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New benzimidazole‐oxadiazole derivatives: Synthesis, α‐glucosidase, α‐amylase activity, and molecular modeling studies as potential antidiabetic agents
(23.01.2023)
Benzimidazole‐1,3,4‐oxadiazole derivatives (5a–z) were synthesized and characterized
with different spectroscopic techniques such as
1
HNMR,
13
CNMR,andHRMS.The
synthesized analogs were examined against α‐glucosidase ...
Synthesis of Benzimidazole-1,2,4-triazole Derivatives as Potential Antifungal Agents Targeting 14α-Demethylase
(19.01.2023)
Invasive fungal infections (IFIs) are increasing as major infectious diseases
around the world, and the limited efficacy of existing medications has resulted in
substantial morbidity and death in patients due to the lack ...
New imidazole derivatives as aromatase inhibitor: Design, synthesis, biological activity, molecular docking, and computational ADME-Tox studies
(06.01.2023)
In this study, a series of imidazole derivatives was designed, synthesized, and evaluated for in vitro bi-
ological activity on the human breast cancer cell line MCF7 by MTT assay. To determine the selectivity
of the ...
INVESTIGATION OF THE ANTIPROLIFERATIVE EFFECT OF SALVIA CADMICA ON COLON CANCER
(07.05.2023)
Salvia cadmica is an endemic species known to have antioxidant, antimicrobial and aromatic
properties and the existence of Salvia species is known to date back to 753 BC. This species,
whose medicinal properties were ...
Design, synthesis and biological evaluation of novel ketone derivatives containing benzimidazole and 1,3,4-triazole as CA inhibitors
(03.10.2023)
In this study, we synthesized a series of new benzimidazole-triazole (6a-6k) derivatives and characterized them by 1 H NMR, 13C NMR, and HRMS. These compounds were evaluated for their inhibitory activity against hCA-I and ...
IMMUNOTHERAPY IN CANCER TREATMENT
(31.06.2023)
Cancer, which causes the death of approximately 10 million people
every year, is a type of disease that begins to spread to other parts of the body
by uncontrolled proliferation of cells in the tissues and organs of our ...
Use of newly synthetized magnetic Fe3O4 nanoparticles modified with hexadecyl trimethyl ammonium bromide for the sensitive analysis of antidepressant drugs, duloxetine and vilazodone in wastewater and urine samples
(RSC, 17th June )
A new enrichment and determination method involving HPLC-DAD analysis following magnetic solidphase
extraction (MSPE) was developed to detect trace amounts of two antidepressant drugs, namely,
duloxetine (DUL) and ...
Investigation of the effect of sugammadex on glutamateinduced neurotoxicity in C6 cell line and the roles played by nitric oxide and oxidative stress pathways
(August 202)
This experiment was intended to evaluate the effect of sugammadex on the
cytotoxicity induced by glutamate, involving the nitric oxide and oxidative
stress pathways. C6 glioma cells were used in the study. Glutamate ...
Assessing the Antiangiogenic Effects of Chalcones and Their Derivatives
(19 Jan 202)
Pathological angiogenesis plays a critical role in tumorigenesis and tumor pro gression, and anti-angiogenesis therapies have evinced promising antitumor
effects in solid tumors. Chalcone skeleton has been regarded as a ...
Mechanism of anticancer effect of gambogic acid on gastric signet ring cell carcinoma
(16. 08. 20)
Gambogic acid has demonstrated inhibitory effects on the growth of various cancer cell types, such as breast cancer, pancreatic
cancer, prostate cancer, lung cancer, and osteosarcoma. This study aims to investigate the ...