dc.contributor.author | Ozdemir, I | |
dc.contributor.author | Ustundag, N | |
dc.contributor.author | Guven, A | |
dc.contributor.author | Duran, B | |
dc.contributor.author | Demirci, F | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:22:20Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:22:20Z | |
dc.date.issued | 2005 | |
dc.identifier.issn | 0378-7346 | |
dc.identifier.uri | https://dx.doi.org/10.1159/000086962 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/11082 | |
dc.description | WOS: 000233038900001 | en_US |
dc.description | PubMed ID: 16020932 | en_US |
dc.description.abstract | Objective: To examine the effect of clomiphene citrate ( CC) on the ovarian, endometrial, and cervical histologies in a rat model. Methods: The rats (n = 40) were randomly assigned to 4 treatment groups: CC 50 ( repetitive doses of 0.2 mg CC); CC 100 ( repetitive doses of 0.4 mg CC); CC 200 ( repetitive doses of 0.8 mg CC), and control ( repetitive doses of normal saline). Each study group received its CC dose intraperitoneally in 2 ml saline for 5 days and the controls received 2 ml saline only. Each treatment cycle was repeated six times. Six months later the rats were euthanized. Their ovaries, uterine horns, and cervices were removed and examined for histologic changes. Results: We found no significant difference in the number of follicles and corpora lutea of the study groups ( p >0.05). The numbers of granulosa, theca, and luteal cells of the CC 100 and CC 200 groups were significantly higher than those of the CC 50 group and controls ( p < 0.05). There was no important finding related to pre-malign and malign changes in ovarian, endometrial and cervical samples of the control and CC 50 groups. Focal atypia and atypical mitoses were noted in 2 cases of granulosa cells in the CC 100 and CC 200 groups. Conclusion: We did not find an association between the use of CC and ovarian, endometrial, and cervical neoplasms; nevertheless, we noticed an increase in granulosa, theca and luteal cells with high doses of CC, which may be a risk factor for granulosa, theca, and luteal cell tumors. Copyright (C) 2005 S. Karger AG, Basel. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | KARGER | en_US |
dc.relation.isversionof | 10.1159/000086962 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | clomiphene citrate | en_US |
dc.subject | endometrial histology | en_US |
dc.subject | ovarian histology | en_US |
dc.subject | rat model | en_US |
dc.title | Effect of clomiphene citrate on ovarian, endometrial, and cervical histologies in a rat model | en_US |
dc.type | article | en_US |
dc.relation.journal | GYNECOLOGIC AND OBSTETRIC INVESTIGATION | en_US |
dc.contributor.department | Abant Izzet Baysal Univ, Duzce Sch Med, Dept Obstet & Gynecol, TR-81620 Konuralp, Duczce, Turkey -- Abant Izzet Baysal Univ, Duzce Sch Med, Dept Pathol, TR-81620 Konuralp, Duczce, Turkey -- Abant Izzet Baysal Univ, Duzce Sch Med, Dept Histol & Embryol, TR-81620 Konuralp, Duczce, Turkey -- Cumhuriyet Univ, Sch Med, Dept Obstet & Gynecol, Sivas, Turkey | en_US |
dc.identifier.volume | 60 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.endpage | 185 | en_US |
dc.identifier.startpage | 181 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |