOS: 000236866100003 | en_US |
dc.description | PubMed ID: 16554912 | en_US |
dc.description.abstract | It has previously been reported that intratumoral microvessel density (IMD), and the expression of bFGF and nm23-H1 are useful prognostic markers in colorectal cancer (CRC). In this study, a total of 100 CRCs were evaluated histopathologically, and IMD, bFGF and nm23-H1 expression were assessed by immunohistochemistry. IMD of patients increased with grade and stage, and this increase was statistically significant ( p< 0.05). A significantly higher incidence of high bFGF expression scores was also associated with increasing grade and stage ( p< 0.05). However, there was no significant difference between the grades in nm23-H1 expression ( p= 0.234). nm23-H1 expression occurred with lower incidence in stages C1, C2 and D than in stages B1 and B2 ( p< 0.05). Thus, a negative correlation was found between nm23-H1 expression and stage or lymph node metastasis (LNM) ( p< 0.05). IMD and bFGF expression were positively correlated with grade, stage, LNM, and lymphovascular invasion. Although positive correlation was found between IMD and bFGF, nm23-H1 expression negatively correlated with both of them. As a result, in clinical practice, increased IMD and bFGF expression and decreased nm23-H1 expression may provide valuable information in characterizing the malignant phenotype. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | SPRINGER | en_US |
dc.relation.isversionof | 10.1007/BF02893427 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | colorectal cancer | en_US |
dc.subject | microvascular density | en_US |
dc.subject | basic fibroblast growth factor | en_US |
dc.subject | nm23-H1 | en_US |
dc.title | The intratumoral microvessel density and expression of bFGF and nm23-H1 in colorectal cancer | en_US |
dc.type | article | en_US |
dc.relation.journal | PATHOLOGY & ONCOLOGY RESEARCH | en_US |
dc.contributor.department | Cumhuriyet Univ, Sch Med, Dept Pathol, TR-58140 Sivas, Turkey -- Cumhuriyet Univ, Sch Med, Dept Gen Surg, TR-58140 Sivas, Turkey | en_US |
dc.identifier.volume | 12 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.endpage | 27 | en_US |
dc.identifier.startpage | 21 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |